Placental transfer of a fully human IgG2 monoclonal antibody in the cynomolgus monkey, rat, and rabbit: A comparative assessment from during organogenesis to late gestation

Birth Defects Research Part B - Developmental and Reproductive Toxicology

Volumn 101, Issue 2, 2014, Pages 178-188

  Moffat, Graeme J ^a   Retter, Marc W ^b   Kwon, Gayle ^a   Loomis, Mark ^b   Hock, M Benjamin ^b   Hall, Colin ^a   Bussiere, Jeanine ^b   Lewis, Elise M ^c   Chellman, Gary J ^c  

^a AMGEN INC   (United States)

^b AMGEN INC   (United States)

^c CHARLES RIVER LABORATORIES   (United States)

Author keywords

Human risk; Monoclonal antibody; Placental transfer; Species differences

Indexed keywords

IMMUNOGLOBULIN G2; MONOCLONAL ANTIBODY; IMMUNOGLOBULIN G;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FEMALE; IMMUNOGENICITY; MACACA FASCICULARIS; NONHUMAN; ORGANOGENESIS; PLACENTAL TRANSFER; PRIORITY JOURNAL; RABBIT; RAT; SPECIES DIFFERENCE; THIRD TRIMESTER PREGNANCY; ANIMAL; ANIMAL EMBRYO; DOSE RESPONSE; DRUG EFFECTS; EMBRYOLOGY; FETOMATERNAL TRANSFUSION; FETUS; GESTATIONAL AGE; METABOLISM; PLACENTA; PREGNANCY; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIBODIES, MONOCLONAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO, MAMMALIAN; FEMALE; FETUS; GESTATIONAL AGE; IMMUNOGLOBULIN G; MACACA FASCICULARIS; MATERNAL EXPOSURE; MATERNAL-FETAL EXCHANGE; ORGANOGENESIS; PLACENTA; PREGNANCY; RABBITS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84898678031     PISSN: 15429733     EISSN: 15429741     Source Type: Journal    
DOI: 10.1002/bdrb.21105     Document Type: Article

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