7,8-Dihydroxyflavone protects PC12 cells against 6-hydroxydopamine-induced cell death through modulating PI3K/Akt and JNK pathways

Neuroscience Letters

Volumn 581, Issue , 2014, Pages 85-88

  Han, Xiao Hua ^a   Cheng, Meng Nan ^a   Chen, Lei ^a   Fang, Hui ^a   Wang, Li Juan ^a   Li, Xue Ting ^a   Qu, Zhi Qiang ^b  

^a QINGDAO UNIVERSITY MEDICAL COLLEGE   (China)

^b QINGDAO UNIVERSITY   (China)

Author keywords

6 Hydroxydopamine; 7,8 Dihydroxyflavone; Akt; JNK; PC12 cells

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 7,8 DIHYDROXYFLAVONE; CYTOTOXIC AGENT; OXIDOPAMINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; 2-(2-AMINO-3-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; 6,7-DIHYDROXYFLAVONE; CHROMONE DERIVATIVE; FLAVONE DERIVATIVE; FLAVONOID; MORPHOLINE DERIVATIVE; NEUROPROTECTIVE AGENT;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL DEATH; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVATION; IN VITRO STUDY; INTRACELLULAR SIGNALING; NEUROPROTECTION; NONHUMAN; PC12 CELL LINE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; WESTERN BLOTTING; APOPTOSIS; ENZYME INHIBITION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; METABOLISM; PHOSPHORYLATION;

ANIMALS; APOPTOSIS; CELL SURVIVAL; CHROMONES; FLAVONES; FLAVONOIDS; MAP KINASE SIGNALING SYSTEM; MORPHOLINES; NEUROPROTECTIVE AGENTS; OXIDOPAMINE; PC12 CELLS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS;

EID: 84906891385     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2014.08.016     Document Type: Article

References (22)

1. Beal M.F. Experimental models of Parkinson's disease. Nat. Rev. Neurosci. 2001, 2:325-334.
2. Chen J., Chua K.W., Chua C.C., Yu H., Pei A., Chua B.H., Hamdy R.C., Liu X. Antioxidant activity of 7,8-dihydroxyflavone provides neuroprotection against glutamate-induced toxicity. Neurosci. Lett. 2011, 499:181-185.
3. Chong Z.Z., Li F., Maiese K. Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative disease. Prog. Neurobiol. 2005, 75:207-246.
4. Devi L., Ohno M. 7,8-Dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease. Neuropsychopharmacology 2012, 37:434-444.
5. Gary D.S., Mattson M.P. Integrin signalling via the PI3-kinase-Akt pathway increases neuronal resistance to glutamateinduced apoptosis. J. Neurochem. 2001, 76:1485-1496.
6. Gupta V.K., You Y., Li J.C., Klistorner A., Graham S.L. Protective effects of 7,8-dihydroxyflavone on retinal ganglion and RGC-5 cells against excitotoxic and oxidative stress. J. Mol. Neurosci. 2013, 49:96-104.
7. Han X., Zhu S., Wang B., Chen L., Li R., Yao W., Qu Z. Antioxidant action of 7,8-dihydroxyflavone protects PC12 cells against 6-hydroxydopamine-induced cytotoxicity. Neurochem. Int. 2014, 64:18-23.
8. Jang W., Liu X., Yepes M., Shepherd K.R., Miller G.W., Liu Y., Wilson W.D., Xiao G., Blanchi B., Sun Y.E., Ye K. A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:2687-2692.
9. Kim M.K., Kim S.C., Kang J.I., Hyun J.H., Boo H.J., Eun S.Y., Park D.B., Yoo E.S., Kang H.K., Kang J.H. 6-Hydroxydopamine-induced PC12 cell death is mediated by MEF2D down-regulation. Neurochem. Res. 2011, 36:223-231.
10. Levites Y., Amit T., Youdim M.B.H., Mandel S. Involvement of protein kinase C activation and cell survival/cell cycle genes in green tea polyphenol-epigallocatechin 3-gallate neuroprotective action. J. Biol. Chem. 2002, 34:30574-30580.
11. Noshita N., Lewen A., Sugawara T., Chan P.H. Evidence of phosphorylation of Akt and neuronal survival after transient focal cerebral ischemia in mice. J. Cereb. Blood Flow Metab. 2001, 21:1442-1450.
12. Pantano C., Shrivastava P., McElhinney B., Janssen-Heininger Y.M. Hydrogen peroxide signalling through tumor necrosis factor receptor 1 leads to selective activation of c-Jun N-terminal kinase. J. Biol. Chem. 2003, 278:44091-44440.
13. Rodriguez-Blanco J., Martín V., Herrera F., García-Santos G., Antolín I., Rodriguez C. Intracellular signaling pathways involved in post-mitotic dopaminergic PC12 cell death induced by 6-hydroxydopamine. J. Neurochem. 2008, 107:127-140.
14. Soto-Otero R., Méndez-Alvarez E., Hermida-Ameijeiras A., Muñoz-Patiño A.M., Labandeira-Garcia J.L. Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease. J. Neurochem. 2000, 74:1605-1612.
15. Stanciu M., Wang Y., Kentor R., Burke N., Watkins S., Kress G., Reynolds I., Klann E., Angiolieri M.R., Johnson J.W., DeFranco D.B. Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures. J. Biol. Chem. 2000, 275:12200-12206.
16. Subramaniam S., Zirrgiebel U., von Bohlen Und Halbach O., Strelau J., Laliberte C., Kaplan D.R., Unsicher K. ERK activation promotes neuronal degeneration predominantly through plasma membrane damage and independently of caspase-3. J. Cell Biol. 2004, 165:357-369.
17. Surendran S., Rajasankar S. Parkinson's disease: oxidative stress and therapeutic approaches. Neurol. Sci. 2010, 31:531-540.
18. Tao L., Li X., Zhang L., Tian J., Li X., Sun X., Li X., Jiang L., Zhang X., Chen J. Protective effect of tetrahydroxystilbene glucoside on 6-OHDA-induced apoptosis in PC12 cells through the ROS-NO pathway. PLoS ONE 2011, 6:e26055.
19. Xia Z., Dickens M., Raingeaud J., Davis R.J., Greenberg M.E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 1995, 270:1326-1331.
20. Zhang H., Mak S., Cui W., Li W., Han R., Hu S., Ye M., Pi R., Han Y. Tacrine(2)-ferulic acid, a novel multifunctional dimer, attenuates 6-hydroxydopamine-induced apoptosis in PC12 cells by activating Akt pathway. Neurochem. Int. 2011, 59:981-988.
21. Zhang R., Kang K.A., Piao M.J., Ko D.O., Wang Z.H., Chang W.Y., You H.J., Lee I.K., Kim B.J., Kang S.S., Hyun J.W. Preventive effect of 7,8-dihydroxyflavone against oxidative stress induced genotoxicity. Biol. Pharm. Bull. 2009, 32:166-171.
22. Zhu T.G., Wang X.X., Luo W.F., Zhang Q.L., Huang T.T., Xu X.S., Liu C.F. Protective effects of urate against 6-OHDA-induced cell injury in PC12 cells through antioxidant action. Neurosci. Lett. 2012, 506:175-179.