SPA0355 attenuates ischemia/reperfusion-induced liver injury in mice

Experimental and Molecular Medicine

Volumn 46, Issue 8, 2014, Pages

  Bae, Ui Jin ^a   Yang, Jae Do ^a   Ka, Sun O ^a   Koo, Jeung Hyun ^a   Woo, Seong Ji ^a   Lee, Young Rae ^b   Yu, Hee Chul ^a   Cho, Baik Hwan ^a   Zhao, Hui Yuan ^c   Ryu, Jae Ha ^c   Lee, Sang Myeong ^d   Jeon, Raok ^c   Park, Byung Hyun ^a  

^a Chonbuk National University Medical School   (South Korea)

^b Wonkwang University   (South Korea)

^c Sookmyung Women's University   (South Korea)

^d Chonbuk National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYL 3 [4 [2 PHENOXAZIN 10 YLETHOXY] PHENYL]THIOUREA; AMINOTRANSFERASE; CATALASE; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MALONALDEHYDE; SPA 0355; SUPEROXIDE DISMUTASE; THIOUREA DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; BENZOXAZINE DERIVATIVE; SPA0355; THIOUREA;

AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; C57BL 6 MOUSE; CELL DEATH; CONTROLLED STUDY; DNA BINDING; DOWN REGULATION; DRUG EFFICACY; GENE EXPRESSION; LIVER FUNCTION; LIVER INJURY; LIVER ISCHEMIA; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN TRANSPORT; PROTHROMBIN TIME; REPEATED DRUG DOSE; REPERFUSION INJURY; SHAM PROCEDURE; UPREGULATION; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; DRUG EFFECTS; IMMUNOLOGY; LIVER; PATHOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BENZOXAZINES; LIVER; MALE; MICE, INBRED C57BL; NF-KAPPA B; REPERFUSION INJURY; SIGNAL TRANSDUCTION; THIOUREA;

EID: 84906856672     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.2014.48     Document Type: Article

References (30)

1. Lentsch AB, Kato A, Yoshidome H, McMasters KM, Edwards MJ. Inflammatory mechanisms and therapeutic strategies for warm hepatic ischemia/reperfusion injury. Hepatology 2000; 32: 169-173.
2. Jaeschke H. Reactive oxygen and mechanisms of inflammatory liver injury: Present concepts. J Gastroenterol Hepatol 2011; 26: 173-179.
3. Jaeschke H, Farhood A. Neutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver. Am J Physiol 1991; 260: G355-G362.
4. Muriel P. Role of free radicals in liver diseases. Hepatol Int 2009; 3: 526-536.
5. Wanner GA, Ertel W, Muller P, Hofer Y, Leiderer R, Menger MD et al. Liver ischemia and reperfusion induces a systemic inflammatory response through Kupffer cell activation. Shock 1996; 5: 34-40.
6. Shibuya H, Ohkohchi N, Tsukamoto S, Satomi S. Tumor necrosis factorinduced, superoxide-mediated neutrophil accumulation in cold ischemic/reperfused rat liver. Hepatology 1997; 26: 113-120.
7. Jaeschke H, Farhood A, Smith CW. Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo. FASEB J 1990; 4: 3355-3359.
8. Peralta C, Jimenez-Castro MB, Gracia-Sancho J. Hepatic ischemia and reperfusion injury: Effects on the liver sinusoidal milieu. J Hepatol 2013; 59: 1094-1106.
9. Shin T, Kuboki S, Lentsch AB. Roles of nuclear factor-kB in postischemic liver. Hepatol Res 2008; 38: 429-440.
10. Cressman DE, Greenbaum LE, DeAngelis RA, Ciliberto G, Furth EE, Poli V et al. Liver failure and defective hepatocyte regeneration in interleukin-6- deficient mice. Science 1996; 274: 1379-1383.
11. Wang CY, Mayo MW, Korneluk RG, Goeddel DV, Baldwin Jr AS. NF-kB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 1998; 281: 1680-1683.
12. Luedde T, Assmus U, Wustefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M et al. Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. J Clin Invest 2005; 115: 849-859.
13. Rao J, Qian X, Wang P, Pu L, Zhai Y, Wang X et al. All-trans retinoic acid preconditioning protects against liver ischemia/reperfusion injury by inhibiting the nuclear factor kB signaling pathway. J Surg Res 2013; 180: e99-e106.
14. Suetsugu H, Iimuro Y, Uehara T, Nishio T, Harada N, Yoshida M et al. Nuclear factor kB inactivation in the rat liver ameliorates short term total warm ischaemia/reperfusion injury. Gut 2005; 54: 835-842.
15. Xu MQ, Shuai XR, Yan ML, Zhang MM, Yan LN. Nuclear factor-kB decoy oligodeoxynucleotides attenuates ischemia/reperfusion injury in rat liver graft. World J Gastroenterol 2005; 11: 6960-6967.
16. Lee YR, Hwang JK, Lee HS, Cheon YJ, Ryu JH, Lee SI et al. SPA0355, a thiourea analogue, inhibits inflammatory responses and joint destruction in fibroblast-like synoviocytes and mice with collagen-induced arthritis. Brit J Pharmacol 2011; 164: 794-806.
17. Bae UJ, Song MY, Jang HY, Jin Gim H, Ryu JH, Lee SM et al. The efficacy of SPA0355 in protecting b cells in isolated pancreatic islets and in a murine experimental model of type 1 diabetes. Exp Mol Med 2013; 45: e51.
18. Jaeschke H, Lemasters JJ. Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury. Gastroenterology 2003; 125: 1246-1257.
19. Llacuna L, Mari M, Lluis JM, Garcia-Ruiz C, Fernandez-Checa JC, Morales A. Reactive oxygen species mediate liver injury through parenchymal nuclear factor-kB inactivation in prolonged ischemia/reperfusion. Am J Pathol 2009; 174: 1776-1785.
20. Matsui N, Kasajima K, Hada M, Nagata T, Senga N, Yasui Y et al. Inhibiton of NF-kB activation during ischemia reduces hepatic ischemia/reperfusion injury in rats. J Toxicol Sci 2005; 30: 103-110.
21. Kuboki S, Sakai N, Clarke C, Schuster R, Blanchard J, Edwards MJ et al. The peptidyl-prolyl isomerase, Pin1, facilitates NF-kB binding in hepatocytes and protects against hepatic ischemia/reperfusion injury. J Hepatol 2009; 51: 296-306.
22. Okaya T, Lentsch AB. Hepatic expression of S32A/S36A IkBa does not reduce postischemic liver injury. J Surg Res 2005; 124: 244-249.
23. Yu J, Lee HS, Lee SM, Yu HC, Moon WS, Chung MJ et al. Aggravation of post-ischemic liver injury by overexpression of A20, an NF-kB suppressor. J Hepatol 2011; 55: 328-336.
24. He SQ, Zhang YH, Venugopal SK, Dicus CW, Perez RV, Ramsamooj R et al. Delivery of antioxidative enzyme genes protects against ischemia/reperfusion- induced liver injury in mice. Liver Transplant 2006; 12: 1869-1879.
25. Suzuki M, Takeuchi H, Kakita T, Unno M, Katayose Y, Matsuno S. The involvement of the intracellular superoxide production system in hepatic ischemia-reperfusion injury. In vivo and in vitro experiments using transgenic mice manifesting excessive CuZn-SOD activity. Free Radic Biol Med 2000; 29: 756-763.
26. Schauer RJ, Gerbes AL, Vonier D, Meissner H, Michl P, Leiderer R et al. Glutathione protects the rat liver against reperfusion injury after prolonged warm ischemia. Ann Surg 2004; 239: 220-231.
27. Uchida Y, Freitas MC, Zhao D, Busuttil RW, Kupiec-Weglinski JW. The protective function of neutrophil elastase inhibitor in liver ischemia/reperfusion injury. Transplantation 2010; 89: 1050-1056.
28. Akahori T, Sho M, Hamada K, Suzaki Y, Kuzumoto Y, Nomi T et al. Importance of peroxisome proliferator-activated receptor-g in hepatic ischemia/reperfusion injury in mice. J Hepatol 2007; 47: 784-792.
29. Chen YX, Sato M, Kawachi K, Abe Y. Neutrophil-mediated liver injury during hepatic ischemia-reperfusion in rats. Hepatob Pancreat Dis 2006; 5: 436-442.
30. Ke B, Shen XD, Gao F, Qiao B, Ji H, Busuttil RW et al. Small interfering RNA targeting heme oxygenase-1 (HO-1) reinforces liver apoptosis induced by ischemia-reperfusion injury in mice: HO-1 is necessary for cytoprotection. Hum Gene Ther 2009; 20: 1133-1142.