Inhibition of estrogen signaling through depletion of estrogen receptor alpha by ursolic acid and betulinic acid from Prunella vulgaris var. lilacina

Biochemical and Biophysical Research Communications

Volumn 451, Issue 2, 2014, Pages 282-287

  Kim, Hye In ^a   Quan, Fu Shi ^b   Kim, Ji Eun ^a   Lee, Na Rae ^a   Kim, Hyun Ji ^a   Jo, Su Ji ^a   Lee, Chae Min ^a   Jang, Dae Sik ^a   Inn, Kyung Soo ^a  

^a Kyung Hee University   (South Korea)

^b Kyung Hee University Hospital   (South Korea)

Author keywords

Antiestrogenic effect; Betulinic acid; Estrogen; Estrogen receptor; Prunella vulgaris var. lilacina; Ursolic acid

Indexed keywords

BETULIC ACID; CAFFEIC ACID; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; GROWTH REGULATION BY ESTROGEN IN BREAST CANCER 1; HYPERIN; LUCIFERASE; MEMBRANE PROTEIN; MESSENGER RNA; OLEANOLIC ACID; PROSTATE SPECIFIC ANTIGEN; PRUNELLA VULGARIS EXTRACT; ROSMARINIC ACID; RUTOSIDE; UNCLASSIFIED DRUG; URSOLIC ACID;

ANTIESTROGENIC EFFECT; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY ASSAY; DRUG ACTIVITY; DRUG INHIBITION; DRUG ISOLATION; ESTROGEN RESPONSIVE ELEMENT; FLOWER STALK; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PRUNELLA; PRUNELLA VULGARIS VAR. LILACINA; SIGNAL TRANSDUCTION;

LAMIACEAE; PRUNELLA VULGARIS;

ANTIESTROGENIC EFFECT; BETULINIC ACID; ESTROGEN; ESTROGEN RECEPTOR; PRUNELLA VULGARIS VAR. LILACINA; URSOLIC ACID;

BREAST NEOPLASMS; CELL LINE, TUMOR; DRUG EVALUATION, PRECLINICAL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR MODULATORS; ESTROGENS; FEMALE; HUMANS; MALE; MCF-7 CELLS; NEOPLASM PROTEINS; PHYTOTHERAPY; PLANTS, MEDICINAL; PROMOTER REGIONS, GENETIC; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; PRUNELLA; RNA, MESSENGER; RNA, NEOPLASM; SIGNAL TRANSDUCTION; TRITERPENES;

EID: 84906939677     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.07.115     Document Type: Article

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