Multiple domains are required for the toxic activity of Pseudomonas aeruginosa ExoU

Journal of Bacteriology

Volumn 183, Issue 14, 2001, Pages 4330-4344

  Finck Barbancon V ^a   Frank, D W ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; PROTEIN EXOU; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DEATH; CELL MEMBRANE PERMEABILITY; CHO CELL; CONTROLLED STUDY; CORRELATION FUNCTION; CYTOTOXICITY; GENE CONSTRUCT; GENETIC TRANSFECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN STRUCTURE; PSEUDOMONAS AERUGINOSA;

ANIMALS; BACTERIAL PROTEINS; BACTERIAL TOXINS; BINDING SITES; CELL MEMBRANE PERMEABILITY; CHO CELLS; CRICETINAE; CYTOTOXINS; GENE EXPRESSION; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; LUMINESCENT PROTEINS; OLIGOPEPTIDES; PSEUDOMONAS AERUGINOSA; RECOMBINANT FUSION PROTEINS;

BACTERIA (MICROORGANISMS); CRICETINAE; CRICETULUS GRISEUS; EXOS; NEGIBACTERIA; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA;

EID: 0034977803     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.183.14.4330-4344.2001     Document Type: Article

References (42)

1. Acquisition of expression of the Pseudomonas aeruginosa ExoU cytotoxin leads to increased bacterial virulence in a murine model of acute pneumonia and systemic spread
2. Characterization of Pseudomonas aeruginosa-induced MDCK cell injury: Glycosylation defective host cells are resistant to bacterial killing
3. Identification of an amino terminal substrate-binding domain in the Yersinia tyrosine phosphatase that is required for efficient recognition of focal adhesion targets
4. Macrophages and epithelial cells respond differently to the Pseudomonas aeruginosa type III-secretion system
5. Acid-induced dissociation of VacA, the Helicobacter pylori vacuolating cytotoxin, reveals its pattern of assembly
6. Pseudomonas aeruginosa cystic fibrosis isolates induce rapid, type III secretion-dependent, but ExoU-independent, oncosis of macrophages and polymorphonuclear neutrophils
7. A complex composed of SycN and YscB functions as a specific chaperone for YopN in Yersinia pestis
8. ExoU expression by Pseudomonas aeruginosa correlates with acute cytotoxicity and epithelial injury
9. Identification and characterization of SpcU, a chaperone required for efficient secretion of the ExoU cytotoxin
10. Pseudomonas aeruginosa-mediated cytotoxicity and invasion correlate with distinct genotypes at the loci encoding exoenzyme S
11. The exoenzyme S regulon of Pseudomonas aeruginosa
12. Construction and characterization of chromosomal insertions of the Pseudomonas aeruginosa trans-regulatory locus
13. The eukaryotic host factor that activates exoenzyme S of Pseudomonas aeruginosa is a member of the 14-3-3 protein family
14. The Salmonella typhimurium tyrosine phosphatase SptP is translocated into host cells and disrupts the actin cytoskeleton
15. Pseudomonas aeruginosa exoenzyme S ADP-ribosylates Ras at multiple sites
16. Pseudomonas aeruginosa exoenzyme S, a double ADP-ribosyl transferase, resembles vertebrate mono-ADP-ribosyl transferases
17. The N-terminal domain of Pseudomonas aeruginosa is a GTPase-activating protein for Rho GTPases
18. Pseudomonas aeruginosa induces type III-secretion-mediated apoptosis of macrophages and epithelial cells
19. PepA, a secreted protein of Pseudomonas aeruginosa, is necessary for cytotoxicity and virulence
20. Identification of Pseudomonas aeruginosa genes required for epithelial cell injury
21. Functional domains of Pseudomonas aeruginosa exoenzyme S
22. Exoproduct secretions of Pseudomonas aeruginosa strains influence severity of alveolar epithelial injury
23. Purification and characterization of exoenzyme S from Pseudomonas aeruginosa 388
24. Expression of recombinant exoenzyme S of Pseudomonas aeruginosa
25. Pathogenesis of septic shock in Pseudomonas aeruginosa pneumonia
26. Modification of Ras in eukaryotic cells by Pseudomonas aeruginosa exoenzyme S
27. YopJ of Yersinia spp. is sufficient to cause downregulation of multiple mitogen-activated protein kinases in eukaryotic cells
28. Intracellular expression of the ADP-ribosyltransferase domain of Pseudomonas aeruginosa exoenzyme S is cytotoxic to eukaryotic cells
29. The amino-terminal domain of Pseudomonas aeruginosa exoenzyme S disrupts actin filaments via small-molecular-weight GTP-binding proteins
30. Towards deciphering the Helicobacter pylori cytotoxin
31. In vitro cellular toxicity predicts Pseudomonas aeruginosa virulence in lung infections
32. Active and passive immunization with the Pseudomonas V antigen protects against type III intoxication and lung injury
33. Identification of the YopE and YopH domains required for secretion and internalization into the cytosol of macrophages, using the cyaA gene fusion approach
34. Biological effects of Pseudomonas aeruginosa type III-secreted proteins on CHO cells
35. Regulation of ExoS production and secretion by Pseudomonas aeruginosa in response to tissue culture conditions
36. ADP-ribosylation of oncogenic Ras proteins by Pseudomonas aeruginosa exoenzyme S in vivo
37. Identification of a promoter-specific transactivation domain in the herpes simplex virus regulatory protein ICP4
38. Pertussis toxin-mediated ADP-ribosylation of target proteins in Chinese hamster ovary cells involves a vesicle trafficking mechanism
39. Exoenzyme S of Pseudomonas aeruginosa is secreted by a type III pathway
40. Identification of type III secreted products of the Pseudomonas aeruginosa exoenzyme S regulon
41. ExoY, an adenylate cyclase secreted by the Pseudomonas aeruginosa type III system
42. Identification of the minimal intracellular vacuolating domain of the Helicobacter pylori vacuolating toxin