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Volumn 14, Issue 3, 2014, Pages 559-570

Identification of the protopanaxatriol synthase gene CYP6H for ginsenoside biosynthesis in Panax quinquefolius

Author keywords

CYP6H; Ginsenoside; Overexpression; Panax quinquefolius; Protopanaxatriol synthase; RNA interferences

Indexed keywords

GINSENOSIDE; PROTOPANAXATRIOL SYNTHASE; SYNTHETASE; UNCLASSIFIED DRUG; PROTOPANAXADIOL; SAPOGENIN; UNSPECIFIC MONOOXYGENASE; VEGETABLE PROTEIN;

EID: 84906348406     PISSN: 1438793X     EISSN: 14387948     Source Type: Journal    
DOI: 10.1007/s10142-014-0386-z     Document Type: Article
Times cited : (24)

References (31)
  • 1
    • 0042303946 scopus 로고    scopus 로고
    • Phytochemistry of wild populations of Panax quinquefolius L. (North American ginseng)
    • Assinewe VA, Baum BR, Gagnon D, Arnason JT (2003) Phytochemistry of wild populations of Panax quinquefolius L. (North American ginseng). J Agric Food Chem 51:4549-4553
    • (2003) J Agric Food Chem , vol.51 , pp. 4549-4553
    • Assinewe, V.A.1    Baum, B.R.2    Gagnon, D.3    Arnason, J.T.4
  • 2
    • 0344549853 scopus 로고    scopus 로고
    • Ginseng pharmacology: Multiple constituents and multiple actions
    • DOI 10.1016/S0006-2952(99)00212-9, PII S0006295299002129
    • Attele AS, Wu JA, Yuan CS (1999) Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol 58:1685-1693 (Pubitemid 29505408)
    • (1999) Biochemical Pharmacology , vol.58 , Issue.11 , pp. 1685-1693
    • Attele, A.S.1    Wu, J.A.2    Yuan, C.-S.3
  • 4
    • 0033787978 scopus 로고    scopus 로고
    • Medicinal plants and phytomedicines. Linking plant biochemistry and physiology to human health
    • Briskin DP (2000) Medicinal plants and phytomedicines. Linking plant biochemistry and physiology to human health. Plant Physiol 124:507-514
    • (2000) Plant Physiol , vol.124 , pp. 507-514
    • Briskin, D.P.1
  • 6
    • 84886486790 scopus 로고    scopus 로고
    • Metabolic engineering of Saccharomyces cerevisiae for production of ginsenosides
    • Dai Z, Liu Y, Zhang X, Shi M, Wang B, Wang D et al (2013) Metabolic engineering of Saccharomyces cerevisiae for production of ginsenosides. Metab Eng 20:146-156
    • (2013) Metab Eng , vol.20 , pp. 146-156
    • Dai, Z.1    Liu, Y.2    Zhang, X.3    Shi, M.4    Wang, B.5    Wang, D.6
  • 7
    • 0041336976 scopus 로고    scopus 로고
    • Anti-hyperglycemic effects of ginseng: Comparison between root and berry
    • DOI 10.1078/094471103322331908
    • Dey L, Xie JT, Wang A, Wu J, Maleckar SA, Yuan CS (2003) Antihyperglycemic effects of ginseng: comparison between root and berry. Phytomedicine 10:600-605 (Pubitemid 37092688)
    • (2003) Phytomedicine , vol.10 , Issue.6-7 , pp. 600-605
    • Dey, L.1    Xie, J.T.2    Wang, A.3    Wu, J.4    Maleckar, S.A.5    Yuan, C.-S.6
  • 8
    • 0026562884 scopus 로고
    • Improved method for high efficiency transformation of intact yeast cells
    • Gietz D, St Jean A, Woods RA, Schiestl RH (1992) Improved method for high efficiency transformation of intact yeast cells. Nucleic Acids Res 20:1425
    • (1992) Nucleic Acids Res , vol.20 , pp. 1425
    • Gietz, D.1    St Jean, A.2    Woods, R.A.3    Schiestl, R.H.4
  • 9
    • 33845712221 scopus 로고    scopus 로고
    • Expression and RNA interference-induced silencing of the dammarenediol synthase gene in Panax ginseng
    • DOI 10.1093/pcp/pcl032
    • Han JY, Kwon YS, Yang DC, Jung YR, Choi YE (2006) Expression and RNA interference-induced silencing of the dammarenediol synthase gene in Panax ginseng. Plant Cell Physiol 47:1653-1662 (Pubitemid 44968260)
    • (2006) Plant and Cell Physiology , vol.47 , Issue.12 , pp. 1653-1662
    • Han, J.Y.1    Kwon, Y.S.2    Yang, D.C.3    Jung, Y.R.4    Choi, Y.E.5
  • 10
    • 72149121133 scopus 로고    scopus 로고
    • Regulation of ginsenoside and phytosterol biosynthesis by RNA interferences of squalene epoxidase gene in Panax ginseng
    • Han JY, In JG, Kwon YS, Choi YE (2010) Regulation of ginsenoside and phytosterol biosynthesis by RNA interferences of squalene epoxidase gene in Panax ginseng. Phytochemistry 71(1):36-46
    • (2010) Phytochemistry , vol.71 , Issue.1 , pp. 36-46
    • Han, J.Y.1    In, J.G.2    Kwon, Y.S.3    Choi, Y.E.4
  • 11
    • 83255165496 scopus 로고    scopus 로고
    • The Cyt P450 enzyme CYP716A47 c a t a lyzes the formation of protopanaxadiol from dammarenediol-II during ginsenoside biosynthesis in Panax ginseng
    • Han JY, Kim HJ, Kwon YS, Choi YE (2011) The Cyt P450 enzyme CYP716A47 c a t a lyzes the formation of protopanaxadiol from dammarenediol-II during ginsenoside biosynthesis in Panax ginseng. Plant Cell Physiol 52:2062-2073
    • (2011) Plant Cell Physiol , vol.52 , pp. 2062-2073
    • Han, J.Y.1    Kim, H.J.2    Kwon, Y.S.3    Choi, Y.E.4
  • 12
    • 84866386264 scopus 로고    scopus 로고
    • Cytochrome P450 CYP716A53v2 catalyzes the formation of protopanaxatriol from protopanaxadiol during ginsenoside biosynthesis in Panax ginseng
    • Han JY, Hwang HS, Choi SW, Kim HJ, Choi YE (2012) Cytochrome P450 CYP716A53v2 catalyzes the formation of protopanaxatriol from protopanaxadiol during ginsenoside biosynthesis in Panax ginseng. Plant Cell Physiol 53(9):1535-1545
    • (2012) Plant Cell Physiol , vol.53 , Issue.9 , pp. 1535-1545
    • Han, J.Y.1    Hwang, H.S.2    Choi, S.W.3    Kim, H.J.4    Choi, Y.E.5
  • 13
    • 84886995125 scopus 로고    scopus 로고
    • Identification of 20 (S)-protopanaxatriol metabolites in rats by ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry and nuclear magnetic resonance spectroscopy
    • He C, Zhou D, Li J, Han H, Ji G, Yang L, Wang Z (2014) Identification of 20 (S)-protopanaxatriol metabolites in rats by ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry and nuclear magnetic resonance spectroscopy. J Pharm Biomed Anal 88:497-508
    • (2014) J Pharm Biomed Anal , vol.88 , pp. 497-508
    • He, C.1    Zhou, D.2    Li, J.3    Han, H.4    Ji, G.5    Yang, L.6    Wang, Z.7
  • 16
    • 67349125738 scopus 로고    scopus 로고
    • Upregulation of ginsenoside and gene expression related to triterpene biosynthesis in ginseng hairy root cultures elicited by methyl jasmonate
    • Kim OT, Bang KW, Kim YC, Hyun DY, Kim MY, Cha SW (2009) Upregulation of ginsenoside and gene expression related to triterpene biosynthesis in ginseng hairy root cultures elicited by methyl jasmonate. Plant Cell Tissue Organ Cult 98:25-33
    • (2009) Plant Cell Tissue Organ Cult , vol.98 , pp. 25-33
    • Kim, O.T.1    Bang, K.W.2    Kim, Y.C.3    Hyun, D.Y.4    Kim, M.Y.5    Cha, S.W.6
  • 17
    • 34547406188 scopus 로고    scopus 로고
    • Parameters affecting the extraction of ginsenosides from the adventitious roots of ginseng (Panax ginseng C.A. Meyer)
    • DOI 10.1016/j.seppur.2007.06.014, PII S138358660700295X
    • Kima SJ, Murthy HN, Hahn EJ, Lee HL, Paek KY (2007) Parameters affecting the extraction of ginsenosides from the adventitious roots of ginseng (Panax ginseng C.A. Meyer). Sep Purif Technol 56:401-406 (Pubitemid 47176490)
    • (2007) Separation and Purification Technology , vol.56 , Issue.3 , pp. 401-406
    • Kim, S.-J.1    Murthy, H.N.2    Hahn, E.-J.3    Lee, H.L.4    Paek, K.-Y.5
  • 18
    • 0029886899 scopus 로고    scopus 로고
    • ERG1, encoding squalene epoxidase, is located on the right arm of chromosome VII of Saccharomyces cerevisiae
    • DOI 10.1002/(SICI)1097-0061(199605)12:6<609::AID-Y
    • Landl KM, Klösch B, Turnowsky F (1996) ERG1, encoding Squalene epoxidase, is located on the right arm of chromosome VII of Saccharomyces cerevisiae. Yeast 12:609-613 (Pubitemid 26176934)
    • (1996) Yeast , vol.12 , Issue.6 , pp. 609-613
    • Landl, K.M.1    Klosch, B.2    Turnowsky, F.3
  • 19
    • 4644290998 scopus 로고    scopus 로고
    • Enhanced triterpene and phytosterol biosynthesis in Panax ginseng overexpressing squalene synthase gene
    • Lee MH, Jeong JH, Seo JW, Shin CG, Kim YS, In JG et al (2004) Enhanced triterpene and phytosterol biosynthesis in Panax ginseng overexpressing squalene synthase gene. Plant Cell Physiol 45:976-984
    • (2004) Plant Cell Physiol , vol.45 , pp. 976-984
    • Lee, M.H.1    Jeong, J.H.2    Seo, J.W.3    Shin, C.G.4    Kim, Y.S.5    In, J.G.6
  • 20
    • 45149098195 scopus 로고    scopus 로고
    • Progress in understanding of ginsenoside biosynthesis
    • DOI 10.1111/j.1438-8677.2008.00064.x
    • Liang Y, Zhao S (2008) Progress in understanding of ginsenoside biosynthesis. Plant Biol (Stuttg) 10:415-421 (Pubitemid 351832386)
    • (2008) Plant Biology , vol.10 , Issue.4 , pp. 415-421
    • Liang, Y.1    Zhao, S.2
  • 21
    • 84255163349 scopus 로고    scopus 로고
    • Analysis of the transcriptome of Panax notoginseng root uncovers putative triterpene saponin-biosynthetic genes and genetic markers
    • Luo H, Sun C, Sun Y, Wu Q, Li Y, Song J et al (2011) Analysis of the transcriptome of Panax notoginseng root uncovers putative triterpene saponin-biosynthetic genes and genetic markers. BMC Genomics 12(Suppl 5):S5
    • (2011) BMC Genomics , vol.12 , Issue.SUPPL. 5
    • Luo, H.1    Sun, C.2    Sun, Y.3    Wu, Q.4    Li, Y.5    Song, J.6
  • 22
    • 79954627696 scopus 로고    scopus 로고
    • Ginsenosides from American ginseng: Chemical and pharmacological diversity
    • Qi LW, Wang CZ, Yuan CS (2011) Ginsenosides from American ginseng: chemical and pharmacological diversity. Phytochemistry 72:689-699
    • (2011) Phytochemistry , vol.72 , pp. 689-699
    • Qi, L.W.1    Wang, C.Z.2    Yuan, C.S.3
  • 23
    • 0028847493 scopus 로고
    • Simultaneous analysis of saponins in ginseng radix by high performance liquid chromatography
    • Samukawa K, Yamashita H, Matsuda H, Kubo M (1995) Simultaneous analysis of saponins in ginseng radix by high performance liquid chromatography. Chem Pharm Bull 43:137-141
    • (1995) Chem Pharm Bull , vol.43 , pp. 137-141
    • Samukawa, K.1    Yamashita, H.2    Matsuda, H.3    Kubo, M.4
  • 25
    • 84887295821 scopus 로고    scopus 로고
    • Regulation and differential expression of protopanaxadiol synthase in Asian and American ginseng ginsenoside biosynthesis by RNA interferences
    • Sun Y, Zhao SJ, Liang YL et al (2013) Regulation and differential expression of protopanaxadiol synthase in Asian and American ginseng ginsenoside biosynthesis by RNA interferences. Plant Growth Regul 71(3):207-217
    • (2013) Plant Growth Regul , vol.71 , Issue.3 , pp. 207-217
    • Sun, Y.1    Zhao, S.J.2    Liang, Y.L.3
  • 26
    • 33748809553 scopus 로고    scopus 로고
    • Dammarenediol-II synthase, the first dedicated enzyme for ginsenoside biosynthesis, in Panax ginseng
    • DOI 10.1016/j.febslet.2006.08.044, PII S0014579306010209
    • Tansakul P, Shibuya M, Kushiro T, Ebizuka Y (2006) Dammarenediol-II synthase, the first dedicated enzyme for ginsenoside biosynthesis, in Panax ginseng. FEBS Lett 580:5143-5149 (Pubitemid 44415784)
    • (2006) FEBS Letters , vol.580 , Issue.22 , pp. 5143-5149
    • Tansakul, P.1    Shibuya, M.2    Kushiro, T.3    Ebizuka, Y.4
  • 27
    • 34548528654 scopus 로고    scopus 로고
    • Expression of the gene for sterol-biosynthesis enzyme squalene epoxidase in parenchyma cells of the oil plant, Euphorbia tirucalli
    • DOI 10.1007/s00425-007-0557-4
    • Uchida H, Sugiyama R, Nakayachi O, Takemura M, Ohyama K (2007) Expression of the gene for sterol-biosynthesis enzyme squalene epoxidase in parenchyma cells of the oil plant, Euphorbia tirucalli. Planta 226:1109-1115 (Pubitemid 47383794)
    • (2007) Planta , vol.226 , Issue.5 , pp. 1109-1115
    • Uchida, H.1    Sugiyama, R.2    Nakayachi, O.3    Takemura, M.4    Ohyama, K.5
  • 28
    • 0032830802 scopus 로고    scopus 로고
    • The efficacy of ginseng. A systematic review of randomised clinical trials
    • DOI 10.1007/s002280050674
    • Vogler BK, Pittler MH, Ernst E (1999) The efficacy of ginseng. A systematic review of randomised clinical trials. Eur J Clin Pharmacol 55:567-575 (Pubitemid 29489202)
    • (1999) European Journal of Clinical Pharmacology , vol.55 , Issue.8 , pp. 567-575
    • Vogler, B.K.1    Pittler, M.H.2    Ernst, E.3
  • 29
    • 77955428907 scopus 로고    scopus 로고
    • Production of plant bioactive triterpenoid saponins: Elicitation strategies and target genes to improve yields
    • Yendo ACA, de Costa F, Gosmann G, Fett-Neto AG (2010) Production of plant bioactive triterpenoid saponins: elicitation strategies and target genes to improve yields. Mol Biotechnol 46:94-104
    • (2010) Mol Biotechnol , vol.46 , pp. 94-104
    • Yendo, A.C.A.1    De Costa, F.2    Gosmann, G.3    Fett-Neto, A.G.4
  • 30
    • 0036723052 scopus 로고    scopus 로고
    • Jasmonic acid improves ginsenoside accumulation in adventitious root culture of Panax ginseng C.A. Meyer
    • Yu KW, Gao W, Hahn EJ, Paek KY (2002) Jasmonic acid improves ginsenoside accumulation in adventitious root culture of Panax ginseng C.A. Meyer. Biochem Eng J 11:211-215
    • (2002) Biochem Eng J , vol.11 , pp. 211-215
    • Yu, K.W.1    Gao, W.2    Hahn, E.J.3    Paek, K.Y.4
  • 31
    • 48449104743 scopus 로고    scopus 로고
    • Protopanaxadiol 6-hydroxylase and its role in regulating the ginsenoside heterogeneity in Panax notoginseng cells
    • Yue CJ, Zhou X, Zhong JJ (2008) Protopanaxadiol 6-hydroxylase and its role in regulating the ginsenoside heterogeneity in Panax notoginseng cells. Biotechnol Bioeng 100(5):933-940
    • (2008) Biotechnol Bioeng , vol.100 , Issue.5 , pp. 933-940
    • Yue, C.J.1    Zhou, X.2    Zhong, J.J.3


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