Two phase I dose-escalation/pharmacokinetics studies of low temperature liposomal doxorubicin (LTLD) and mild local hyperthermia in heavily pretreated patients with local regionally recurrent breast cancer

International Journal of Hyperthermia

Volumn 30, Issue 5, 2014, Pages 285-294

  Zagar, Timothy M ^a   Vujaskovic, Zeljko ^b   Formenti, Silvia ^c   Rugo, Hope ^d   Muggia, Franco ^c   O'Connor, Brigid ^e   Myerson, Robert ^f   Stauffer, Paul ^g   Hsu, I Chow ^d   Diederich, Chris ^d   Straube, William ^f   Boss, Mary Keara ^h   Boico, Alina ^g   Craciunescu, Oana ^g   Maccarini, Paolo ⁱ   Needham, David ^g   Borys, Nicholas ^j   Blackwell, Kimberly L ^g   Dewhirst, Mark W ^g  

^a UNIVERSITY OF NORTH CAROLINA HOSPITALS   (United States)

^b UNIVERSITY OF MARYLAND MEDICAL CENTER   (United States)

^c NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e RHODE ISLAND HOSPITAL   (United States)

^f WASHINGTON UNIVERSITY   (United States)

^g DUKE UNIVERSITY MEDICAL CENTER   (United States)

^h NORTH CAROLINA STATE UNIVERSITY   (United States)

ⁱ Duke University   (United States)

^j Celsion   (United States)

more..

Author keywords

Hyperthermia; Low temperature liposomal doxorubicin; Recurrent breast cancer

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTHRACYCLINE; DOXORUBICIN; DOXORUBICINOL; EPIRUBICIN; HEMOGLOBIN; THERMODOX; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; MACROGOL DERIVATIVE;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANEMIA; ARTICLE; BACKACHE; BONE MARROW TOXICITY; BREAST ADENOCARCINOMA; CANCER CHEMOTHERAPY; CANCER HORMONE THERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CELLULITIS; CLINICAL ARTICLE; DEHYDRATION; DISTANT METASTASIS; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG FEVER; DRUG HALF LIFE; DRUG HYPERSENSITIVITY; DRUG MEGADOSE; DRUG SAFETY; DRUG WITHDRAWAL; FATIGUE; FEMALE; HEART LEFT VENTRICLE EJECTION FRACTION; HEMOGLOBIN BLOOD LEVEL; HUMAN; HYPERTHERMIC THERAPY; HYPOKALEMIA; LEUKOCYTE COUNT; LEUKOPENIA; LOW TEMPERATURE; LYMPHEDEMA; LYMPHOCYTOPENIA; MAXIMUM PLASMA CONCENTRATION; MAXIMUM TOLERATED DOSE; MILD LOCAL HYPERTHERMIA; MULTIPLE CYCLE TREATMENT; MUSCULOSKELETAL CHEST PAIN; MUSCULOSKELETAL PAIN; NEUTROPENIA; NEUTROPHIL COUNT; ONCO HYPERTHERMIA DEVICE; OVERALL SURVIVAL; PARTIAL THROMBOPLASTIN TIME; PHASE 1 CLINICAL TRIAL; PLASMA CLEARANCE; RADIATION DOSE; SIDE EFFECT; SINGLE DRUG DOSE; THERMAL INJURY; THORAX WALL; THROMBOCYTOPENIA; TREATMENT RESPONSE; ADENOCARCINOMA; AGED; ANALOGS AND DERIVATIVES; BLOOD; BREAST NEOPLASMS; CLINICAL TRIAL; MIDDLE AGED; MULTICENTER STUDY; MULTIMODALITY CANCER THERAPY; TEMPERATURE; THERMOTHERAPY; TREATMENT OUTCOME; TUMOR RECURRENCE;

ADENOCARCINOMA; ADULT; AGED; ANTIBIOTICS, ANTINEOPLASTIC; BREAST NEOPLASMS; COMBINED MODALITY THERAPY; DOXORUBICIN; FEMALE; HUMANS; HYPERTHERMIA, INDUCED; MAXIMUM TOLERATED DOSE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; POLYETHYLENE GLYCOLS; TEMPERATURE; TREATMENT OUTCOME;

EID: 84906667095     PISSN: 02656736     EISSN: 14645157     Source Type: Journal    
DOI: 10.3109/02656736.2014.936049     Document Type: Article

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