The use of genetics to dissect plant secondary pathways

Current Opinion in Plant Biology

Volumn 8, Issue 3 SPEC. ISS., 2005, Pages 230-235

  Memelink, Johan ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ARABIDOPSIS; ARABIDOPSIS THALIANA;

EID: 18044388420     PISSN: 13695266     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbi.2005.03.003     Document Type: Review

References (36)

1. B. Winkel-Shirley It takes a garden. How work on diverse plant species has contributed to an understanding of flavonoid metabolism Plant Physiol 127 2001 1399 1404
2. K.M. Davies, and K.E. Schwinn Transcriptional regulation of secondary metabolism Funct Plant Biol 30 2003 913 925
3. M.A. Marles, H. Ray, and M.Y. Gruber New perspectives on proanthocyanidin biochemistry and molecular regulation Phytochemistry 64 2003 367 383
4. D. Baulcombe RNA silencing in plants Nature 431 2004 356 363
5. C.M. McCallum, L. Comai, E.A. Greene, and S. Henikoff Target induced local lesions in genomes (TILLING) for plant functional genomics Plant Physiol 123 2000 439 442
6. M. Ruegger, and C. Chapple Mutations that reduce sinapoylmalate accumulation in Arabidopsis thaliana define loci with diverse roles in phenylpropanoid metabolism Genetics 159 2001 1741 1749
7. M. Koornneef, C. Alonso-Blanco, and D. Vreugdenhil Naturally occurring genetic variation in Arabidopsis thaliana Annu Rev Plant Biol 55 2004 141 172
8. U. Wittstock, and B.A. Halkier Glucosinolate research in the Arabidopsis era Trends Plant Sci 7 2002 263 270
9. S. Chen, E. Glawischnig, K. Jorgensen, P. Naur, B. Jorgensen, C.E. Olsen, C.H. Hansen, H. Rasmussen, J.A. Pickett, and B.A. Halkier CYP79F1 and CYP79F2 have distinct functions in the biosynthesis of aliphatic glucosinolates in Arabidopsis Plant J 33 2003 923 937
10. T. Tantikanjana, M.D. Mikkelsen, M. Hussain, B.A. Halkier, and V. Sundaresan Functional analysis of the tandem-duplicated P450 genes SPS/BUS/CYP79F1 and CYP79F2 in glucosinolate biosynthesis and plant development by Ds transposition-generated double mutants Plant Physiol 135 2004 840 848
11. M.R. Hemm, M.O. Ruegger, and C. Chapple The Arabidopsis ref2 mutant is defective in the gene encoding CYP83A1 and shows both phenylpropanoid and glucosinolate phenotypes Plant Cell 15 2003 179 194
12. M.D. Mikkelsen, P. Naur, and B.A. Halkier Arabidopsis mutants in the C-S lyase of glucosinolate biosynthesis establish a critical role for indole-3-acetaldoxime in auxin homeostasis Plant J 37 2004 770 777
13. D.C. Grubb, B.J. Zipp, J. Ludwig-Muller, M.N. Masuno, T.F. Molinski, and S. Abel Arabidopsis glucosyltransferase UGT74B1 functions in glucosinolate biosynthesis and auxin homeostasis Plant J 40 2004 893 908
14. E. Glawischnig, B.G. Hansen, C.E. Olsen, and B.A. Halkier Camalexin is synthesized from indole-3-acetaldoxime, a key branching point between primary and secondary metabolism in Arabidopsis Proc Natl Acad Sci USA 101 2004 8245 8250
15. J.L. Celenza, J.A. Quiel, G.A. Smolen, H. Merrikh, A.R. Silvestro, J. Normanly, and J. Bender The Arabidopsis ATR1 Myb transcription factor controls indolic glucosinolate homeostasis Plant Physiol 137 2005 253 262 Further analysis of ATR1 function shows that this transcription factor regulates not only genes in tryptophan biosynthesis but also several genes in indole glucosinolate biosynthesis.
16. G. Smolen, and J. Bender Arabidopsis cytochrome P450 cyp83B1 mutations activate the tryptophan biosynthetic pathway Genetics 160 2002 323 332
17. I. Barlier, M. Kowalczyk, A. Marchant, K. Ljung, R. Bhalerao, M. Bennett, G. Sandberg, and C. Bellini The SUR2 gene of Arabidopsis thaliana encodes the cytochrome P450 CYP83B1, a modulator of auxin homeostasis Proc Natl Acad Sci USA 97 2000 14819 14824
18. G. Schoch, S. Goepfert, M. Morant, A. Hehn, D. Meyer, P. Ullmann, and D. Werck-Reichhart CYP98A3 from Arabidopsis thaliana is a 3′-hydroxylase of phenolic esters, a missing link in the phenylpropanoid pathway J Biol Chem 276 2001 36566 36574
19. R. Franke, J.M. Humphreys, M.R. Hemm, J.W. Denault, M.O. Ruegger, J.C. Cusumano, and C. Chapple The Arabidopsis REF8 gene encodes the 3-hydroxylase of phenylpropanoid metabolism Plant J 30 2002 33 45
20. R.B. Nair, K.L. Bastress, M.O. Ruegger, J.W. Denault, and C. Chapple The Arabidopsis thaliana REDUCED EPIDERMAL FLUORESCENCE1 gene encodes an aldehyde dehydrogenase involved in ferulic acid and sinapic acid biosynthesis Plant Cell 16 2004 544 554 Analysis of the ref1 mutant overturns existing views on intermediate to end-product relationships in phenylpropanoid metabolism. In the revised view, ferulate and sinapate feature as end products rather than as intermediates.
21. M. Devic, J. Guilleminot, I. Debeaujon, N. Bechtold, E. Bensaude, M. Koornneef, G. Pelletier, and M. Delseny The BANYULS gene encodes a DFR-like protein and is a marker of early seed coat development Plant J 19 1999 387 398
22. D.Y. Xie, S.B. Sharma, N.L. Paiva, D. Ferreira, and R.A. Dixon Role of anthocyanidin reductase, encoded by BANYULS in plant flavonoid biosynthesis Science 299 2003 396 399
23. N. Nesi, C. Jond, I. Debeaujon, M. Caboche, and L. Lepiniec The Arabidopsis TT2 gene encodes an R2R3 MYB domain protein that acts as a key determinant for proanthocyanidin accumulation in developing seed Plant Cell 13 2001 2099 2114
24. N. Nesi, I. Debeaujon, C. Jond, G. Pelletier, M. Caboche, and L. Lepiniec The TT8 gene encodes a basic helix-loop-helix domain protein required for expression of DFR and BAN genes in Arabidopsis siliques Plant Cell 12 2000 1863 1878
25. A. Baudry, M.A. Heim, B. Dubreucq, M. Caboche, B. Weisshaar, and L. Lepiniec TT2, TT8, and TTG1 synergistically specify the expression of BANYULS and proanthocyanidin biosynthesis in Arabidopsis thaliana Plant J 39 2004 366 380
26. S. Kitamura, N. Shikazono, and A. Tanaka TRANSPARENT TESTA 19 is involved in the accumulation of both anthocyanins and proanthocyanidins in Arabidopsis Plant J 37 2004 104 114
27. A.G. Millgate, B.J. Pogson, I.W. Wilson, T.M. Kutchan, M.H. Zenk, W.L. Gerlach, A.J. Fist, and P.J. Larkin Morphine-pathway block in top1 poppies Nature 431 2004 413 414
28. J.O. Borevitz, Y. Xia, J. Blount, R.A. Dixon, and C. Lamb Activation tagging identifies a conserved MYB regulator of phenylpropanoid biosynthesis Plant Cell 12 2000 2383 2394
29. H. Mathews, S.K. Clendennen, C.G. Caldwell, X.L. Liu, K. Connors, N. Matheis, D.K. Schuster, D.J. Menasco, W. Wagoner, J. Lightner, and D.R. Wagner Activation tagging in tomato identifies a transcriptional regulator of anthocyanin biosynthesis, modification, and transport Plant Cell 15 2003 1689 1703 The authors of this paper once again demonstrate the power of T-DNA activation tagging for the discovery of regulators of secondary metabolism. Their work underlines the important roles of certain MYB family members in anthocyanin biosynthesis in different plant species.
30. L. van der Fits, and J. Memelink ORCA3, a jasmonate-responsive transcriptional regulator of plant primary and secondary metabolism Science 289 2000 295 297
31. L. van der Fits, and J. Memelink The jasmonate-inducible AP2/ERF-domain transcription factor ORCA3 activates gene expression via interaction with a jasmonate-responsive promoter element Plant J 25 2001 43 53
32. R. Saedler, and I.T. Baldwin Virus-induced gene silencing of jasmonate-induced direct defences, nicotine and trypsin proteinase-inhibitors in Nicotiana attenuata J Exp Bot 55 2004 151 157
33. A. Steppuhn, K. Gase, B. Krock, R. Halitschke, and I.T. Baldwin Nicotine's defensive function in nature PLoS Biol 2 2004 e217
34. Chintapakorn Y, Hamill JD: Antisense-mediated down-regulation of putrescine N-methyltransferase activity in transgenic Nicotiana tabacum L. can lead to elevated levels of anatabine at the expense of nicotine. Plant Mol Biol 53:87-105.
35. R.S. Allen, A.G. Millgate, J.A. Chitty, J. Thisleton, J.A. Miller, A.J. Fist, W.L. Gerlach, and P.J. Larkin RNAi-mediated replacement of morphine with the nonnarcotic alkaloid reticuline in opium poppy Nat Biotechnol 22 2004 1559 1566 This paper provides a nice example of how drastic changes in metabolite patterns in a non-model species can be achieved using an RNAi approach. It also uncovers a previously unknown aspect of morphine biosynthesis: there appears to be a metabolic coupling between the terminal seven reaction steps.
36. D. Vom Endt, J.W. Kijne, and J. Memelink Transcription factors controlling plant secondary metabolism: what regulates the regulators? Phytochemistry 61 2002 107 114