Anti-inflammatory effects of rhynchophylline and isorhynchophylline in mouse N9 microglial cells and the molecular mechanism

International Immunopharmacology

Volumn 9, Issue 13-14, 2009, Pages 1549-1554

  Yuan, Dan ^a   Ma, Bin ^a   Yang, Jing yu ^a   Xie, Yuan yuan ^a   Wang, Li ^a   Zhang, Li jia ^a   Kano, Yoshihiro ^a   Wu, Chun fu ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Anti inflammation; iNOS; Microglia; Oxindole alkaloid; Signaling pathway; TNF and IL 1

Indexed keywords

I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; ISORHYNCHOPHYLLINE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; RHYNCHOPHYLLINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; ENZYME PHOSPHORYLATION; IMMUNOSUPPRESSIVE TREATMENT; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STROKE; UNCARIA;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; DRUGS, CHINESE HERBAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; I-KAPPA B PROTEINS; INDOLE ALKALOIDS; INTERLEUKIN-1BETA; ISOMERISM; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHYTOTHERAPY; SIGNAL TRANSDUCTION; STROKE; TUMOR NECROSIS FACTOR-ALPHA; UNCARIA;

EID: 70350572886     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2009.09.010     Document Type: Article

References (45)

1. McGeer P.L., Kawamata T., Walker D.G., Akiyama H., Tooyama I., and McGeer E.G. Microglia in degenerative neurological disease. Glia 7 (1993) 84-92
2. Combs C.K., Karlo J.C., Kao S.C., and Landreth G.E. Beta-Amyloid stimulation of microglia and monocytes results in TNF-alpha dependent expression of inducible nitric oxide synthase and neuronal apoptosis. J Neurosci 21 (2001) 1179-1188
3. Urushitani M., Shimohama S., Kihara T., Sawada H., Akaike A., Ibi M., et al. Mechanism of selective motor neuronal death after exposure of spinal cord to glutamate: involvement of glutamateinduced nitric oxide in motor neuron toxicity and nonmotor neuron protection. Ann Neurol 44 (1998) 796-807
4. Chao C.C., Hu S., Molitor T.W., and Shaskan E.G. Peterson PK.Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J Immunology 149 (1992) 2736-2741
5. Bensky D., Gamble A., and Kaptchuk T. Chinese Herbal Medicine: Material Medica. Revised ed (1999), Eastland press, Califonia (USA) 423
6. Shimada Y., Terasawa K., Yamamoto T., Maruyama I., Saitoh Y., Kanaki E., et al. A well-controlled study of Choto-san and placebo in the treatment of vascular dementia. J Tradit Med 11 (1994) 246-255
7. Tang W., and Eisenbrand G. Chinese Drugs of Plant Origin: Chemistry, Pharmacology, and Use in Traditional and Modern Medicine (1992), Springer-Verlag, Berlin (Germany 1056
8. Ozaki Y. Pharmacological studies of indole alkaloids obtained from domestic plants, Uncaria rhynchophylla Miq. and Amsonia elliptica Roem. et Schult. Nippon Yakurigaku Zasshi 94 (1989) 17-26
9. Kuramochi T., Chu J., and Suga T. Gou-teng (from Uncaria rhynchophylla Miquel)-induced endotheliumdependent and -independent relaxations in the isolated rataorta. Life Sci 54 (1994) 2061-2069
10. Chen C.X., Jin R.M., Li Y.K., Zhong J., Yue L., Chen S.C., et al. Inhibitory effect of rhynchophylline on platelet aggregation and thrombosis. Zhongguo Yaoli Xuebao 13 (1992) 126-130
11. Terasawa K., Shimada Y., Kita T., Yamamoto T., Tosa H., Tanaka N., et al. Choto-san in the treatment of vascular dementia: a double-blind, placebo-controlled study. Phytomedicine 4 (1997) 15-22
12. Watanabe H., Zhao Q., Matsumoto K., Tohda M., Murakami Y., Zhang S.H., et al. Pharmacological evidence for antidementia effect of Choto-san (Gouteng-san), a traditional Kampo medicine. Pharmacol Biochem Behav 75 (2003) 635-643
13. Suk K., Kim S.Y., Leem K., Kim Y.O., Park S.Y., Hur J., et al. Neuroprotection by methanol extract of Uncaria rhynchophylla against global cerebral ischemia in rats. Life Sci 70 (2002) 2467-2480
14. Kang T.H., Murakami Y., Takayama H., Kitajima M., Aimi N., Watanabe H., et al. Protective effect of rhynchophylline and isorhynchophylline on in vitro ischemia-induced neuronal damage in the hippocampus: putative neurotransmitter receptors involved in their action. Life Sci 76 (2004) 331-343
15. Shimada Y., Goto H., Itoh T., Sakakibara I., Kubo M., Sasaki H., et al. Evaluation of the protective effects of alkaloids isolated from the hooks and stems of Uncaria sinensis on glutamate-induced neuronal death in cultured cerebellar granule cells from rats. J Pharm Pharmacol 51 (1999) 715-722
16. Shi J.S., and Kenneth H.G. Effect of rhynchophylline on apoptosis induced by dopamine in NT2 cells. Acta Pharmacol Sin 23 (2002) 445-449
17. Matsumoto K., Morishige R., Murakami Y., Tohda M., Takayama H., Sakakibara I., et al. Suppressive effects of isorhynchophylline on 5-HT2A receptor function in the brain: behavioural and electrophysiological studies. Eur J Pharmacol 517 (2005) 191-199
18. Kanatani H., Kohda H., Yamasaki K., Hotta I., Nakata Y., Segawa T., et al. The active principle of the branchlets and hook of Uncaria sinensis Oliv. examined with a 5-hydroxytryptamine receptor-binding assay. J Pharm Pharmacol 37 (1985) 401-404
19. Yuan D., Ma B., Wu C., Yang J., Zhang L., Liu S., et al. Alkaloids from the leaves of Uncaria rhynchophylla and their inhibitory activity on NO production in lipopolysaccharide-activated microglia. J Nat Prod 71 (2008) 1271-1274
20. Chang J.Y., Chavis J.A., Liu L.Z., and Drew P.D. Cholesterol oxides induce programmed cell death in microglial cells. Biochem Biophys Res Commun 249 (1998) 817-821
21. Barger S.W., and Harmon A.D. Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E. Nature 388 (1997) 878-881
22. Bi X.L., Yang J.Y., Dong Y.X., Wang J.M., Cui Y.H., Ikeshimad T., et al. Resveratrol inhibits nitric oxide and TNF-α production by lipopolysaccharide-activated microglia. Int Immunopharmacol 5 (2005) 185-193
23. Mémet S. NF-κB functions in the nervous system: from development to disease. Biochem Pharmacol 72 (2006) 1180-1195
24. Hayden M.S., and Ghosh S. Signaling to NF-kappaB. Genes Dev 18 (2004) 2195-2224
25. Bhat N.R., and Fan F. Adenovirus infection induces microglial activation: involvement of mitogen-activated protein kinase pathways. Brain Res 948 (2002) 93-101
26. Waetzig V., Czeloth K., Hidding U., Mielke K., Kanzow M., Brecht S., et al. c-Jun N-terminal kinases (JNKs) mediate pro-inflammatory actions of microglia. Glia 50 (2005) 235-246
27. Bal-Price A., and Brown G.C. Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity. J Neurosci 21 (2001) 6480-6491
28. Hu S., Peterson P.K., and Chao C.C. Cytokine-mediated neuronal apoptosis. Neurochem Int 30 (1997) 427-431
29. Hirsch E.C., Breidert T., Rousselet E., Hunot S., Hartmann A., and Michel P.P. The role of glial reaction and inflammation in Parkinson's disease. Ann NY Acad Sci 991 (2003) 214-228
30. Chew L.J., Takanohashi A., and Bell M. Microglia and inflammation: impact on developmental brain injuries. Ment Retard Dev Disabil 12 (2006) 105-112
31. Hobbs A.J., Higgs A., and Moncada S. Inhibition of nitric oxide synthase as a potential therapeutic target. Annu Rev Pharmacol Toxicol 39 (1999) 191-220
32. Karunakaran S., and Ravindranath V. Activation of p38 MAPK in the substantia nigra leads to nuclear translocation of NF-kappaB in MPTP-treated mice: implication in Parkinson's disease. J Neurochem 109 (2009) 1791-1799
33. Shen S., Yu S., and Binek J. Distinct signaling pathways for induction of type II NOS by IFN-γ and LPS in BV-2 microglial cells. Neuroscience 22 (2005) 3352-3358
34. Bugaud F., Nadal-Wollbold F., Lévy-Toledano S., Rosa J.P., and Bryckaert M. Regulation of c-jun-NH2 terminal kinase and extracellular-signal regulated kinase in human platelets. Blood 94 11 (1999) 3800-3805
35. Hsieh C.L., Ho T.Y., Su S.Y., Lo W.Y., Liu C.H., and Tang N.Y. Uncaria rhynchophylla and rhynchophylline inhibit c-Jun N-terminal kinase phosphorylation and nuclear factor-κB activity in kainicacid-treated rats. Am J Chin Med 37 2 (2009) 351-360
36. 2+]i responses in human microglia by the peripheral benzodiazepine receptor ligand PK11195. J Neurochem 83 (2002) 546-555
37. Hoffmann A., Kann O., Ohlemeyer C., Hanisch U.K., and Kettenmann H. Elevation of basal intracellular calcium as a central element in the activation of brain macrophages (microglia): Suppression of receptor evoked calcium signaling and control of release function. J Neurosci 23 (2003) 4410-4419
38. 2+]i transients and changes the organization of actin in microglia. Glia 11 (1994) 336-344
39. Draheim H.J., Prinz M., Weber J.R., Weiser T., Kettenmann H., and Hanisch U.K. Induction of potassium channels in mouse brain microglia: Cells acquire responsiveness to pneumococcal cell wall components during late development. Neuroscience 89 (1999) 1379-1390
40. + channels in activated microglia in vivo. Glia 24 (1998) 408-414
41. Wang X.L., Zhang L.M., and Hua Z. Blocking effect of rhynchophylline on calcium channels in isolated rat ventricular myocytes. Zhongguo Yaoli Xuebao 15 2 (1994) 115-118
42. Wang X.L., Zhang L.M., and Hua Z. Effect of rhyncophylline on potassium channels in isolated rat or guinea pig ventricular myocytes. Yao Xue Xue Bao 29 1 (1994) 9-14
43. Yamahara J., Miki S., Matsuda H., Kobayashi G., and Fujimura H. Screening test for calcium antagonist in natural products. The active principles of Uncariae ramulus et uncus. Nippon Yakurigaku Zasshi 90 (1987) 133-140
44. Chou C.H., Gong C.L., Chao C.C., Lin C.H., Kwan C.Y., Hsieh C.L., et al. Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K + channels. J Nat Prod 72 (2009) 830-834
45. Huang B., Wu Q., Wen G., Lu Y., and Shi J. The distribution of isorhynchophylline in the tissues of the rats and the determination of its plasma half-life time. Acta Academiae Medicinae Zunyi 2 (2001)