12486-12491 Tumorigenicity of hypoxic respiring cancer cells revealed by a hypoxia-cell cycle dual reporter

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 34, 2014, Pages 12486-12491

  Le, Anne ^a   Stine, Zachary E ^b   Nguyen, Christopher ^a   Afzal, Junaid ^a   Sun, Peng ^a   Hamaker, Max ^a   Siegel, Nicholas M ^a   Gouw, Arvin M ^a   Kang, Byung Hak ^a   Yu, Shu Han ^a   Cochran, Rory L ^a   Sailor, Kurt A ^a   Song, Hongjun ^a   Dang, Chi V ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Antiangiogenesis; Metabolism; Mitochondria

Indexed keywords

BEVACIZUMAB; CELL CYCLE PROTEIN; HYPOXIA AND CELL CYCLE REPORTER; HYPOXIA INDUCIBLE FACTOR; UNCLASSIFIED DRUG; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PHOTOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CARCINOGENICITY; CELL CYCLE M PHASE; CELL HYPOXIA; CELL POPULATION; CELL PROLIFERATION; CELL RESPIRATION; CELL SUBPOPULATION; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA STRAND BREAKAGE; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; GLYCOLYSIS; HYPOXIC CELL; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; REOXYGENATION; S PHASE CELL CYCLE CHECKPOINT; TUMOR BLOOD FLOW; TUMOR MICROENVIRONMENT; ANIMAL; BIOLOGICAL MODEL; CANCER TRANSPLANTATION; CELL CYCLE; GENETICS; HEK293 CELL LINE; HUMAN; MALE; METABOLISM; MITOCHONDRIAL GENE; NEOPLASM; NUDE MOUSE; ONCOGENE; PATHOLOGY; PHYSIOLOGY; REPORTER GENE; XENOGRAFT;

ANIMALS; CELL CYCLE; CELL HYPOXIA; CELL RESPIRATION; GENE EXPRESSION; GENES, MITOCHONDRIAL; GENES, REPORTER; HEK293 CELLS; HETEROGRAFTS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LUMINESCENT PROTEINS; MALE; MICE; MICE, NUDE; MODELS, BIOLOGICAL; NEOPLASM TRANSPLANTATION; NEOPLASMS; ONCOGENES; OXYGEN CONSUMPTION;

EID: 84906691259     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1402012111     Document Type: Article

References (30)

1. Dang CV (2012) Links between metabolism and cancer. Genes Dev 26(9):877-890.
2. Vander Heiden MG, Cantley LC, Thompson CB (2009) Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science 324(5930):1029-1033.
3. Cairns RA, Harris IS, Mak TW (2011) Regulation of cancer cell metabolism. Nat Rev Cancer 11(2):85-95.
4. Keith B, Johnson RS, Simon MC (2012) HIF1α and HIF2α: Sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer 12(1):9-22.
5. Semenza GL (2012) Hypoxia-inducible factors: Mediators of cancer progression and targets for cancer therapy. Trends Pharmacol Sci 33(4):207-214.
6. Koppenol WH, Bounds PL, Dang CV (2011) Otto Warburg's contributions to current concepts of cancer metabolism. Nat Rev Cancer 11(5):325-337.
7. Fogal V, et al. (2010) Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation. Mol Cell Biol 30(6):1303-1318.
8. Le A, et al. (2012) Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab 15(1):110-121.
9. Sonveaux P, et al. (2008) Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J Clin Invest 118(12):3930-3942.
10. Chandel NS, Budinger GR, Choe SH, Schumacker PT (1997) Cellular respiration during hypoxia: Role of cytochrome oxidase as the oxygen sensor in hepatocytes. J Biol Chem 272(30):18808-18816. (Pubitemid 27318228)
11. Raman V, et al. (2006) Characterizing vascular parameters in hypoxic regions: A combined magnetic resonance and optical imaging study of a human prostate cancer model. Cancer Res 66(20):9929-9936. (Pubitemid 44672045)
12. Dewhirst MW, Cao Y, Moeller B (2008) Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nat Rev Cancer 8(6):425-437. (Pubitemid 351744964)
13. Kimura H, et al. (1996) Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma. Cancer Res 56(23):5522-5528. (Pubitemid 27011389)
14. Sakaue-Sawano A, et al. (2008) Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. Cell 132(3):487-498. (Pubitemid 351191996)
15. Gardner LB, et al. (2001) Hypoxia inhibits G1/S transition through regulation of p27 expression. J Biol Chem 276(11):7919-7926.
16. Green SL, Freiberg RA, Giaccia AJ (2001) p21(Cip1) and p27(Kip1) regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest. Mol Cell Biol 21(4):1196-1206. (Pubitemid 32114968)
17. Hubbi ME, et al. (2013) A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication. Sci Signal 6(262):ra10.
18. Hu CJ, Sataur A, Wang L, Chen H, Simon MC (2007) The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha. Mol Biol Cell 18(11):4528-4542. (Pubitemid 350060179)
19. Eisen MB, Spellman PT, Brown PO, Botstein D (1998) Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA 95(25):14863-14868. (Pubitemid 29003722)
20. Subramanian A, et al. (2005) Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 102(43):15545-15550. (Pubitemid 41528093)
21. Liu YC, et al. (2008) Global regulation of nucleotide biosynthetic genes by c-Myc. PLoS ONE 3(7):e2722.
22. Seltzer MJ, et al. (2010) Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. Cancer Res 70(22):8981-8987.
23. DeLaBarre B, et al. (2011) Full-length human glutaminase in complex with an allosteric inhibitor. Biochemistry 50(50):10764-10770.
24. Zhang J, et al. (2012) Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells. Nat Protoc 7(6):1068-1085.
25. Arteel GE, Thurman RG, Yates JM, Raleigh JA (1995) Evidence that hypoxia markers detect oxygen gradients in liver: Pimonidazole and retrograde perfusion of rat liver. Br J Cancer 72(4):889-895.
26. Farwell MD, Pryma DA, Mankoff DA (2014) PET/CT imaging in cancer: Current applications and future directions. Cancer, 10.1002/cncr.28860.
27. Weisshardt P, et al. (2012) Tumor vessel stabilization and remodeling by anti-angiogenic therapy with bevacizumab. Histochem Cell Biol 137(3):391-401.
28. Weinberg F, et al. (2010) Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity. Proc Natl Acad Sci USA 107(19):8788-8793.
29. Guo JY, et al. (2011) Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev 25(5):460-470.
30. Son J, et al. (2013) Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature 496(7443):101-105.