Overexpression of the MUC2 gene through promoter hypomethylation in mucinous cell carcinomas and signet ring cell carcinomas of gastric cancer

Genes and Genomics

Volumn 32, Issue 5, 2010, Pages 429-435

  Bae, Han Ik ^a   Li, Ying Hua ^a   Na, Yeon Kyeong ^a   Jung, Young Won ^a   Lee, Su Man ^a   Yang, Jae Sub ^b   Kim, Dong Sun ^a  

^a Kyungpook National University School of Medicine   (South Korea)

^b Daegu University   (South Korea)

Author keywords

Gastric carcinoma; Hypomethylation; IHC; MSP; MUC2; Overexpression; Proximal promoter

Indexed keywords

GENOMIC DNA; MUCIN 2;

ARTICLE; CANCER GENETICS; CANCER TISSUE; COLLOID CARCINOMA; CONTROLLED STUDY; CPG ISLAND; CYTOPLASM; DNA METHYLATION; GENE OVEREXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; METHYLATION SPECIFIC POLYMERASE CHAIN REACTION; MUCINOUS CELL CARCINOMA; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PROMOTER REGION; SIGNET RING CARCINOMA; STOMACH CARCINOGENESIS; STOMACH CARCINOMA; STOMACH MUCOSA; TUMOR DIFFERENTIATION;

EID: 84906362586     PISSN: 19769571     EISSN: 20929293     Source Type: Journal    
DOI: 10.1007/s13258-010-0051-4     Document Type: Article

References (32)

1. Akyurek N, Akyol G, Dursun A, Yamac D and Gunel N (2002) Expression of MUC1 and MUC2 mucins in gastric carcinomas: their relationship with clinicopathologicparameters and prognosis. Pathol. Res. Pract. 198: 665-74.
2. Andrianifahanana M, Moniaux N and Batra SK (2006) Regulation of mucin expression: mechanistic aspects and implications for cancer and inflammatory disease. Biochim. Biophys. Acta. 1765: 189-222.
3. Baldus SE, Zirbes TK, Engel S, Hanisch FG, Monig SP, Lorenzen J, Glossmann J, Fromm S, Thiele J, Pichlmaier H and Dienes HP (1998) Correlation of the immunohistochemical reactivity of mucin peptide cores MUC1 and MUC2 with histopathological subtype and prognosis of gastric carcinomas. Int. J. Cancer 79: 133-8.
4. Catalano V, Labianca R, Beretta GD, Gatta G, de Braud F and Van Cutsem E (2009) Gastric cancer. Crit. Rev. Oncol. Hematol. 71: 127-64.
5. Choi IS and Wu TT (2005) Epigenetic alterations in gastric carcinogenesis. Cell Res. 15: 247-54.
6. Gratchev A, Siedow A, Bumke-Vogt C, Hummel M, Foss HD, Hanski ML, Kobalz U, Mann B, Lammert H, Stein H, Riecken EO, Hanski C and Mansmann U (2001) Regulation of the intestinal mucin MUC2 gene expression in vivo: evidence for the role of promoter methylation. Cancer Lett. 168: 71-80.
7. Hanski C, Riede E, Gratchev A, Foss HD, Bohm C, Klussmann E, Hummel M, Mann B, Buhr HJ, Stein H, Kim YS and Riecken EO (1997) MUC2 gene suppression in human colorectal carcinomas and their metastases: in vitro evidence of the modulatory role of DNA methylation. Lab. Invest. 77: 685-95.
8. Herman JG, Graff JR, Myohanen S, Nelkin BD and Baylin SB (1996) Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc. Natl. Acad. Sci. USA 93: 9821-6.
9. Ho JJ, Han SW, Pan PL, Deng G, Kuan SF and Kim YS (2003) Methylation status of promoters and expression of MUC2 and MUC5AC mucins in pancreatic cancer cells. Int. J. Oncol. 22: 273-9.
10. Ho SB, Shekels LL, Toribara NW, Kim YS, Lyftogt C, Cherwitz DL and Niehans GA (1995) Mucin gene expression in normal, preneoplastic, and neoplastic human gastric epithelium. Cancer Res. 55: 2681-90.
11. Hollingsworth MA and Swanson BJ (2004) Mucins in cancer: protection and control of the cell surface. Nat. Rev. Cancer. 4: 45-60.
12. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T and Thun MJ (2008) Cancer statistics, 2008. CA Cancer J. Clin. 58: 71-96.
13. Jones PA and Baylin SB (2002) The fundamental role of epigenetic events in cancer. Nat. Rev. Genet. 3: 415-428.
14. Kang GH, Lee SL, Kim JS and and Jung HY (2003) Profile of aberrant CpG island methylation along multistep gastric carcinogenesis. Lab. Invest. 83: 519-26.
15. Kim DY, Park YK, Joo JK, Ryu SY, Kim YJ, Kim SK and Lee JH (2004) Clinicopathological characteristics of signet ring cell carcinoma of the stomach. ANZ J. Surg. 74: 1060-64.
16. Kononen J, Bubendorf L, Kallioniemi A, Barlund M, Schraml P, Leighton S, Torhorst J, Mihatsch MJ, Sauter G and Kallioniemi OP (1998) Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat. Med. 4: 844-7.
17. Lee HS, Lee HK, Kim HS, Yang HK, Kim YI and Kim WH (2001) MUC1, MUC2, MUC5AC, and MUC6 expression in gastric carcinomas. Cancer 92: 1427-32.
18. Lee HY, Crawley S, Hokari R, Kwon S, Kim YS. (2010) Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR/PKC/Ras/ERK/CREB, PI3K/Akt/IkappaB/NF-kappaB and p38/MSK1/CREB pathways and negative JNK/c-Jun/AP-1 pathway. Int. J. Oncol. 36: 941-953.
19. Leteurtre E, Zerimech F, Piessen G, Wacrenier A, Leroy X, Copin MC, Mariette C, Aubert JP, Porchet N, Buisine MP (2006) Relationships between mucinous gastric carcinoma, MUC2 expression and survival. World J. Gastroenterol. 12: 3324-31.
20. Maehara Y, Sakaguchi Y, Moriguchi S, Orita H, Korenaga D, Kohnoe S and Sugimachi K (1992) Signet ring cell carcinoma of the stomach. Cancer 69: 1645-50.
21. Mesquita P, Peixoto AJ, Seruca R, Hanski C, Almeida R, Silva F, Reis C and David L (2003) Role of site-specific promoter hypomethylation in aberrant MUC2 mucin expression in mucinous gastric carcinomas. Cancer Lett. 189: 129-36.
22. Okudaira K, Kakar S, Cun L, Choi E, Decamillis RW, Miura S, Sleisenger MH, Kim YS, Deng G. (2010) MUC2 gene promoter methylation in mucinous and non-mucinous colorectal cancer tissues. Int. J. Oncol. 36: 765-775.
23. Porchet N and Aubert JP (2004) MUC genes: mucin or not mucin? Med. Sci. (Paris) 20: 569-74.
24. Reis CA, David L, Correa P, Carneiro F, de Bolos C, Gascia E, Mandel U, Clausen H and Sobrinho-Simes M (1999) Intestinal metaplasia of human stomach displays distinct patterns of mucin (MUC1, MUC2, MUC5AC, MUC6) expression. Cancer Res. 59: 1003-7.
25. Senapati S, Sharma P, Bafna S, Roy HK and Batra SK (2008) The MUC gene family: their role in the diagnosis and prognosis of gastric cancer. Histol. Histopathol. 23: 1541-52.
26. Utsunomiya T, Yonezawa S, Sakamoto H, Kitamura H, Hokita S, Aiko T, Tanaka S, Irimura T, Kim YS and Sato E (1998) Expression of MUC1 and MUC2 mucins in gastric carcinomas: its relationship with prognosis of patients. Clin. Cancer. Res. 4: 2605-14.
27. Vauhkonen M, Vauhkonen H and Sipponen P (2006) Pathology and molecular biology of gastric cancer. Best Pract. Res. Clin. Gastroenterol. 20: 651-674.
28. Velcich A, Yang WC, Heyer J, Fragale A, Nicholas C, Viani S, Kucherlapati R, Lipkin M, Yang K and Augenlicht L (2002) Colorectal cancer in mice genetically deficient in the mucin Muc2. Science 295: 1726-9.
29. Wang RQ and Fang DC (2006) Effect of Helicobacter pylori infection on mucin expression in gastric carcinoma and pericancerous tissues. J. Gastroenterol. Hapatol. 21: 425-31.
30. Yamada N, Hamada T, Goto M, Tsutsumida H, Nomoto M and Yonezawa S (2006) MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancer. Int. J. Cancer 119: 1850-57.
31. Yasuda K, Adachi Y, Shiraishi N, Yamaguchi K and Shiromizu A (2001) Pathology and prognosis of mucinous gastric carcinoma. J. Surg. Oncol. 76: 272-7.
32. Yonezawa S, Goto M, Yamada N, Higashi M and Normoto M (2008) Expression profile of MUC1, MUC2, and MUC4 mucins in human neoplasms and their relationship with biological behaviors. Proteomics 8: 3329-41.