Discovery of heterocyclic ureas as a new class of raf kinase inhibitors: Identification of a second generation lead by a combinatorial chemistry approach

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 20, 2001, Pages 2775-2778

  Smith, Roger A ^a   Barbosa, James ^a   Blum, Cheri L ^b   Bobko, Mark A ^a   Caringal, Yolanda V ^a   Dally, Robert ^a   Johnson, Jeffrey S ^a   Katz, Michael E ^a   Kennure, Nancy ^a   Kingery Wood, Jill ^a   Lee, Wendy ^a   Lowinger, Timothy B ^a   Lyons, John ^b   Marsh, Vivienne ^b   Rogers, Daniel H ^b   Swartz, Stephen ^a   Walling, Tracy ^a   Wild, Hanno ^a  

^a BAYER CORPORATION   (United States)

^b ONYX PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOTRANSFERASE; PHOSPHOTRANSFERASE INHIBITOR; RAF KINASE INHIBITOR; RAF PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ARTICLE; COMBINATORIAL CHEMISTRY; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; IC 50; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

PROTO-ONCOGENE PROTEINS C-RAF; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 0035935203     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00571-6     Document Type: Article

References (19)