A stimulation unit for the application of mechanical strain on tissue engineered anulus fibrosus cells: A new system to induce extracellular matrix synthesis by anulus fibrosus cells dependent on cyclic mechanical strain

International Journal of Artificial Organs

Volumn 28, Issue 12, 2005, Pages 1242-1250

  Gokorsch, S ^a   Weber, C ^a   Wedler, T ^a   Czermak, Peter ^a,b  

^a TECHNISCHE HOCHSCHULE MITTELHESSEN   (Germany)

^b Sunflower Networking Group   (United States)

Author keywords

Bioreactor system; Extracellular matrix; Intervertebral disc; Mechanical pressure

Indexed keywords

BIOCONVERSION; CELLS; COMPUTER SOFTWARE REUSABILITY; CYTOLOGY; HYDROXYPROLINE; TISSUE;

ANULUS FIBROSUS; BIOREACTOR SYSTEM; CELL MATRIX; CULTURE PLATES; CYCLIC MECHANICAL STRAINS; EXTRACELLULAR MATRICES; EXTRACELLULAR MATRIX SYNTHESIS; INTERVERTEBRAL DISK; MECHANICAL PRESSURE; STIMULATION UNITS;

BIOREACTORS;

AGAROSE; GLYCOSAMINOGLYCAN; HYDROXYPROLINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BATCH PROCESS; BIOREACTOR; CELL STIMULATION; CONTAMINATION; CONTINUOUS CULTURE; CONTROLLED STUDY; CULTURE VESSEL; EXTRACELLULAR MATRIX; HEART MUSCLE CELL; IMMOBILIZED CELL; INSTRUMENT STERILIZATION; INTERVERTEBRAL DISK; MECHANICAL STRESS; NONHUMAN; PLATING MEDIUM; SAMPLING; TISSUE CULTURE; TISSUE ENGINEERING; VASCULAR RING;

EID: 31644451404     PISSN: 03913988     EISSN: None     Source Type: Journal    
DOI: 10.1177/039139880502801208     Document Type: Article

References (45)

1. Anderson GB. Epidemiology of low back pain. Acta Orthop Scand 1998; 281 (suppl): S28-31.
2. Baldwin NG. Lumbar disc disease: The natural history. Neurosurg Focus 2002; 13: E2.
3. Adams MA. Biomechanics of backpain. Acupunct Med 2004; 22: 178-88.
4. Holm S, Maroudas A, Urban JP, Selstam G, Nachemson A. Nutrition of the intervertebral disc: Solute transport and metabolism. Connect Tissue Res 1981; 8: 101-19.
5. Maroudas A, Weinberg PD, Parker KH, Winlove CP. The distributions and diffusivities of small ions in chondroitin sulphate, hyaluronate, and some proteoglycan solutions. Biophys Chem 1988; 32: 257-70.
6. Ogata K, Whiteside LA. 1980 Volvo award winner in basic science. Nutritional pathways of the intervertebral disc. An experimental study using hydrogen washout technique. Spine 1981; 6: 211-6.
7. Ohshima H, Urban JP. The effect of lactate and pH on proteoglycan and protein synthesis rates in the intervertebral disc. Spine 1992; 17: 1079-82.
8. Darling EM, Athanasiou KA. Articular cartilage bioreactors and bioprocesses. Tissue Eng 2003; 9: 9-26.
9. Smith RL, Carter DR, Schurman DJ, Smith RL. Pressure and shear differentially alter human articular chondrocyte metabolism: A review. Clin Orthop 2004; 427 (suppl): S89-95.
10. Lai WM, Sun DD, Ateshian GA, Guo XE, Mow VC. Electrical signals for chondrocytes in cartilage. Biorheology 2002; 39: 39-45.
11. Sato K, Kikuchi S, Yonezawa T. In vivo intradiscal pressure measurement in healthy individuals and in patients with ongoing back problems. Spine 1999; 24: 2468-74.
12. Bibby SR, Fairbank JC, Urban MR, Urban JP. Cell viability in scoliotic discs in relation to disc deformity and nutrient levels. Spine 2002; 27: 2220-8.
13. Gruber HE, Hanley EN Jr. Recent advances in disc cell biology. Spine 2003; 28: 186-93.
14. Gruber, HE, Stasky AA, Hanley EN Jr. Characterization and phenotypic stability of human disc cells in vitro. Matrix Biol 1997; 16: 285-8.
15. Pei M, Solchaga LA, Seidel J, Zeng L, Vunjak-Novakovic G, Caplan AI, Freed LE. Bioreactors mediate the effectiveness of tissue engineering scaffolds. FASEB J 2002; 16: 1691-4.
16. Gokorsch S, Nehring D, Grottke, Czermak P. Hydrodynamic stimulation and long term cultivation of nucleus pulposus cells. A new bioreactor system to induce extracellular matrixsynthesis by nucleus pulposus cell dependent on intermittent hydrostatic pressure. Int J Artif Organs 2004; 27: 962-70.
17. Kasra M, Goel V, Martin J, Wang ST, Choi W, Buckwalter J. Effect of dynamic hydrostatic pressure on rabbit intervertebral disc cells. J Orthop Res 2003; 21: 597-603.
18. Ishihara H, McNally DS, Urban JP, Hall AC. Effects of hydrostatic pressure on matrix synthesis in different regions of the intervertebral disk. J Appl Physiol 1996; 80: 839-46.
19. Carver SE, Heath CA. Semi-continuous perfusion system for delivering intermittent physiological pressure to regenerating cartilage. Tissue Eng 1999; 5: 1-11.
20. Altman GH, Horan RL, Martin I, et al. Cell differentiation by mechanical stress. FASEB J 2002; 16: 270-2.
21. Marlovits S, Tichy B, Truppe M, Gruber D, Schlegel W. Collagen expression in tissue engineered cartilage of aged human articular chondrocytes in a rotating bioreactor. Int J Artif Organs 2003; 26: 319-30.
22. Raimondi MT, Boschetti F, Falcone L, et al. Mechanobiology of engineered cartilage cultured under a quantified fluid-dynamic environment. Biomech Model Mechanobiol 2002; 1: 69-82.
23. Frank EH, Jin M, Loening AM, Levenston ME, Grodzinsky AJ. A versatile shear and compression apparatus for mechanical stimulation of tissue culture explants. J Biomech 2000; 33: 1523-7.
24. Matsumoto T, Kawakami M, Kuribayashi K, Takenaka T, Tamaki T. Cyclic mechanical stretch stress increases the growth rate and collagen synthesis of nucleus pulposus cells in vitro. Spine 1999, 24: 315-9.
25. Parkkinen J, Lammi MJ, Helminen HJ, Tammi M. Local stimulation of PG synthesis in articular cartilage explants by dynamic compression in vitro. J Orthop Res 1992; 10: 610-20.
26. Bonassar LJ, Grodzinsky AJ, Frank EH, Davila SG, Bhaktav NR, Trippel SB. The effect of dynamic compression on the response of articular cartilage to insulin-like growth factor-I. J Orthop Res 2001; 19: 11-7.
27. Buschmann MD, Gluzband YA, Grodzinsky AJ, Hunziker EB. Mechanical compression modulates matrix biosynthesis in chondrocyte/agarose culture. J Cell Sci 1995; 108: 1497-508.
28. Mauck RL, Soltz MA, Wang CC, et al. Functional tissue engineering of articular cartilage through dynamic loading of chondrocyte-seeded agarose gels. J Biomech Eng 2000; 122: 252-60.
29. Demarteau O, Jakob M, Schäfer D, Heberer M, Martin I. Development and validation of a bioreactor for physical stimulation of engineered cartilage. Biorheology 2003; 40: 331-6.
30. Hutton WC, Toribatake Y, Elmer WA, Ganey TM, Tomita K, Whitesides TE. The effect of compressive force applied to the intervertebral disc in vivo. A study of proteoglycans and collagen. Spine 1998; 23: 2524-37.
31. MacLean JJ, Lee CR, Grad S, Ito K, Alini M, Iatridis JC. Effects of immobilization and dynamic compression on intervertebral disc cell gene expression in vivo. Spine 2003; 28: 973-81.
32. Iatridis JC, Mente PL, Stokes IA, Aronsson DD, Alini M. Compression-induced changes in intervertebral disc properties in a rat tail model. Spine 1999; 24: 996-1002.
33. Maclean JJ, Lee CR, Alini M, Iatridis JC. Anabolic and catabolic mRNA levels of the intervertebral disc vary with the magnitude and frequency of in vivo dynamic compression. J Orthop Res 2004; 22: 1193-200.
34. Ishihara H, Urban JP. Effects of low oxygen concentrations and metabolic inhibitors on proteoglycan and protein synthesis rates in the intervertebral disc. J Orthop Res 1999; 17: 829-35.
35. Bartels EM, Fairbank JC, Winlove CP, Urban JP. Oxygen and lactate concentrations measured in vivo in the intervertebral discs of patients with scoliosis and back pain. Spine 1998; 23: 1-7.
36. Gruber HE, Fisher EC Jr, Desai B, Stasky AA, Hoelscher G, Hanley EN Jr. Human intervertebral disc cells from the annulus: three-dimensional culture in agarose or alginate and responsiveness to TGF-beta1. Exp Cell Res 1997; 235: 13-21.
37. Eijkelkamp MF, van Donkelaar CC, Veldhuizen AG, van Horn J, Huyghe JM, Verkerke GJ. Requirements for an artificial intervertebral disc. Int J Artif Organs 2001; 24: 311-21.
38. Eijkelkamp MF, Hayen J, Veldhuizen AG, van Horn JR, Verkerke GJ. Improving the fixation of an artificial intervertebral disc. Int J Artif Organs 2002; 25: 327-33.
39. Mattioli-Belmonte M, Giavaresi G, Biagini G, et al. Tailoring biomaterial compatibility: In vivo tissue response in vitro cell behavior. Int J Artif Organs 2003; 26: 1077-85.
40. Lodish HA, Zipursky SL, Matsudaira P, Baltimore D, Darnell JE. Molecular cell biology: Integrating cells into tissues. New York: W.H. Freeman & Co.; 2000.
41. Reddy GK, Enwemeka CS. A simplified method for the analysis of hydroxyproline in biological tissues. Clin Biochem 1996; 29: 225-9.
42. Farndale RW, Buttle DJ, Barrett AJ. Improved discrimination of sulfated glycosaminoglycans by use of dimethylmethylenblue. Biochem Biophys Acta 1986; 883: 173-7.
43. Kim YJ, Sah RL, Doong JY, Grodzinsky AJ. Fluorometric assay of DNA in cartilage explants using Hoechst 33258. Anal Biochem 1988; 174: 168-76.
44. Davisson T, Kunig S, Chen A, Sah R, Ratcliffe A. Static and dynamic compression modulate matrix metabolism in tissue engineered cartilage. J Orthop Res 2002; 20: 842-8.
45. Czermak P, Nehring D, Weber C, Gokorsch S. Inventive bioreactors and bioreactor systems. Patent WO 2005/087912 AZ.