An increased burden of common and rare lipid-associated risk alleles contributes to the phenotypic spectrum of hypertriglyceridemia

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 31, Issue 8, 2011, Pages 1916-1926

  Johansen, Christopher T ^a,b   Wang, Jian ^a   Lanktree, Matthew B ^a   McIntyre, Adam D ^a   Ban, Matthew R ^a   Martins, Rebecca A ^a   Kennedy, Brooke A ^a   Hassell, Reina G ^a   Visser, Maartje E ^c,d   Schwartz, Stephen M ^e   Voight, Benjamin F ^f,h   Elosua, Roberto ⁱ   Salomaa, Veikko ^j   O'Donnell, Christopher J ^g,k,l   Dallinga Thie, Geesje M ^c,d   Anand, Sonia S ^m   Yusuf, Salim ^m   Huff, Murray W ^a,b   Kathiresan, Sekar ^f,h   Cao, Henian ^a   Hegele, Robert A ^a,b   more..

^a ROBARTS RESEARCH INSTITUTE   (Canada)

^b WESTERN UNIVERSITY   (Canada)

^c Departments of Experimental Vascular Medicine   (Canada)

^d ACADEMIC MEDICAL CENTER   (Netherlands)

^e UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^f Center for Human Genetic Research   (United States)

^g MASSACHUSETTS GENERAL HOSPITAL   (United States)

^h BROAD INSTITUTE OF MIT AND HARVARD   (United States)

ⁱ INST MUNIC D INVESTIGACIO MEDICA   (Spain)

^j NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^k HARVARD MEDICAL SCHOOL   (United States)

^l FRAMINGHAM HEART STUDY   (United States)

^m MCMASTER UNIVERSITY   (Canada)

more..

Author keywords

genetic risk scores; genetic variation; hypertriglyceridemia; lipoprotein; pleiotropy

Indexed keywords

APOLIPOPROTEIN E2; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE PHENOTYPE CORRELATION; HUMAN; HYPERLIPOPROTEINEMIA; HYPERLIPOPROTEINEMIA TYPE 2; HYPERLIPOPROTEINEMIA TYPE 2B; HYPERLIPOPROTEINEMIA TYPE 3; HYPERLIPOPROTEINEMIA TYPE 4; HYPERLIPOPROTEINEMIA TYPE 5; HYPERTRIGLYCERIDEMIA; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PLEIOTROPY; PRIORITY JOURNAL;

ADULT; AGED; ALLELES; APOLIPOPROTEIN E2; CASE-CONTROL STUDIES; CHOLESTEROL, HDL; CHOLESTEROL, LDL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HUMANS; HYPERLIPOPROTEINEMIA TYPE IV; HYPERTRIGLYCERIDEMIA; LIPIDS; MALE; MIDDLE AGED; MULTIFACTORIAL INHERITANCE; PHENOTYPE; RISK FACTORS; TRIGLYCERIDES;

EID: 80051551063     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.111.226365     Document Type: Article

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