Investigation of maternal and fetal exposure to an IgG2 monoclonal antibody following biweekly intravaginal administration to cynomolgus monkeys throughout pregnancy

Reproductive Toxicology

Volumn 48, Issue , 2014, Pages 132-137

  Moffat, Graeme J ^a   Davies, Rhian ^a   Kwon, Gayle ^a   Retter, Marc W ^b   Chellman, Gary J ^c   Kanapuram, Sekhar ^b   Moore, Meghan ^b   Loomis, Mark ^b   Wang, Wei ^b   Pyrah, Ian T G ^b  

^a AMGEN INC   (United States)

^b AMGEN INC   (United States)

^c CHARLES RIVER LABORATORIES   (United States)

Author keywords

Human risk; Monoclonal antibody; Vaginal absorption

Indexed keywords

IGG2 MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG; IMMUNOGLOBULIN G;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EXPOSURE; DRUG UPTAKE; ENVIRONMENTAL EXPOSURE; FEMALE; GESTATION PERIOD; LIMIT OF QUANTITATION; MACACA FASCICULARIS; MATERNAL BLOOD; NONHUMAN; PREGNANCY; PRENATAL EXPOSURE; ANIMAL; BLOOD; FETOMATERNAL TRANSFUSION; FETUS BLOOD; INTRAVAGINAL DRUG ADMINISTRATION; MALE; METABOLISM; SPERM;

MACACA FASCICULARIS;

ADMINISTRATION, INTRAVAGINAL; ANIMALS; ANTIBODIES, MONOCLONAL; FEMALE; FETAL BLOOD; IMMUNOGLOBULIN G; MACACA FASCICULARIS; MALE; MATERNAL EXPOSURE; MATERNAL-FETAL EXCHANGE; PREGNANCY; SEMEN;

EID: 84906790477     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2014.05.003     Document Type: Article

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