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Volumn 7, Issue 10, 2012, Pages

Comparison of Conventional Chemotherapy, Stealth Liposomes and Temperature-Sensitive Liposomes in a Mathematical Model

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; LIPOSOME; STEALTH LIPOSOME; TEMPERATURE SENSITIVE LIPOSOME; UNCLASSIFIED DRUG;

EID: 84867637665     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047453     Document Type: Article
Times cited : (84)

References (48)
  • 1
    • 0030478388 scopus 로고    scopus 로고
    • Pharmacokinetic-toxicodynamic relationships of adriamycin in rat: prediction of butylated hydroxyanisole-mediated reduction in anthracycline cardiotoxicity
    • Vora J, Boroujerdi M, (1996) Pharmacokinetic-toxicodynamic relationships of adriamycin in rat: prediction of butylated hydroxyanisole-mediated reduction in anthracycline cardiotoxicity. J Pharm Pharmacol 48: 1264-1269.
    • (1996) J Pharm Pharmacol , vol.48 , pp. 1264-1269
    • Vora, J.1    Boroujerdi, M.2
  • 2
    • 0001852505 scopus 로고    scopus 로고
    • Anthracyclines and Anthracenediones
    • Chabner B.A., editor. 4th ed. Philadelphia: Lippincott Williams & Wilkins
    • Doroshow JH (2006) Anthracyclines and Anthracenediones. In: Chabner B.A., editor. Cancer chemotherapy and biotherapy: principles and practice. 4th ed. Philadelphia: Lippincott Williams & Wilkins.
    • (2006) Cancer chemotherapy and biotherapy: Principles and practice
    • Doroshow, J.H.1
  • 3
    • 0028349925 scopus 로고
    • Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes
    • Gabizon A, Catane R, Uziely B, Kaufman B, Safra T, et al. (1994) Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes. Cancer Res 54: 987-992.
    • (1994) Cancer Res , vol.54 , pp. 987-992
    • Gabizon, A.1    Catane, R.2    Uziely, B.3    Kaufman, B.4    Safra, T.5
  • 4
    • 26444500499 scopus 로고    scopus 로고
    • Determination of doxorubicin levels in whole tumor and tumor nuclei in murine breast cancer tumors
    • Laginha KM, Verwoert S, Charrois GJ, Allen TM, (2005) Determination of doxorubicin levels in whole tumor and tumor nuclei in murine breast cancer tumors. Clin Cancer Res 11: 6944-6949.
    • (2005) Clin Cancer Res , vol.11 , pp. 6944-6949
    • Laginha, K.M.1    Verwoert, S.2    Charrois, G.J.3    Allen, T.M.4
  • 5
    • 18244362593 scopus 로고    scopus 로고
    • Anti-CD19-targeted liposomal doxorubicin improves the therapeutic efficacy in murine B-cell lymphoma and ameliorates the toxicity of liposomes with varying drug release rates
    • Allen TM, Mumbengegwi DR, Charrois GJ, (2005) Anti-CD19-targeted liposomal doxorubicin improves the therapeutic efficacy in murine B-cell lymphoma and ameliorates the toxicity of liposomes with varying drug release rates. Clin Cancer Res 11: 3567-3573.
    • (2005) Clin Cancer Res , vol.11 , pp. 3567-3573
    • Allen, T.M.1    Mumbengegwi, D.R.2    Charrois, G.J.3
  • 7
    • 0035028214 scopus 로고    scopus 로고
    • Long-circulating vectors for the systemic delivery of genes
    • Fenske DB, MacLachlan I, Cullis PR, (2001) Long-circulating vectors for the systemic delivery of genes. Curr Opin Mol Ther 3: 153-158.
    • (2001) Curr Opin Mol Ther , vol.3 , pp. 153-158
    • Fenske, D.B.1    MacLachlan, I.2    Cullis, P.R.3
  • 8
    • 0031706663 scopus 로고    scopus 로고
    • Controlling the Drug Delivery Attributes of Lipid-Based Drug Formulations
    • Bally MB, Lim H, Cullis PR, Mayer LD, (1998) Controlling the Drug Delivery Attributes of Lipid-Based Drug Formulations. Journal of Liposome Research 8: 299-335.
    • (1998) Journal of Liposome Research , vol.8 , pp. 299-335
    • Bally, M.B.1    Lim, H.2    Cullis, P.R.3    Mayer, L.D.4
  • 9
    • 0018250922 scopus 로고
    • Design of liposomes for enhanced local release of drugs by hyperthermia
    • Yatvin MB, Weinstein JN, Dennis WH, Blumenthal R, (1978) Design of liposomes for enhanced local release of drugs by hyperthermia. Science 202: 1290-1293.
    • (1978) Science , vol.202 , pp. 1290-1293
    • Yatvin, M.B.1    Weinstein, J.N.2    Dennis, W.H.3    Blumenthal, R.4
  • 10
    • 0035981024 scopus 로고    scopus 로고
    • The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors
    • Needham D, Dewhirst MW, (2001) The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors. Adv Drug Deliv Rev 53: 285-305.
    • (2001) Adv Drug Deliv Rev , vol.53 , pp. 285-305
    • Needham, D.1    Dewhirst, M.W.2
  • 11
    • 77950338359 scopus 로고    scopus 로고
    • Triggered content release from optimized stealth thermosensitive liposomes using mild hyperthermia
    • Li L, ten Hagen TL, Schipper D, Wijnberg TM, van Rhoon GC, et al. (2010) Triggered content release from optimized stealth thermosensitive liposomes using mild hyperthermia. J Control Release 143: 274-279.
    • (2010) J Control Release , vol.143 , pp. 274-279
    • Li, L.1    ten Hagen, T.L.2    Schipper, D.3    Wijnberg, T.M.4    van Rhoon, G.C.5
  • 12
    • 0034671219 scopus 로고    scopus 로고
    • Efficacy of liposomes and hyperthermia in a human tumor xenograft model: importance of triggered drug release
    • Kong G, Anyarambhatla G, Petros WP, Braun RD, Colvin OM, et al. (2000) Efficacy of liposomes and hyperthermia in a human tumor xenograft model: importance of triggered drug release. Cancer Res 60: 6950-6957.
    • (2000) Cancer Res , vol.60 , pp. 6950-6957
    • Kong, G.1    Anyarambhatla, G.2    Petros, W.P.3    Braun, R.D.4    Colvin, O.M.5
  • 13
    • 77954390311 scopus 로고    scopus 로고
    • Mathematical spatio-temporal model of drug delivery from low temperature sensitive liposomes during radiofrequency tumour ablation
    • Gasselhuber A, Dreher MR, Negussie A, Wood BJ, Rattay F, et al. (2010) Mathematical spatio-temporal model of drug delivery from low temperature sensitive liposomes during radiofrequency tumour ablation. Int J Hyperthermia 26: 499-513.
    • (2010) Int J Hyperthermia , vol.26 , pp. 499-513
    • Gasselhuber, A.1    Dreher, M.R.2    Negussie, A.3    Wood, B.J.4    Rattay, F.5
  • 14
    • 65649146495 scopus 로고    scopus 로고
    • Lyso-thermosensitive liposomal doxorubicin: a novel approach to enhance efficacy of thermal ablation of liver cancer
    • Poon RT, Borys N, (2009) Lyso-thermosensitive liposomal doxorubicin: a novel approach to enhance efficacy of thermal ablation of liver cancer. Expert Opin Pharmacother 10: 333-343.
    • (2009) Expert Opin Pharmacother , vol.10 , pp. 333-343
    • Poon, R.T.1    Borys, N.2
  • 15
    • 34249008526 scopus 로고    scopus 로고
    • Pulsed-high intensity focused ultrasound and low temperature-sensitive liposomes for enhanced targeted drug delivery and antitumor effect
    • Dromi S, Frenkel V, Luk A, Traughber B, Angstadt M, et al. (2007) Pulsed-high intensity focused ultrasound and low temperature-sensitive liposomes for enhanced targeted drug delivery and antitumor effect. Clin Cancer Res 13: 2722-2727.
    • (2007) Clin Cancer Res , vol.13 , pp. 2722-2727
    • Dromi, S.1    Frenkel, V.2    Luk, A.3    Traughber, B.4    Angstadt, M.5
  • 17
    • 84861524634 scopus 로고    scopus 로고
    • Targeted drug delivery by high intensity focused ultrasound mediated hyperthermia combined with temperature-sensitive liposomes: Computational modelling and preliminary in vivo validation
    • Gasselhuber A, Dreher MR, Partanen A, Yarmolenko PS, Woods D, et al. (2012) Targeted drug delivery by high intensity focused ultrasound mediated hyperthermia combined with temperature-sensitive liposomes: Computational modelling and preliminary in vivo validation. Int J Hyperthermia 28: 337-348.
    • (2012) Int J Hyperthermia , vol.28 , pp. 337-348
    • Gasselhuber, A.1    Dreher, M.R.2    Partanen, A.3    Yarmolenko, P.S.4    Woods, D.5
  • 18
    • 33746067893 scopus 로고    scopus 로고
    • Phase I trial of doxorubicin-containing low temperature sensitive liposomes in spontaneous canine tumors
    • Hauck ML, LaRue SM, Petros WP, Poulson JM, Yu D, et al. (2006) Phase I trial of doxorubicin-containing low temperature sensitive liposomes in spontaneous canine tumors. Clin Cancer Res 12: 4004-4010.
    • (2006) Clin Cancer Res , vol.12 , pp. 4004-4010
    • Hauck, M.L.1    LaRue, S.M.2    Petros, W.P.3    Poulson, J.M.4    Yu, D.5
  • 19
    • 79951593867 scopus 로고    scopus 로고
    • Formulation and characterisation of magnetic resonance imageable thermally sensitive liposomes for use with magnetic resonance-guided high intensity focused ultrasound
    • Negussie AH, Yarmolenko PS, Partanen A, Ranjan A, Jacobs G,et al. Formulation and characterisation of magnetic resonance imageable thermally sensitive liposomes for use with magnetic resonance-guided high intensity focused ultrasound. Int J Hyperthermia 27: 140-155.
    • Int J Hyperthermia , vol.27 , pp. 140-155
    • Negussie, A.H.1    Yarmolenko, P.S.2    Partanen, A.3    Ranjan, A.4    Jacobs, G.5
  • 20
    • 34948817174 scopus 로고    scopus 로고
    • In vitro stability and content release properties of phosphatidylglyceroglycerol containing thermosensitive liposomes
    • Hossann M, Wiggenhorn M, Schwerdt A, Wachholz K, Teichert N, et al. (2007) In vitro stability and content release properties of phosphatidylglyceroglycerol containing thermosensitive liposomes. Biochim Biophys Acta 1768: 2491-2499.
    • (2007) Biochim Biophys Acta , vol.1768 , pp. 2491-2499
    • Hossann, M.1    Wiggenhorn, M.2    Schwerdt, A.3    Wachholz, K.4    Teichert, N.5
  • 21
    • 37349024980 scopus 로고    scopus 로고
    • Dual role of hexadecylphosphocholine (miltefosine) in thermosensitive liposomes: active ingredient and mediator of drug release
    • Lindner LH, Hossann M, Vogeser M, Teichert N, Wachholz K, et al. (2008) Dual role of hexadecylphosphocholine (miltefosine) in thermosensitive liposomes: active ingredient and mediator of drug release. J Control Release 125: 112-120.
    • (2008) J Control Release , vol.125 , pp. 112-120
    • Lindner, L.H.1    Hossann, M.2    Vogeser, M.3    Teichert, N.4    Wachholz, K.5
  • 22
    • 3142667914 scopus 로고    scopus 로고
    • The materials engineering of temperature-sensitive liposomes
    • Mills JK, Needham D, (2004) The materials engineering of temperature-sensitive liposomes. Methods Enzymol 387: 82-113.
    • (2004) Methods Enzymol , vol.387 , pp. 82-113
    • Mills, J.K.1    Needham, D.2
  • 23
    • 0033822142 scopus 로고    scopus 로고
    • A mathematical model for comparison of bolus injection, continuous infusion, and liposomal delivery of doxorubicin to tumor cells
    • El-Kareh AW, Secomb TW, (2000) A mathematical model for comparison of bolus injection, continuous infusion, and liposomal delivery of doxorubicin to tumor cells. Neoplasia 2: 325-338.
    • (2000) Neoplasia , vol.2 , pp. 325-338
    • El-Kareh, A.W.1    Secomb, T.W.2
  • 24
    • 58349108845 scopus 로고    scopus 로고
    • Predicting drug pharmacokinetics and effect in vascularized tumors using computer simulation
    • Sinek JP, Sanga S, Zheng X, Frieboes HB, Ferrari M, et al. (2008) Predicting drug pharmacokinetics and effect in vascularized tumors using computer simulation. J Math Biol.
    • (2008) J Math Biol.
    • Sinek, J.P.1    Sanga, S.2    Zheng, X.3    Frieboes, H.B.4    Ferrari, M.5
  • 25
    • 0037219540 scopus 로고    scopus 로고
    • Intracellular accumulation and mechanism of action of doxorubicin in a spatio-temporal tumor model
    • Jackson TL, (2003) Intracellular accumulation and mechanism of action of doxorubicin in a spatio-temporal tumor model. J Theor Biol 220: 201-213.
    • (2003) J Theor Biol , vol.220 , pp. 201-213
    • Jackson, T.L.1
  • 26
    • 77955243156 scopus 로고    scopus 로고
    • Numerical Study of Thermally Targeted Liposomal Drug Delivery in Tumor
    • Zhang A, Mi X, Yang G, Xu LX, (2009) Numerical Study of Thermally Targeted Liposomal Drug Delivery in Tumor. Journal of Heat Transfer 131: 043209-043210.
    • (2009) Journal of Heat Transfer , vol.131 , pp. 043209-043210
    • Zhang, A.1    Mi, X.2    Yang, G.3    Xu, L.X.4
  • 27
    • 23244457368 scopus 로고    scopus 로고
    • Two-mechanism peak concentration model for cellular pharmacodynamics of Doxorubicin
    • El-Kareh AW, Secomb TW, (2005) Two-mechanism peak concentration model for cellular pharmacodynamics of Doxorubicin. Neoplasia 7: 705-713.
    • (2005) Neoplasia , vol.7 , pp. 705-713
    • El-Kareh, A.W.1    Secomb, T.W.2
  • 28
    • 0032828135 scopus 로고    scopus 로고
    • Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols
    • Tofts PS, Brix G, Buckley DL, Evelhoch JL, Henderson E, et al. (1999) Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging 10: 223-232.
    • (1999) J Magn Reson Imaging , vol.10 , pp. 223-232
    • Tofts, P.S.1    Brix, G.2    Buckley, D.L.3    Evelhoch, J.L.4    Henderson, E.5
  • 29
    • 33644772618 scopus 로고    scopus 로고
    • Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers
    • Dreher MR, Liu W, Michelich CR, Dewhirst MW, Yuan F, et al. (2006) Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers. J Natl Cancer Inst 98: 335-344.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 335-344
    • Dreher, M.R.1    Liu, W.2    Michelich, C.R.3    Dewhirst, M.W.4    Yuan, F.5
  • 30
    • 0037133126 scopus 로고    scopus 로고
    • Targeting to macrophages: role of physicochemical properties of particulate carriers-liposomes and microspheres-on the phagocytosis by macrophages
    • Ahsan F, Rivas IP, Khan MA, Torres Suarez AI, (2002) Targeting to macrophages: role of physicochemical properties of particulate carriers-liposomes and microspheres-on the phagocytosis by macrophages. J Control Release 79: 29-40.
    • (2002) J Control Release , vol.79 , pp. 29-40
    • Ahsan, F.1    Rivas, I.P.2    Khan, M.A.3    Torres Suarez, A.I.4
  • 31
    • 73349142327 scopus 로고    scopus 로고
    • Evidence for in vivo macrophage mediated tumor uptake of paramagnetic/fluorescent liposomes
    • Castelli DD, Terreno E, Cabella C, Chaabane L, Lanzardo S, et al. (2009) Evidence for in vivo macrophage mediated tumor uptake of paramagnetic/fluorescent liposomes. NMR Biomed 22: 1084-1092.
    • (2009) NMR Biomed , vol.22 , pp. 1084-1092
    • Castelli, D.D.1    Terreno, E.2    Cabella, C.3    Chaabane, L.4    Lanzardo, S.5
  • 33
    • 0022509448 scopus 로고
    • Comparative intracellular uptake of adriamycin and 4′-deoxydoxorubicin by non-small cell lung tumor cells in culture and its relationship to cell survival
    • Kerr DJ, Kerr AM, Freshney RI, Kaye SB, (1986) Comparative intracellular uptake of adriamycin and 4′-deoxydoxorubicin by non-small cell lung tumor cells in culture and its relationship to cell survival. Biochem Pharmacol 35: 2817-2823.
    • (1986) Biochem Pharmacol , vol.35 , pp. 2817-2823
    • Kerr, D.J.1    Kerr, A.M.2    Freshney, R.I.3    Kaye, S.B.4
  • 34
    • 0024595338 scopus 로고
    • Correlation between growth inhibition and intranuclear doxorubicin and 4′-deoxy-4′-iododoxorubicin quantitated in living K562 cells by microspectrofluorometry
    • Gigli M, Rasoanaivo TW, Millot JM, Jeannesson P, Rizzo V, et al. (1989) Correlation between growth inhibition and intranuclear doxorubicin and 4′-deoxy-4′-iododoxorubicin quantitated in living K562 cells by microspectrofluorometry. Cancer Res 49: 560-564.
    • (1989) Cancer Res , vol.49 , pp. 560-564
    • Gigli, M.1    Rasoanaivo, T.W.2    Millot, J.M.3    Jeannesson, P.4    Rizzo, V.5
  • 35
    • 0025349837 scopus 로고
    • Comparative metabolism and pharmacokinetics of doxorubicin and 4′-epidoxorubicin in plasma, heart and tumor of tumor-bearing mice
    • van der Vijgh WJ, Maessen PA, Pinedo HM, (1990) Comparative metabolism and pharmacokinetics of doxorubicin and 4′-epidoxorubicin in plasma, heart and tumor of tumor-bearing mice. Cancer Chemother Pharmacol 26: 9-12.
    • (1990) Cancer Chemother Pharmacol , vol.26 , pp. 9-12
    • van der Vijgh, W.J.1    Maessen, P.A.2    Pinedo, H.M.3
  • 37
    • 0027292927 scopus 로고
    • Microvascular permeability of albumin, vascular surface area, and vascular volume measured in human adenocarcinoma LS174T using dorsal chamber in SCID mice
    • Yuan F, Leunig M, Berk DA, Jain RK, (1993) Microvascular permeability of albumin, vascular surface area, and vascular volume measured in human adenocarcinoma LS174T using dorsal chamber in SCID mice. Microvasc Res 45: 269-289.
    • (1993) Microvasc Res , vol.45 , pp. 269-289
    • Yuan, F.1    Leunig, M.2    Berk, D.A.3    Jain, R.K.4
  • 38
    • 0023219734 scopus 로고
    • Transport of molecules in the tumor interstitium: a review
    • Jain RK, (1987) Transport of molecules in the tumor interstitium: a review. Cancer Res 47: 3039-3051.
    • (1987) Cancer Res , vol.47 , pp. 3039-3051
    • Jain, R.K.1
  • 39
    • 48349143858 scopus 로고    scopus 로고
    • Effects of variation in perfusion rates and of perfusion models in computational models of radio frequency tumor ablation
    • Schutt DJ, Haemmerich D, (2008) Effects of variation in perfusion rates and of perfusion models in computational models of radio frequency tumor ablation. Med Phys 35: 3462-3470.
    • (2008) Med Phys , vol.35 , pp. 3462-3470
    • Schutt, D.J.1    Haemmerich, D.2
  • 40
    • 0028304405 scopus 로고
    • Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft
    • Yuan F, Leunig M, Huang SK, Berk DA, Papahadjopoulos D, et al. (1994) Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft. Cancer Res 54: 3352-3356.
    • (1994) Cancer Res , vol.54 , pp. 3352-3356
    • Yuan, F.1    Leunig, M.2    Huang, S.K.3    Berk, D.A.4    Papahadjopoulos, D.5
  • 41
    • 0024584819 scopus 로고
    • Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection
    • Baxter LT, Jain RK, (1989) Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection. Microvasc Res 37: 77-104.
    • (1989) Microvasc Res , vol.37 , pp. 77-104
    • Baxter, L.T.1    Jain, R.K.2
  • 42
    • 0027428561 scopus 로고
    • Measurement of material extravasation in microvascular networks using fluorescence video-microscopy
    • Wu NZ, Klitzman B, Rosner G, Needham D, Dewhirst MW, (1993) Measurement of material extravasation in microvascular networks using fluorescence video-microscopy. Microvasc Res 46: 231-253.
    • (1993) Microvasc Res , vol.46 , pp. 231-253
    • Wu, N.Z.1    Klitzman, B.2    Rosner, G.3    Needham, D.4    Dewhirst, M.W.5
  • 43
    • 14644399827 scopus 로고    scopus 로고
    • Advanced strategies in liposomal cancer therapy: problems and prospects of active and tumor specific drug release
    • Andresen TL, Jensen SS, Jorgensen K, (2005) Advanced strategies in liposomal cancer therapy: problems and prospects of active and tumor specific drug release. Prog Lipid Res 44: 68-97.
    • (2005) Prog Lipid Res , vol.44 , pp. 68-97
    • Andresen, T.L.1    Jensen, S.S.2    Jorgensen, K.3
  • 44
    • 0036282896 scopus 로고    scopus 로고
    • Doxorubicin pharmacokinetics: Macromolecule binding, metabolism, and excretion in the context of a physiologic model
    • Gustafson DL, Rastatter JC, Colombo T, Long ME, (2002) Doxorubicin pharmacokinetics: Macromolecule binding, metabolism, and excretion in the context of a physiologic model. J Pharm Sci 91: 1488-1501.
    • (2002) J Pharm Sci , vol.91 , pp. 1488-1501
    • Gustafson, D.L.1    Rastatter, J.C.2    Colombo, T.3    Long, M.E.4
  • 45
    • 0027242138 scopus 로고
    • Increased microvascular permeability contributes to preferential accumulation of Stealth liposomes in tumor tissue
    • Wu NZ, Da D, Rudoll TL, Needham D, Whorton AR, et al. (1993) Increased microvascular permeability contributes to preferential accumulation of Stealth liposomes in tumor tissue. Cancer Res 53: 3765-3770.
    • (1993) Cancer Res , vol.53 , pp. 3765-3770
    • Wu, N.Z.1    Da, D.2    Rudoll, T.L.3    Needham, D.4    Whorton, A.R.5
  • 46
    • 0343923453 scopus 로고    scopus 로고
    • Long-circulating liposomes for drug delivery in cancer therapy: a review of biodistribution studies in tumor-bearing animals
    • Gabizon A, (1997) Long-circulating liposomes for drug delivery in cancer therapy: a review of biodistribution studies in tumor-bearing animals. Advanced Drug Delivery Reviews 24: 337-344.
    • (1997) Advanced Drug Delivery Reviews , vol.24 , pp. 337-344
    • Gabizon, A.1
  • 47
    • 1342288382 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha augmented tumor response in B16BL6 melanoma-bearing mice treated with stealth liposomal doxorubicin (Doxil) correlates with altered Doxil pharmacokinetics
    • Brouckaert P, Takahashi N, van Tiel ST, Hostens J, Eggermont AM, et al. (2004) Tumor necrosis factor-alpha augmented tumor response in B16BL6 melanoma-bearing mice treated with stealth liposomal doxorubicin (Doxil) correlates with altered Doxil pharmacokinetics. Int J Cancer 109: 442-448.
    • (2004) Int J Cancer , vol.109 , pp. 442-448
    • Brouckaert, P.1    Takahashi, N.2    van Tiel, S.T.3    Hostens, J.4    Eggermont, A.M.5
  • 48
    • 55849109653 scopus 로고    scopus 로고
    • In vitro and in vivo evaluations of increased effective beam width for heat deposition using a split focus high intensity ultrasound (HIFU) transducer
    • Patel PR, Luk A, Durrani A, Dromi S, Cuesta J, et al. (2008) In vitro and in vivo evaluations of increased effective beam width for heat deposition using a split focus high intensity ultrasound (HIFU) transducer. Int J Hyperthermia 24: 537-549.
    • (2008) Int J Hyperthermia , vol.24 , pp. 537-549
    • Patel, P.R.1    Luk, A.2    Durrani, A.3    Dromi, S.4    Cuesta, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.