Correlation of the immunohistochemical reactivity of mucin peptide cores MUC1 and MUC2 with the histopathological subtype and prognosis of gastric carcinomas

International Journal of Cancer

Volumn 79, Issue 2, 1998, Pages 133-138

  Baldus, Stephan E ^a   Zirbes, Thomas K ^a   Engel, Sabine ^a   Hanisch, Franz Georg ^a   Mönig, Stefan P ^a   Lorenzen, Johann ^a   Glossmann, Jan ^a   Fromm, Susanne ^a   Thiele, Jürgen ^a   Pichlmaier, Heinz ^a   Dienes, Hans P ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CANCER CLASSIFICATION; CANCER GROWTH; CANCER STAGING; FEMALE; FOLLOW UP; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH VESSEL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; SIGNET RING CARCINOMA; STOMACH CARCINOMA; STOMACH PARIETAL CELL;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, MONOCLONAL; CA-15-3 ANTIGEN; FEMALE; GASTRECTOMY; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MUCINS; NEOPLASM STAGING; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RETROSPECTIVE STUDIES; STOMACH NEOPLASMS; SURVIVAL ANALYSIS; TIME FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 0031919583     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19980417)79:2<133::AID-IJC6>3.0.CO;2-U     Document Type: Article

References (21)

1. BARA, J., IMBERTY, A., PÉREZ, S., IMAI, K., YACHI, A. and ORIOL, R., A fucose residue can mask the MUC-1 epitopes in normal and cancerous gastric mucosae. Int. J. Cancer, 54, 607-613 (1993).
2. CARRATO, C., BALAGUE, C., DE BOLÓS, C., GONZALEZ, E., GAMBÚS, G., PLANAS, J., PERINI, J.M., ANDREU, D. and REAL, F.X., Differential apomucin expression in normal and neoplastic human gastrointestinal tissues. Gastroenterology, 107, 160-172 (1994).
3. CHUNG, Y.-S., YAMASHITA, Y., KATO, Y., NAKATA, B., SAWADA, T. and SOWA, M., Prognostic significance of T antigen expression in patients with gastric carcinoma. Cancer, 77, 1768-1773 (1996).
4. DEVINE, P.L., MCGUCKIN, M.A., BIRRELL, G.W., WHITEHEAD, R.H., SACHDEV, G.P., SHIELD, P. and WARD, B.G., Monoclonal antibodies reacting with the MUC2 mucin core protein. Brit. J. Cancer, 67, 1182-1188 (1993).
5. ESAKI, Y., HIRAYAMA, R. and HIROKAWA, K., A comparison of patterns of metastasis in gastric cancer by histologic type and age. Cancer, 65, 2086-2090 (1990).
6. GAMBÚS, G., DE BOLÓS, C., ANDREU, D., FRANC, Í., EGEA, G. and REAL, F.X., Detection of the MUC2 apomucin tandem repeat with a mouse monoclonal antibody. Gastroenterology, 104, 93-102 (1993).
7. GENDLER, S., TAYLOR-PAPADIMITRIOU, J., DUHIG, T., ROTHBARD, J. and BURCHELL, J., A highly immunogenic region of a human polymorphic epithelial mucin expressed by carcinomas is made up of tandem repeats. J. biol. Chem., 263, 12820-12823 (1988).
8. HO, S.B., NIEHANS, G.A., LYFTOGT, C., YAN, P.S., CHERWITZ, D.L., GUM, E.T., DAHIYA, R. and KIM, Y.S., Heterogeneity of mucin gene expression in normal and neoplastic tissues. Cancer Res., 53, 641-651 (1993).
9. HO, S.B., SHEKELS, L.L., TORIBARA, N.W., KIM, Y.S., LYFTOGT, C., CHERWITZ, D.L. and NIEHANS, G.A., Mucin gene expression in normal, preneoplastic, and neoplastic human gastric epithelium. Cancer Res., 55, 2681-2690 (1995).
10. KAKEJI, Y., MAEHARA, Y., MORITA, M., MATSUKUMA, A., FURUSAWA, M., TAKAHASHI, I., KUSUMOTO, T., OHNO, S. and SUGIMACHI, K., Correlation between sialyl Tn antigen and lymphatic metastasis in patients with Borrmann type IV gastric carcinoma. Brit. J. Cancer, 71, 191-195 (1995).
11. 4-mediated adhesion to laminin and kalinin and E-cadherin-mediated cell-cell-interaction. J. Cell Biol., 127, 2071-2080 (1994).
12. MÜLLER, S., GOLETZ, S., PACKER, N., GOOLEY, A., LAWSON, A.M., HANISCH, F.-G., Localization of O-glycosylation sites on glycopeptide fragments from lactation-associated MUC1. J. biol. Chem., 212, 24780-24793 (1997).
13. a: a new functional prognostic factor in gastric cancer. J. clin. Oncol., 15, 816-825 (1997).
14. RIBEIRO, M.M., SARMENTO, J.A., SIMGES, M.A.S. and BASTOS, J., Prognostic significance of Laurén and Ming classification and other prognostic parameters in gastric carcinomas. Cancer, 47, 780-784 (1981).
15. SOJAR, H.T. and BAHL, O.P., A chemical method for the deglycosylation of proteins. Arch. Biochem. Biophys., 259, 52-57 (1987).
16. STADIE, T.R.E., CHAI, W., LAWSON, A.M., BYFIELD, P.G.H. and HANISCH, F.-G., Studies on the order and site specificity of GalNAc transfer to MUC1 tandem repeats by UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase from milk or mammary carcinoma cells. Europ. J. Biochem., 229, 140-147 (1995).
17. VICTORZON, M., NORDLING, S., NILSSON, O., ROBERTS, P.J. and HAGLUND, C., Sialyl Tn antigen is an independent predictor of outcome in patients with gastric cancer. Int. J. Cancer, 65, 295-300 (1996).
18. WALKER, M.M., SMOLKA, A., WALLER, J.M. and EVANS, D.J., Identification of parietal cells in gastric body mucosa with HMFG-2 monoclonal antibody. J. clin. Pathol., 48, 832-834 (1995).
19. WERTHER, J.L., RIVERA-MACMURRAY, S., BRUCKNER, H., TATEMATSU, M. and ITZKOWITZ, S.H., Mucin-associated sialosyl-Tn antigen expression in gastric cancer correlates with an adverse outcome. Brit. J. Cancer, 69, 613-616 (1994).
20. WESSELING, J., VALK, S.W., VOS, H.L., SONNENBERG, A. and HILKENS, J., Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components. J. Cell. Biol., 129, 255-265 (1995).
21. XING, P.-X., APOSTOPOULOS, V., PRENZOSKA, J., DEVINE, P.L. and MCKENZIE, I.F.C., Peptide binding sites recognized by anti-mucin (MUC 2) monoclonal antibodies. Scand. J. Immunol., 38, 591-592 (1993).