Ricinine: A pyridone alkaloid from Ricinus communis that activates the Wnt signaling pathway through casein kinase 1α

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 17, 2014, Pages 4597-4601

  Ohishi, Kensuke ^a   Toume, Kazufumi ^a   Arai, Midori A ^a   Sadhu, Samir K ^b   Ahmed, Firoj ^c   Mizoguchi, Takamasa ^a   Itoh, Motoyuki ^a   Ishibashi, Masami ^a  

^a CHIBA UNIVERSITY   (Japan)

^b KHULNA UNIVERSITY   (Bangladesh)

^c UNIVERSITY OF DHAKA   (Bangladesh)

Author keywords

Alkaloid; Euphorbiaceae; Ricinus communis; Wnt signal; Zebrafish

Indexed keywords

7 OXO BETA SITOSTEROL; ALKALOID; BETA CATENIN; BETA SITOSTEROL 3 O DEXTRO GLUCOPYRANOSIDE; CASEIN KINASE IALPHA; GLYCOGEN SYNTHASE KINASE 3BETA; LUPEOL; METHANOL; PYRIDONE DERIVATIVE; PYRVINIUM EMBONATE; RICININE; RICINUS COMMUNIS EXTRACT; T CELL FACTOR PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN; PROTEIN KINASE INHIBITOR;

ANIMAL TISSUE; ARTICLE; CELL ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG MECHANISM; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITION; FRACTIONATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PLANT STEM; PROTEIN ANALYSIS; SIGNAL TRANSDUCTION; ZEBRA FISH; ANIMAL; CELL CULTURE; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; EMBRYOLOGY; HEK293 CELL LINE; ISOLATION AND PURIFICATION; METABOLISM; RICINUS COMMUNIS; STRUCTURE ACTIVITY RELATION; WNT SIGNALING PATHWAY;

DANIO RERIO; EUPHORBIACEAE; RICINUS COMMUNIS;

ALKALOIDS; ANIMALS; CASEIN KINASE IALPHA; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; HEK293 CELLS; HUMANS; MOLECULAR STRUCTURE; PLANT STEMS; PROTEIN KINASE INHIBITORS; PYRIDONES; RICINUS; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; WNT PROTEINS; WNT SIGNALING PATHWAY; ZEBRAFISH;

EID: 84906938582     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.07.027     Document Type: Article

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