Structural basis for the recruitment and activation of the Legionella phospholipase VipD by the host GTPase Rab5

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 34, 2014, Pages

  Lucas, María ^a   Gaspar, Andrew H ^b   Pallara, Chiara ^c   Rojas, Adriana Lucely ^a   Fernańdez Recio, Juan ^c   Machner, Matthias P ^b   Hierro, Aitor ^a,d  

^a CIC BIOGUNE   (Spain)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c BARCELONA SUPERCOMPUTING CENTER   (Spain)

^d BASQUE FOUNDATION FOR SCIENCE   (Spain)

Author keywords

Allosteric modulation; Membrane composition; Pathogenic bacteria; X ray crystallography

Indexed keywords

AMINO ACID; INHIBITOR PROTEIN; MUTANT PROTEIN; PHOSPHOLIPASE; RAB PROTEIN; UNCLASSIFIED DRUG; VACUOLAR PROTEIN SORTING INHIBITOR PROTEIN D; BACTERIAL PROTEIN; MULTIPROTEIN COMPLEX; PHOSPHOLIPASE A1; RECOMBINANT PROTEIN; VESICULAR TRANSPORT PROTEIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYST; CELLULAR DISTRIBUTION; CRYSTAL STRUCTURE; ENZYME ACTIVATION; GEL FILTRATION CHROMATOGRAPHY; HOST CELL; LEGIONELLA PNEUMOPHILA; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; PROTEIN TARGETING; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING COMPETITION; CHEMICAL STRUCTURE; CHEMISTRY; ENDOSOME; ENZYME ACTIVE SITE; ENZYMOLOGY; GENETICS; HOST PATHOGEN INTERACTION; HUMAN; METABOLISM; MOLECULAR DYNAMICS; MOLECULAR GENETICS; PATHOGENICITY; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN QUATERNARY STRUCTURE; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; BINDING, COMPETITIVE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENDOSOMES; HOST-PATHOGEN INTERACTIONS; HUMANS; LEGIONELLA PNEUMOPHILA; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MULTIPROTEIN COMPLEXES; MUTAGENESIS, SITE-DIRECTED; PHOSPHOLIPASES A1; PROTEIN CONFORMATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, QUATERNARY; RAB5 GTP-BINDING PROTEINS; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; VESICULAR TRANSPORT PROTEINS;

EID: 84906699384     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1405391111     Document Type: Article

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