De novo transcriptome sequencing and digital gene expression analysis predict biosynthetic pathway of rhynchophylline and isorhynchophylline from Uncaria rhynchophylla, a non-model plant with potent anti-alzheimer's properties

BMC Genomics

Volumn 15, Issue 1, 2014, Pages

  Guo, Qianqian ^a,b   Ma, Xiaojun ^c,d   Wei, Shugen ^e   Qiu, Deyou ^f   Wilson, Iain W ^g   Wu, Peng ^b   Tang, Qi ^h   Liu, Lijun ^a   Dong, Shoukun ^a   Zu, Wei ^a  

^a NORTHEAST AGRICULTURAL UNIVERSITY   (China)

^b QIQIHAR UNIVERSITY   (China)

^c INSTITUTE OF MEDICINAL PLANT DEVELOPMENT   (China)

^d PEKING UNION MEDICAL COLLEGE   (China)

^e Guangxi Medicinal Botanical Garden ^*  (China)

^f RESEARCH INSTITUTE OF FORESTRY   (China)

^g CSIRO   (Australia)

^h HUNAN AGRICULTURAL UNIVERSITY   (China)

Author keywords

DGE; Isorhynchophylline; Rhynchophylline; Terpene indole alkaloid biosynthesis; Transcriptome; Uncaria rhynchophylla

Indexed keywords

ALKALOID; COMPLEMENTARY DNA; CYTOCHROME P450; ISOMERASE; ISORHYNCHOPHYLLINE; METHYLTRANSFERASE; RHYNCHOPHYLLINE; TERPENE INDOLE ALKALOID; TRANSCRIPTOME; UNCLASSIFIED DRUG; INDOLE ALKALOID; RHYNCOPHYLLINE;

ALZHEIMER DISEASE; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; CYTOCHROME P450 GENE; DEVELOPMENTAL STAGE; DNA LIBRARY; DRUG DETERMINATION; DRUG POTENCY; DRUG STRUCTURE; ENZYME ASSAY; GENE EXPRESSION; GENE IDENTIFICATION; ISOMERASE GENE; METHYLTRANSFERASE GENE; NONHUMAN; PREDICTION; RNA SEQUENCE; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; UNCARIA; UNCARIA RHYNCHOPHYLLA; GENE EXPRESSION PROFILING; GENETICS; HIGH THROUGHPUT SEQUENCING; METABOLISM; MOLECULAR GENETICS; PLANT GENE; SEQUENCE HOMOLOGY;

UNCARIA RHYNCHOPHYLLA;

ALZHEIMER DISEASE; GENE EXPRESSION PROFILING; GENES, PLANT; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; INDOLE ALKALOIDS; MOLECULAR SEQUENCE ANNOTATION; SEQUENCE ANALYSIS, RNA; SEQUENCE HOMOLOGY, NUCLEIC ACID; UNCARIA;

EID: 84906826257     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-15-676     Document Type: Article

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