Cervicovaginal evaluation in macaques used as a model for topical microbicide safety studies

Journal of Medical Primatology

Volumn 37, Issue SUPPL.1, 2008, Pages 65-73

  Scorpio, Diana G ^a   Ruben, Dawn S ^a   Liao, Zhaohao ^a   Hildreth, James E ^b   Fletcher, Craig A ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b MEHARRY MEDICAL COLLEGE   (United States)

Author keywords

Cervix; Colposcopy; Non human primate; Rhesus; Vaginal pH

Indexed keywords

MICROBICIDE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; BACTERIUM CULTURE; COLPOSCOPY; CONFERENCE PAPER; CONTROLLED STUDY; CREAM; DIAGNOSTIC PROCEDURE; DRUG EFFICACY; DRUG SAFETY; EPITHELIUM CELL; ERYTHROCYTE; FEMALE; GEL; LAVAGE; LEUKOCYTE; MACACA; METHODOLOGY; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL; SEDATION; UTERINE CERVIX BIOPSY; UTERINE CERVIX CYTOLOGY;

ADMINISTRATION, INTRAVAGINAL; ANIMALS; ANTI-INFECTIVE AGENTS; BACTERIA; BIOPSY; CERVIX UTERI; COLPOSCOPY; FEMALE; HYDROGEN-ION CONCENTRATION; IRRIGATION; MACACA MULATTA; MODELS, ANIMAL; VAGINA;

MACACA; MACACA MULATTA; PRIMATES;

EID: 39049169472     PISSN: 00472565     EISSN: 16000684     Source Type: Journal    
DOI: 10.1111/j.1600-0684.2007.00265.x     Document Type: Conference Paper

References (13)

1. Abel K, Rourke T, Lu D, Bost K, McChesney MB, Miller CJ: Abrogation of attenuated lentivirus-induced protection in rhesus macaques by administration of Depo-Provera before intravaginal challenge with simian immunodeficiency virus mac239. J Infect Dis 2004; 190:1697-705.
2. Bradford M: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye-binding. Anal Biochem 1976; 72:248-54.
3. De Los Santos GE, Zuniga S: Comparison of pH measurement devices for determining vaginal pH in cynomolgus macaques. Contemp Top Lab Anim Sci 2004; 43:39-40.
4. Doyle L, Young CL, Jang SS, Hillier SL: Normal vaginal aerobic and anaerobic bacterial flora of the rhesus macaque (Macaca mulatta). J Med Primatol 1991; 20:409-13.
5. Howett MK, Kuhl JP: Microbicides for prevention of transmission of sexually transmitted diseases. Curr Pharmaceut Design 2005; 11:3731-46.
6. Keller MJ, Zerhouni-Layachi B, Cheshenko N, John M, Hogarty K, Kasowitz A, Goldberg CL, Wallenstein S, Profy AT, Klotman ME, Herold BC: PRO 2000 gel inhibits HIV and herpes simplex virus infection following vaginal application: A double-blind placebo-controlled trial. J Infect Dis 2006; 193:27-35.
7. Lederman MM, Offord RE, Hartley O: Microbicides and other topical strategies to prevent vaginal transmission of HIV. Nat Rev Immunol 2006; 6:371-82.
8. Lu FX, Ma Z, Rourke T, Srinivasan S, McChesney M, Miller CJ: Immunoglobulin concentrations and antigen-specific antibody levels in cervicovaginal lavages of rhesus macaques are influenced by the stage of the menstrual cycle. Infect Immun 1999; 67: 6321-8.
9. Patton DL, Cosgrove Sweeney YT, McCarthy TD, Hillier SL: Preclinical safety and efficacy assessments of dendrimer-based (SPL7013) microbicide gel formulations in a nonhuman primate model. Antimicrob Agents Chemother 2006; 50:1696-700.
10. Patton DL, Sweeney YC, Tsai CC, Hillier SL: Macaca fascicularis vs. Macaca nemestrina as a model for topical microbicide safety studies. J Med Primatol 2004; 33:105-8.
11. Poonia B, Walter L, Dufour J, Harrison R, Marx PA, Veazey RS: Cyclic changes in the vaginal epithelium of normal rhesus macaques. J Endocrinol 2006; 190:829-35.
12. Van Voorhis BJ: Genitourinary symptoms in the menopausal transition. Am J Med 2005; 118(Suppl 12B):47-53.
13. World Heath Organization/CONRAD: Manual for the Standardization of Colposcopy for the Evaluation of Vaginal Products, update 2004. Geneva, 2004.