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Volumn 8, Issue 4, 2014, Pages 1271-1274

Ginsenoside compound K promotes β-amyloid peptide clearance in primary astrocytes via autophagy enhancement

Author keywords

Alzheimer's disease; Autophagy; Compound K; amyloid peptides

Indexed keywords

AMYLOID BETA PROTEIN; GINSENG EXTRACT; GINSENOSIDE COMPOUND K; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PROTEIN KINASE ULK1; PROTEIN P62; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

EID: 84906515229     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2014.1885     Document Type: Article
Times cited : (37)

References (20)
  • 2
    • 0032105394 scopus 로고    scopus 로고
    • The role of A beta 42 in Alzheimer's disease
    • Younkin SG: The role of A beta 42 in Alzheimer's disease. J Physiol Paris 92: 289-292, 1998.
    • (1998) J Physiol Paris , vol.92 , pp. 289-292
    • Younkin, S.G.1
  • 3
    • 0346055155 scopus 로고    scopus 로고
    • BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease
    • Ohno M, Sametsky EA, Younkin LH, et al: BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease. Neuron 41: 27-33, 2004.
    • (2004) Neuron , vol.41 , pp. 27-33
    • Ohno, M.1    Sametsky, E.A.2    Younkin, L.H.3
  • 4
    • 77958480110 scopus 로고    scopus 로고
    • Retinoic acid receptor-α signalling antagonizes both intracellular and extracellular amyloid-β production and prevents neuronal cell death caused by amyloid-β
    • Jarvis CI, Goncalves MB, Clarke E, et al: Retinoic acid receptor-α signalling antagonizes both intracellular and extracellular amyloid-β production and prevents neuronal cell death caused by amyloid-β. Eur J Neurosci 32: 1246-1255, 2010.
    • (2010) Eur J Neurosci , vol.32 , pp. 1246-1255
    • Jarvis, C.I.1    Goncalves, M.B.2    Clarke, E.3
  • 5
    • 79955941709 scopus 로고    scopus 로고
    • Selective dihydropyiridine compounds facilitate the clearance of β-amyloid across the blood-brain barrier
    • Bachmeier C, Beaulieu-Abdelahad D, Mullan M and Paris D: Selective dihydropyiridine compounds facilitate the clearance of β-amyloid across the blood-brain barrier. Eur J Pharmacol 659: 124-129, 2011.
    • (2011) Eur J Pharmacol , vol.659 , pp. 124-129
    • Bachmeier, C.1    Beaulieu-Abdelahad, D.2    Mullan, M.3    Paris, D.4
  • 6
    • 80052706430 scopus 로고    scopus 로고
    • Demonstration of safety in Alzheimer's patients for intervention with an anti-hypertensive drug Nilvadipine: Results from a 6-week open label study
    • Kennelly SP, Abdullah L, Paris D, et al: Demonstration of safety in Alzheimer's patients for intervention with an anti-hypertensive drug Nilvadipine: results from a 6-week open label study. Int J Geriatr Psychiatry 26: 1038-1045, 2011.
    • (2011) Int J Geriatr Psychiatry , vol.26 , pp. 1038-1045
    • Kennelly, S.P.1    Abdullah, L.2    Paris, D.3
  • 7
    • 0034537290 scopus 로고    scopus 로고
    • Autophagy as a regulated pathway of cellular degradation
    • Klionsky DJ and Emr SD: Autophagy as a regulated pathway of cellular degradation. Science 290: 1717-1721, 2000.
    • (2000) Science , vol.290 , pp. 1717-1721
    • Klionsky, D.J.1    Emr, S.D.2
  • 8
    • 84881173817 scopus 로고    scopus 로고
    • Arctigenin effectively ameliorates memory impairment in Alzheimer's disease model mice targeting both β-amyloid production and clearance
    • Zhu Z, Yan J, Jiang W, et al: Arctigenin effectively ameliorates memory impairment in Alzheimer's disease model mice targeting both β-amyloid production and clearance. J Neurosci 33: 13138-13149, 2013.
    • (2013) J Neurosci , vol.33 , pp. 13138-13149
    • Zhu, Z.1    Yan, J.2    Jiang, W.3
  • 9
    • 77956305343 scopus 로고    scopus 로고
    • Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease
    • Spilman P, Podlutskaya N, Hart MJ, et al: Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One 5: e9979, 2010.
    • (2010) PLoS One , vol.5
    • Spilman, P.1    Podlutskaya, N.2    Hart, M.J.3
  • 10
    • 84880078074 scopus 로고    scopus 로고
    • Characteristic study on the chemical components of Korean curved ginseng products
    • Cho CW, Kim YC, Kang JH, et al: Characteristic study on the chemical components of Korean curved ginseng products. J Ginseng Res 37: 349-354, 2013.
    • (2013) J Ginseng Res , vol.37 , pp. 349-354
    • Cho, C.W.1    Kim, Y.C.2    Kang, J.H.3
  • 11
    • 84902436989 scopus 로고    scopus 로고
    • Antioxidative effects of Korean red ginseng in postmenopausal women: A double-blind randomized controlled trial
    • Seo SK, Hong Y, Yun BH, et al: Antioxidative effects of Korean red ginseng in postmenopausal women: A double-blind randomized controlled trial. J Ethnopharmacol 154: 753-757, 2014.
    • (2014) J Ethnopharmacol , vol.154 , pp. 753-757
    • Seo, S.K.1    Hong, Y.2    Yun, B.H.3
  • 12
    • 84864773402 scopus 로고    scopus 로고
    • Effects of ginsenoside Rg1 or 17β-estradiol on a cognitively impaired, ovariectomized rat model of Alzheimer's disease
    • Zhang X, Wang J, Xing Y, et al: Effects of ginsenoside Rg1 or 17β-estradiol on a cognitively impaired, ovariectomized rat model of Alzheimer's disease. Neuroscience 220: 191-200, 2012.
    • (2012) Neuroscience , vol.220 , pp. 191-200
    • Zhang, X.1    Wang, J.2    Xing, Y.3
  • 13
    • 0032577217 scopus 로고    scopus 로고
    • An intestinal bacterial metabolite of ginseng protopanaxadiol saponins has the ability to induce apoptosis in tumor cells
    • Wakabayashi C, Murakami K, Hasegawa H, Murata J and Saiki I: An intestinal bacterial metabolite of ginseng protopanaxadiol saponins has the ability to induce apoptosis in tumor cells. Biochem Biophys Res Commun 246: 725-730, 1998.
    • (1998) Biochem Biophys Res Commun , vol.246 , pp. 725-730
    • Wakabayashi, C.1    Murakami, K.2    Hasegawa, H.3    Murata, J.4    Saiki, I.5
  • 14
    • 84862777666 scopus 로고    scopus 로고
    • ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models
    • Cramer PE, Cirrito JR, Wesson DW, et al: ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models. Science 335: 1503-1506, 2012.
    • (2012) Science , vol.335 , pp. 1503-1506
    • Cramer, P.E.1    Cirrito, J.R.2    Wesson, D.W.3
  • 15
    • 77951221542 scopus 로고    scopus 로고
    • The role of the Atg1/ULK1 complex in autophagy regulation
    • Mizushima N: The role of the Atg1/ULK1 complex in autophagy regulation. Curr Opin Cell Biol 22: 132-139, 2010.
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 132-139
    • Mizushima, N.1
  • 16
    • 33745192802 scopus 로고    scopus 로고
    • Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
    • Hara T, Nakamura K, Matsui M, et al: Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441: 885-889, 2006.
    • (2006) Nature , vol.441 , pp. 885-889
    • Hara, T.1    Nakamura, K.2    Matsui, M.3
  • 17
    • 84882254367 scopus 로고    scopus 로고
    • The role of autophagy in neurodegenerative disease
    • Nixon RA: The role of autophagy in neurodegenerative disease. Nat Med 19: 983-997, 2013.
    • (2013) Nat Med , vol.19 , pp. 983-997
    • Nixon, R.A.1
  • 18
    • 79251556232 scopus 로고    scopus 로고
    • Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation
    • Vingtdeux V, Chandakkar P, Zhao H, et al: Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation. FASEB J 25: 219-231, 2011.
    • (2011) FASEB J , vol.25 , pp. 219-231
    • Vingtdeux, V.1    Chandakkar, P.2    Zhao, H.3
  • 19
    • 84877333097 scopus 로고    scopus 로고
    • Latrepirdine (Dimebon®), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model
    • Steele JW and Gandy S: Latrepirdine (Dimebon®), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model. Autophagy 9: 617-618, 2013.
    • (2013) Autophagy , vol.9 , pp. 617-618
    • Steele, J.W.1    Gandy, S.2
  • 20
    • 84898542999 scopus 로고    scopus 로고
    • Geniposide ameliorates learning memory deficits, reduces tau phosphorylation and decreases apoptosis via GSK3β pathway in streptozotocin-induced alzheimer rat model
    • Gao C, Liu Y, Jiang Y, Ding J and Li L: Geniposide ameliorates learning memory deficits, reduces tau phosphorylation and decreases apoptosis via GSK3β pathway in streptozotocin-induced alzheimer rat model. Brain Pathol 24: 261-269, 2014.
    • (2014) Brain Pathol , vol.24 , pp. 261-269
    • Gao, C.1    Liu, Y.2    Jiang, Y.3    Ding, J.4    Li, L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.