Intervertebral disc and stem cells cocultured in biomimetic extracellular matrix stimulated by cyclic compression in perfusion bioreactor

Spine Journal

Volumn 14, Issue 9, 2014, Pages 2127-2140

  Tsai, Tsung Lin ^a,b   Nelson, Brenton C ^a,b   Anderson, Paul A ^a   Zdeblick, Thomas A ^a   Li, Wan Ju ^a,b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b Wisconsin Electric Machines and Power Electronics Consortium   (United States)

Author keywords

Biomimetic scaffold; Bioreactor; Electrospinning; Intervertebral disc; Mesenchymal stem cell; Tissue engineering

Indexed keywords

5' NUCLEOTIDASE; AGGRECAN; ALCIAN BLUE; ALKALINE PHOSPHATASE; COLLAGEN TYPE 1; COLLAGEN TYPE 2; ENDOGLIN; HTRA1 PROTEIN; MEMBRANE ANTIGEN; MOLECULAR SCAFFOLD; OCTAMER TRANSCRIPTION FACTOR 4; ORGANIC CATION TRANSPORTER 3; PROTEIN; THY 1 ANTIGEN; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX9; UNCLASSIFIED DRUG; HYDROGEL;

ADULT; ANNULUS FIBROSUS; ARTICLE; BIOMIMETICS; BIOREACTOR; CARTILAGE CELL; CELL DIFFERENTIATION; CELL LINEAGE; CELL STRUCTURE; CHONDROGENESIS; CLINICAL ARTICLE; COCULTURE; COMPRESSION; CONTROLLED STUDY; CYCLIC COMPRESSION; DOWN REGULATION; ELECTROSPINNING; EXTRACELLULAR MATRIX; GENE EXPRESSION; HUMAN; HUMAN ANNULUS FIBROSUS CELL; HUMAN CELL; HUMAN NUCLEUS PULPOSUS CELL; HUMAN TISSUE; HYDROGEL; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DEGENERATION; MECHANICAL STIMULATION; MESENCHYMAL STEM CELL; NERVE ENDING; NUCLEUS PULPOSUS; OSTEOBLAST; PERFUSION BIOREACTOR; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCANNING ELECTRON MICROSCOPY; TISSUE ENGINEERING; UPREGULATION; VERTEBRA BODY; CARTILAGE; CULTURE TECHNIQUE; CYTOLOGY; INTERVERTEBRAL DISC DEGENERATION; MECHANICAL STRESS; MESENCHYMAL STROMA CELL; PHYSIOLOGY; PROCEDURES;

BIOMIMETICS; BIOREACTORS; CARTILAGE; CELL DIFFERENTIATION; CHONDROGENESIS; COCULTURE TECHNIQUES; CULTURE TECHNIQUES; EXTRACELLULAR MATRIX; HUMANS; HYDROGELS; INTERVERTEBRAL DISC; INTERVERTEBRAL DISC DEGENERATION; MESENCHYMAL STROMAL CELLS; STRESS, MECHANICAL; TISSUE ENGINEERING;

EID: 84906939572     PISSN: 15299430     EISSN: 18781632     Source Type: Journal    
DOI: 10.1016/j.spinee.2013.11.062     Document Type: Article

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