Role of GABRA2 in Moderating Subjective Responses to Alcohol

Alcoholism: Clinical and Experimental Research

Volumn 35, Issue 3, 2011, Pages 400-407

  Roh, Sungwon ^a   Matsushita, Sachio ^b   Hara, Sachiko ^a   Maesato, Hitoshi ^b   Matsui, Toshifumi ^c   Suzuki, Go ^b   Miyakawa, Tomohiro ^b   Ramchandani, Vijay A ^d   Li, Ting Kai ^d   Higuchi, Susumu ^b  

^a The Division of Clinical Research   (Japan)

^b Department of Psychiatry ^*  (Japan)

^c KURIHAMA NATIONAL HOSPITAL   (Japan)

^d NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

Alcohol; Alcohol Clamping; ALDH2; GABA; GABRA2; Subjective Response

Indexed keywords

ALCOHOL; ALDEHYDE DEHYDROGENASE ISOENZYME 2;

ADULT; ALCOHOL ABUSE; ALDH2 GENE; ALLELE; ARTICLE; BREATH ANALYSIS; FEMALE; GABRA2 GENE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOSITY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RECEPTOR GENE; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AFFECT; ALCOHOL DRINKING; ETHANOL; FEMALE; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, GABA-A; YOUNG ADULT;

EID: 79951930083     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2010.01357.x     Document Type: Article

References (54)

1. American Psychiatric Association (1994) Diagnositic and Statistical Manual of Mental Disorders, 4th ed. American Psychiatric Press, Washington, DC.
2. Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263-265.
3. Bauer LO, Covault J, Harel O, Das S, Gelernter J, Anton R, Kranzler HR (2007) Variation in GABRA2 predicts drinking behavior in project MATCH subjects. Alcohol Clin Exp Res 31:1780-1787.
4. Bauer LO, Hesselbrock VM (1993) EEG, autonomic and subjective correlates of the risk for alcoholism. J Stud Alcohol 54:577-589.
5. Chester JA, Cunningham CL (2002) GABA(A) receptor modulation of the rewarding and aversive effects of ethanol. Alcohol 26:131-143.
6. Cook TA, Luczak SE, Shea SH, Ehlers CL, Carr LG, Wall TL (2005) Associations of ALDH2 and ADH1B genotypes with response to alcohol in Asian Americans. J Stud Alcohol 66:196-204.
7. Covault J, Gelernter J, Hesselbrock V, Nellissery M, Kranzler HR (2004) Allelic and haplotypic association of GABRA2 with alcohol dependence. Am J Med Genet B Neuropsychiatr Genet 129:104-109.
8. Davies M (2003) The role of GABAA receptors in mediating the effects of alcohol in the central nervous system. J Psychiatry Neurosci 28:263-274.
9. Dick DM, Bierut L, Hinrichs A, Fox L, Bucholz KK, Kramer J, Kuperman S, Hesselbrock V, Schuckit M, Almasy L, Tischfield J, Porjesz B, Begleiter H, Nurnberger J Jr, Xuei X, Edenberg HJ, Foroud T (2006) The role of GABRA2 in risk for conduct disorder and alcohol and drug dependence across developmental stages. Behav Genet 36:577-590.
10. Edenberg HJ, Dick DM, Xuei X, Tian H, Almasy L, Bauer LO, Crowe RR, Goate A, Hesselbrock V, Jones K, Kwon J, Li TK, Nurnberger JI Jr, O'Connor SJ, Reich T, Rice J, Schuckit MA, Porjesz B, Foroud T, Begleiter H (2004) Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. Am J Hum Genet 74:705-714.
11. Eiler WJ 2nd, June HL (2007) Blockade of GABA(A) receptors within the extended amygdala attenuates D(2) regulation of alcohol-motivated behaviors in the ventral tegmental area of alcohol-preferring (P) rats. Neuropharmacology 52:1570-1579.
12. Fehr C, Sander T, Tadic A, Lenzen KP, Anghelescu I, Klawe C, Dahmen N, Schmidt LG, Szegedi A (2006) Confirmation of association of the GABRA2 gene with alcohol dependence by subtype-specific analysis. Psychiatr Genet 16:9-17.
13. Grobin AC, Matthews DB, Devaud LL, Morrow AL (1998) The role of GABA(A) receptors in the acute and chronic effects of ethanol. Psychopharmacology (Berl) 139:2-19.
14. Hanchar HJ, Dodson PD, Olsen RW, Otis TS, Wallner M (2005) Alcohol-induced motor impairment caused by increased extrasynaptic GABA(A) receptor activity. Nat Neurosci 8:339-345.
15. Harada S, Zhang S (1993) New strategy for detection of ALDH2 mutant. Alcohol Alcohol Suppl 1A:11-13.
16. Harvey SC, Foster KL, McKay PF, Carroll MR, Seyoum R, Woods JE 2nd, Grey C, Jones CM, McCane S, Cummings R, Mason D, Ma C, Cook JM, June HL (2002) The GABA(A) receptor alpha1 subtype in the ventral pallidum regulates alcohol-seeking behaviors. J Neurosci 22:3765-3775.
17. Heath AC, Martin NG (1992) Genetic differences in psychomotor performance decrement after alcohol: a multivariate analysis. J Stud Alcohol 53:262-271.
18. Higuchi S, Matsushita S, Kashima H (2006) New findings on the genetic influences on alcohol use and dependence. Curr Opin Psychiatry 19:253-265.
19. Hinckers AS, Laucht M, Schmidt MH, Mann KF, Schumann G, Schuckit MA, Heinz A (2006) Low level of response to alcohol as associated with serotonin transporter genotype and high alcohol intake in adolescents. Biol Psychiatry 60:282-287.
20. June HL, Foster KL, McKay PF, Seyoum R, Woods JE, Harvey SC, Eiler WJ, Grey C, Carroll MR, McCane S, Jones CM, Yin W, Mason D, Cummings R, Garcia M, Ma C, Sarma PV, Cook JM, Skolnick P (2003) The reinforcing properties of alcohol are mediated by GABA(A1) receptors in the ventral pallidum. Neuropsychopharmacology 28:2124-2137.
21. Kendler KS (2001) Twin studies of psychiatric illness: an update. Arch Gen Psychiatry 58:1005-1014.
22. Lappalainen J, Krupitsky E, Remizov M, Pchelina S, Taraskina A, Zvartau E, Somberg LK, Covault J, Kranzler HR, Krystal JH, Gelernter J (2005) Association between alcoholism and gamma-amino butyric acid alpha2 receptor subtype in a Russian population. Alcohol Clin Exp Res 29:493-498.
23. Lewontin RC (1988) On measures of gametic disequilibrium. Genetics 120:849-852.
24. Long JC, Knowler WC, Hanson RL, Robin RW, Urbanek M, Moore E, Bennett PH, Goldman D (1998) Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population. Am J Med Genet 81:216-221.
25. Low K, Crestani F, Keist R, Benke D, Brunig I, Benson JA, Fritschy JM, Rulicke T, Bluethmann H, Mohler H, Rudolph U (2000) Molecular and neuronal substrate for the selective attenuation of anxiety. Science 290:131-134.
26. Luczak SE, Elvine-Kreis B, Shea SH, Carr LG, Wall TL (2002) Genetic risk for alcoholism relates to level of response to alcohol in Asian-American men and women. J Stud Alcohol 63:74-82.
27. Maisto SA, Connors GJ, Tucker JA, McCollam JB, Adesso VJ (1980) Validation of the Sensation Scale, a measure of subjective physiological responses to alcohol. Behav Res Ther 18:37-43.
28. Martin CS, Earleywine M, Musty RE, Perrine MW, Swift RM (1993) Development and validation of the Biphasic Alcohol Effects Scale. Alcohol Clin Exp Res 17:140-146.
29. Martin NG, Oakeshott JG, Gibson JB, Starmer GA, Perl J, Wilks AV (1985) A twin study of psychomotor and physiological responses to an acute dose of alcohol. Behav Genet 15:305-347.
30. Matthews AG, Hoffman EK, Zezza N, Stiffler S, Hill SY (2007) The role of the GABRA2 polymorphism in multiplex alcohol dependence families with minimal comorbidity: within-family association and linkage analyses. J Stud Alcohol Drugs 68:625-633.
31. Morzorati SL, Ramchandani VA, Flury L, Li TK, O'Connor S (2002) Self-reported subjective perception of intoxication reflects family history of alcoholism when breath alcohol levels are constant. Alcohol Clin Exp Res 26:1299-1306.
32. Moss HB, Yao JK, Maddock JM (1989) Responses by sons of alcoholic fathers to alcoholic and placebo drinks: perceived mood, intoxication, and plasma prolactin. Alcohol Clin Exp Res 13:252-257.
33. Newlin DB, Thomson JB (1990) Alcohol challenge with sons of alcoholics: a critical review and analysis. Psychol Bull 108:383-402.
34. O'Connor S, Morzorati S, Christian J, Li TK (1998) Clamping breath alcohol concentration reduces experimental variance: application to the study of acute tolerance to alcohol and alcohol elimination rate. Alcohol Clin Exp Res 22:202-210.
35. O'Malley SS, Maisto SA (1985) Effects of family drinking history and expectancies on responses to alcohol in men. J Stud Alcohol 46:289-297.
36. Pierucci-Lagha A, Covault J, Feinn R, Nellissery M, Hernandez-Avila C, Oncken C, Morrow AL, Kranzler HR (2005) GABRA2 alleles moderate the subjective effects of alcohol, which are attenuated by finasteride. Neuropsychopharmacology 30:1193-1203.
37. Pollock VE (1992) Meta-analysis of subjective sensitivity to alcohol in sons of alcoholics. Am J Psychiatry 149:1534-1538.
38. Ramchandani VA, Bolane J, Li TK, O'Connor S (1999a) A physiologically-based pharmacokinetic (PBPK) model for alcohol facilitates rapid BrAC clamping. Alcohol Clin Exp Res 23:617-623.
39. Ramchandani VA, O'Connor S, Blekher T, Kareken D, Morzorati S, Nurnberger J Jr, Li TK (1999b) A preliminary study of acute responses to clamped alcohol concentration and family history of alcoholism. Alcohol Clin Exp Res 23:1320-1330.
40. Reich T, Edenberg HJ, Goate A, Williams JT, Rice JP, Van Eerdewegh P, Foroud T, Hesselbrock V, Schuckit MA, Bucholz K, Porjesz B, Li TK, Conneally PM, Nurnberger JI Jr, Tischfield JA, Crowe RR, Cloninger CR, Wu W, Shears S, Carr K, Crose C, Willig C, Begleiter H (1998) Genome-wide search for genes affecting the risk for alcohol dependence. Am J Med Genet 81:207-215.
41. Roh S, Matsushita S, Higuchi S (2008) Genetic influences on alcohol use and dependence, in Research on the Neurobiology of Alcohol Use Disorders (Sher L ed), pp. 291-320. Nova Science Publishers, New York.
42. Rudolph U, Crestani F, Benke D, Brunig I, Benson JA, Fritschy JM, Martin JR, Bluethmann H, Mohler H (1999) Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes. Nature 401:796-800.
43. Savoie TM, Emory EK, Moody-Thomas S (1988) Acute alcohol intoxication in socially drinking female and male offspring of alcoholic fathers. J Stud Alcohol 49:430-435.
44. Schuckit MA (1984) Subjective responses to alcohol in sons of alcoholics and control subjects. Arch Gen Psychiatry 41:879-884.
45. Schuckit MA (1994) Low level of response to alcohol as a predictor of future alcoholism. Am J Psychiatry 151:184-189.
46. Schuckit MA, Smith TL (1996) An 8-year follow-up of 450 sons of alcoholic and control subjects. Arch Gen Psychiatry 53:202-210.
47. Schuckit MA, Smith TL, Anderson KG, Brown SA (2004) Testing the level of response to alcohol: social information processing model of alcoholism risk - a 20-year prospective study. Alcohol Clin Exp Res 28:1881-1889.
48. Schuckit MA, Smith TL, Danko GP, Pierson J, Hesselbrock V, Bucholz KK, Kramer J, Kuperman S, Dietiker C, Brandon R, Chan G (2007) The ability of the Self-Rating of the Effects of Alcohol (SRE) Scale to predict alcohol-related outcomes five years later. J Stud Alcohol Drugs 68:371-378.
49. Schuckit MA, Smith TL, Kalmijn J, Tsuang J, Hesselbrock V, Bucholz K (2000) Response to alcohol in daughters of alcoholics: a pilot study and a comparison with sons of alcoholics. Alcohol Alcohol 35:242-248.
50. Schuckit MA, Tsuang JW, Anthenelli RM, Tipp JE, Nurnberger JI Jr (1996) Alcohol challenges in young men from alcoholic pedigrees and control families: a report from the COGA project. J Stud Alcohol 57:368-377.
51. Soyka M, Preuss UW, Hesselbrock V, Zill P, Koller G, Bondy B (2008) GABA-A2 receptor subunit gene (GABRA2) polymorphisms and risk for alcohol dependence. J Psychiatr Res 42:184-191.
52. Tauber M, Calame-Droz E, Prut L, Rudolph U, Crestani F (2003) alpha2-gamma-Aminobutyric acid (GABA)A receptors are the molecular substrates mediating precipitation of narcosis but not of sedation by the combined use of diazepam and alcohol in vivo. Eur J Neurosci 18:2599-2604.
53. Viken RJ, Rose RJ, Morzorati SL, Christian JC, Li TK (2003) Subjective intoxication in response to alcohol challenge: heritability and covariation with personality, breath alcohol level, and drinking history. Alcohol Clin Exp Res 27:795-803.
54. Wall TL, Johnson ML, Horn SM, Carr LG, Smith TL, Schuckit MA (1999) Evaluation of the self-rating of the effects of alcohol form in Asian Americans with aldehyde dehydrogenase polymorphisms. J Stud Alcohol 60:784-789.