The Notch pathway controls fibrotic and regenerative repair in the adult heart

European Heart Journal

Volumn 35, Issue 32, 2014, Pages 2174-2185

  Nemir, Mohamed ^a   Metrich, Mélanie ^a   Plaisance, Isabelle ^a   Lepore, Mario ^a   Cruchet, Steeve ^a   Berthonneche, Corinne ^b   Sarre, Alexandre ^b   Radtke, Freddy ^c   Pedrazzini, Thierry ^a,b  

^a University of Lausanne Medical Center   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c EPFL   (Switzerland)

Author keywords

Cardiac precursor cells; Hypertrophy; Notch signalling; Regeneration

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BROXURIDINE; CALVASCULIN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; CONNECTIVE TISSUE GROWTH FACTOR; CYCLIN D1; FIBRONECTIN; GENOMIC DNA; INITIATION FACTOR 4E BINDING PROTEIN 1; JAGGED1; MAMMALIAN TARGET OF RAPAMYCIN; MYOSIN HEAVY CHAIN ALPHA; NOTCH RECEPTOR; PROTEIN KINASE B; PROTEIN S6; STEM CELL ANTIGEN 1; TAMOXIFEN; TRANSCRIPTION FACTOR NKX2.5; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA2; TRIPHENYLTETRAZOLIUM; CALCIUM BINDING PROTEIN; MEMBRANE PROTEIN; MTOR PROTEIN, MOUSE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PTEN PROTEIN, MOUSE; SERRATE PROTEINS; SIGNAL PEPTIDE; TARGET OF RAPAMYCIN KINASE; TRANSFORMING GROWTH FACTOR;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIAC STEM CELL; CELL DEATH; CELL EXPANSION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; FIBROSING ALVEOLITIS; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART REGENERATION; HEART SIZE; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE OVERLOAD; IMMUNOHISTOCHEMISTRY; MESENCHYMAL STROMA CELL; MOUSE; MYOFIBROBLAST; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; TISSUE REGENERATION; UPREGULATION; WESTERN BLOTTING; ANIMAL; CARDIOMEGALY; CELL SIZE; CYTOLOGY; FIBROSIS; HEART; HEART VENTRICLE REMODELING; HUMAN; LIGATION; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; REGENERATION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ANIMALS; CALCIUM-BINDING PROTEINS; CARDIOMEGALY; CELL PROLIFERATION; CELL SIZE; CONSTRICTION; FIBROSIS; HEART; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE, TRANSGENIC; MYOCYTES, CARDIAC; PHOSPHATIDYLINOSITOL 3-KINASES; PTEN PHOSPHOHYDROLASE; RECEPTORS, NOTCH; REGENERATION; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TRANSFORMING GROWTH FACTORS; VENTRICULAR REMODELING;

EID: 84906653542     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehs269     Document Type: Article

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