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Volumn 10, Issue 4, 2008, Pages 415-421

Progress in understanding of ginsenoside biosynthesis

Author keywords

Ginseng; Ginsenosides biosythesis; Triterpene saponins

Indexed keywords

GINSENOSIDE;

EID: 45149098195     PISSN: 14358603     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1438-8677.2008.00064.x     Document Type: Review
Times cited : (108)

References (52)
  • 1
    • 12044254693 scopus 로고
    • Enzymatic cyclization of squalene and oxidosqualene to sterols and triterpenes
    • Abe I., Rohmer M., Prestwich G.D. (1993) Enzymatic cyclization of squalene and oxidosqualene to sterols and triterpenes. Chemical Reviews, 93, 2189 2206.
    • (1993) Chemical Reviews , vol.93 , pp. 2189-2206
    • Abe, I.1    Rohmer, M.2    Prestwich, G.D.3
  • 2
    • 33749060647 scopus 로고    scopus 로고
    • Copper-induced changes in the growth, oxidative metabolism, and saponin production in suspension culture roots of Panax ginseng in bioreactors
    • Ali M.B., Hahn E.J., Paek K.Y. (2006a) Copper-induced changes in the growth, oxidative metabolism, and saponin production in suspension culture roots of Panax ginseng in bioreactors. Plant Cell Reports, 25, 1122 1132.
    • (2006) Plant Cell Reports , vol.25 , pp. 1122-1132
    • Ali, M.B.1    Hahn, E.J.2    Paek, K.Y.3
  • 3
    • 33646868795 scopus 로고    scopus 로고
    • Methyl jasmonate and salicylic acid elicitation induces ginsenoside accumulation, enzymatic and non-enzymatic antioxidants in suspension culture Panax ginseng roots in bioreactors
    • Ali M.B., Yu K.W., Hahn E.J., Paek K.Y. (2006b) Methyl jasmonate and salicylic acid elicitation induces ginsenoside accumulation, enzymatic and non-enzymatic antioxidants in suspension culture Panax ginseng roots in bioreactors. Plant Cell Reports, 25, 613 620.
    • (2006) Plant Cell Reports , vol.25 , pp. 613-620
    • Ali, M.B.1    Yu, K.W.2    Hahn, E.J.3    Paek, K.Y.4
  • 4
    • 12844289137 scopus 로고    scopus 로고
    • Analysis of transcripts in methyl jasmonate-treated ginseng hairy roots to identify genes involved in the biosynthesis of ginsenosides and other secondary metabolites
    • Choi D.W., Jung J., Ha Y.I., Park H.W., In D.S., Chung H.J., Liu J.R. (2005) Analysis of transcripts in methyl jasmonate-treated ginseng hairy roots to identify genes involved in the biosynthesis of ginsenosides and other secondary metabolites. Plant Cell Reports, 23, 557 566.
    • (2005) Plant Cell Reports , vol.23 , pp. 557-566
    • Choi, D.W.1    Jung, J.2    Ha, Y.I.3    Park, H.W.4    In, D.S.5    Chung, H.J.6    Liu, J.R.7
  • 8
    • 33646414810 scopus 로고    scopus 로고
    • Ginsenoside Rg8, a new dammarane-type triterpenoid saponin from roots of Panax quinquefolium
    • Dou D., Li W., Guo N., Fu R., Pei Y., Koike K., Nikaido T. (2006) Ginsenoside Rg8, a new dammarane-type triterpenoid saponin from roots of Panax quinquefolium. Chemical & Pharmaceutical Bulletin, 54, 751 753.
    • (2006) Chemical & Pharmaceutical Bulletin , vol.54 , pp. 751-753
    • Dou, D.1    Li, W.2    Guo, N.3    Fu, R.4    Pei, Y.5    Koike, K.6    Nikaido, T.7
  • 10
    • 33646151860 scopus 로고    scopus 로고
    • Cloning and characterization of a lupeol synthase involved in the synthesis of epicuticular wax crystals on stem and hypocotyl surfaces of Ricinus communis
    • Guhling O., Hobl B., Yeats T., Jetter R. (2006) Cloning and characterization of a lupeol synthase involved in the synthesis of epicuticular wax crystals on stem and hypocotyl surfaces of Ricinus communis. Archives of Biochemistry and Biophysics, 448, 60 72.
    • (2006) Archives of Biochemistry and Biophysics , vol.448 , pp. 60-72
    • Guhling, O.1    Hobl, B.2    Yeats, T.3    Jetter, R.4
  • 11
    • 12844282432 scopus 로고    scopus 로고
    • Biosynthesis of mono- and sesquiterpenes in carrot roots and leaves (Daucus carota L.): Metabolic cross talk of cytosolic mevalonate and plastidial methylerythritol phosphate pathways
    • Hampel D., Mosandl A., Wust M. (2005) Biosynthesis of mono- and sesquiterpenes in carrot roots and leaves (Daucus carota L.): metabolic cross talk of cytosolic mevalonate and plastidial methylerythritol phosphate pathways. Phytochemistry, 66, 305 311.
    • (2005) Phytochemistry , vol.66 , pp. 305-311
    • Hampel, D.1    Mosandl, A.2    Wust, M.3
  • 12
    • 33845712221 scopus 로고    scopus 로고
    • Expression and RNA interference-induced silencing of the dammarenediol synthase gene in Panax ginseng
    • Han J.Y., Kwon Y.S., Yang D.C., Jung Y.R., Choi Y.E. (2006) Expression and RNA interference-induced silencing of the dammarenediol synthase gene in Panax ginseng. Plant & Cell Physiology, 47, 1653 1662.
    • (2006) Plant & Cell Physiology , vol.47 , pp. 1653-1662
    • Han, J.Y.1    Kwon, Y.S.2    Yang, D.C.3    Jung, Y.R.4    Choi, Y.E.5
  • 14
    • 4644356962 scopus 로고    scopus 로고
    • Cancer prevention and therapeutics: Panax ginseng
    • Helms S. (2004) Cancer prevention and therapeutics: Panax ginseng. Alternative Medicine Review, 9, 259 274.
    • (2004) Alternative Medicine Review , vol.9 , pp. 259-274
    • Helms, S.1
  • 16
    • 0032399269 scopus 로고    scopus 로고
    • Cloning and characterization of the Arabidopsis thaliana lupeol synthase gene
    • Herrera J.B., Bartel B., Wilson W.K., Matsuda S.P. (1998) Cloning and characterization of the Arabidopsis thaliana lupeol synthase gene. Phytochemistry, 49, 1905 1911.
    • (1998) Phytochemistry , vol.49 , pp. 1905-1911
    • Herrera, J.B.1    Bartel, B.2    Wilson, W.K.3    Matsuda, S.P.4
  • 17
    • 0036714123 scopus 로고    scopus 로고
    • Isoprenoid biosynthesis in higher plants and in Escherichia coli: On the branching in the methylerythritol phosphate pathway and the independent biosynthesis of isopentenyl diphosphate and dimethylallyl diphosphate
    • Hoeffler J.F., Hemmerlin A., Grosdemange-Billiard C., Bach T.J., Rohmer M. (2002) Isoprenoid biosynthesis in higher plants and in Escherichia coli: on the branching in the methylerythritol phosphate pathway and the independent biosynthesis of isopentenyl diphosphate and dimethylallyl diphosphate. The Biochemical Journal, 366, 573 583.
    • (2002) The Biochemical Journal , vol.366 , pp. 573-583
    • Hoeffler, J.F.1    Hemmerlin, A.2    Grosdemange-Billiard, C.3    Bach, T.J.4    Rohmer, M.5
  • 22
    • 12444277612 scopus 로고    scopus 로고
    • Adventitious root growth and ginsenoside accumulation in Panax ginseng cultures as affected by methyl jasmonate
    • Kim Y.S., Hahn E.J., Murthy H.N., Paek K.Y. (2004) Adventitious root growth and ginsenoside accumulation in Panax ginseng cultures as affected by methyl jasmonate. Biotechnology Letters, 26, 1619 1622.
    • (2004) Biotechnology Letters , vol.26 , pp. 1619-1622
    • Kim, Y.S.1    Hahn, E.J.2    Murthy, H.N.3    Paek, K.Y.4
  • 23
    • 33646863676 scopus 로고    scopus 로고
    • Comparative analysis of expressed sequence tags (ESTs) of ginseng leaf
    • Kim M.K., Lee B.S., In J.G., Sun H., Yoon J.H., Yang D.C. (2006) Comparative analysis of expressed sequence tags (ESTs) of ginseng leaf. Plant Cell Reports, 25, 599 606.
    • (2006) Plant Cell Reports , vol.25 , pp. 599-606
    • Kim, M.K.1    Lee, B.S.2    In, J.G.3    Sun, H.4    Yoon, J.H.5    Yang, D.C.6
  • 24
    • 33947364766 scopus 로고    scopus 로고
    • American ginseng (Panax quinquefolius L.) extract alters mitogen-activated protein kinase cell signaling and inhibits proliferation of MCF-7 cells
    • King M.L., Murphy L.L. (2007) American ginseng (Panax quinquefolius L.) extract alters mitogen-activated protein kinase cell signaling and inhibits proliferation of MCF-7 cells. Journal of Experimental Therapeutics & Oncology, 6, 147 155.
    • (2007) Journal of Experimental Therapeutics & Oncology , vol.6 , pp. 147-155
    • King, M.L.1    Murphy, L.L.2
  • 25
    • 0030964465 scopus 로고    scopus 로고
    • In vitro conversion of 2,3-oxidosqualene into dammarenediol by Panax ginseng microsomes
    • Kushiro T., Ohno Y., Shibuya M., Ebizuka Y. (1997) In vitro conversion of 2,3-oxidosqualene into dammarenediol by Panax ginseng microsomes. Biological & Pharmaceutical Bulletin, 20, 292 294.
    • (1997) Biological & Pharmaceutical Bulletin , vol.20 , pp. 292-294
    • Kushiro, T.1    Ohno, Y.2    Shibuya, M.3    Ebizuka, Y.4
  • 26
    • 0032529028 scopus 로고    scopus 로고
    • Beta-amyrin synthase - Cloning of oxidosqualene cyclase that catalyzes the formation of the most popular triterpene among higher plants
    • Kushiro T., Shibuya M., Ebizuka Y. (1998) Beta-amyrin synthase - cloning of oxidosqualene cyclase that catalyzes the formation of the most popular triterpene among higher plants. European Journal of Biochemistry, 256, 238 244.
    • (1998) European Journal of Biochemistry , vol.256 , pp. 238-244
    • Kushiro, T.1    Shibuya, M.2    Ebizuka, Y.3
  • 28
    • 24344440764 scopus 로고    scopus 로고
    • Studies on the influence of fungal elicitor on hairy root of Panax ginseng biosynthesis, ginseng saponin and biomass
    • Liu J., Ding J.Y., Zhou Q.Y., He L., Wang Z.T. (2004) Studies on the influence of fungal elicitor on hairy root of Panax ginseng biosynthesis, ginseng saponin and biomass. China Journal of Chinese Materia Medica, 29, 302 305.
    • (2004) China Journal of Chinese Materia Medica , vol.29 , pp. 302-305
    • Liu, J.1    Ding, J.Y.2    Zhou, Q.Y.3    He, L.4    Wang, Z.T.5
  • 29
  • 30
    • 0033000090 scopus 로고    scopus 로고
    • Comparison of qualitative and quantitative in vitro ginsenoside production in callus cultures of three Panax species
    • Mathur A., Mathur A.K., Pal M., Uniyal G.C. (1999) Comparison of qualitative and quantitative in vitro ginsenoside production in callus cultures of three Panax species. Planta Medica, 65, 484 486.
    • (1999) Planta Medica , vol.65 , pp. 484-486
    • Mathur, A.1    Mathur, A.K.2    Pal, M.3    Uniyal, G.C.4
  • 32
    • 0037615212 scopus 로고    scopus 로고
    • Growth and ginsenoside production in hairy root cultures of Panax ginseng using a novel bioreactor
    • Palazon J., Mallol A., Eibl R., Lettenbauer C., Cusido R.M., Pinol M.T. (2003) Growth and ginsenoside production in hairy root cultures of Panax ginseng using a novel bioreactor. Planta Medica, 69, 344 349.
    • (2003) Planta Medica , vol.69 , pp. 344-349
    • Palazon, J.1    Mallol, A.2    Eibl, R.3    Lettenbauer, C.4    Cusido, R.M.5    Pinol, M.T.6
  • 35
    • 0031990119 scopus 로고    scopus 로고
    • A new alternative non-mevalonate pathway for isoprenoid biosynthesis in eubacteria and plants
    • Paseshnichenko V.A. (1998) A new alternative non-mevalonate pathway for isoprenoid biosynthesis in eubacteria and plants. Biochemistry, 63, 139 148.
    • (1998) Biochemistry , vol.63 , pp. 139-148
    • Paseshnichenko, V.A.1
  • 37
    • 0036851226 scopus 로고    scopus 로고
    • Elucidation of the methylerythritol phosphate pathway for isoprenoid biosynthesis in bacteria and plastids. a metabolic milestone achieved through genomics
    • Rodriguez-Concepcion M., Boronat A. (2002) Elucidation of the methylerythritol phosphate pathway for isoprenoid biosynthesis in bacteria and plastids. A metabolic milestone achieved through genomics. Plant Physiology, 130, 1079 1089.
    • (2002) Plant Physiology , vol.130 , pp. 1079-1089
    • Rodriguez-Concepcion, M.1    Boronat, A.2
  • 39
    • 33344464402 scopus 로고    scopus 로고
    • Isoprenoid biosynthesis in plant chloroplasts via the MEP pathway: Direct thylakoid/ferredoxin-dependent photoreduction of GcpE/IspG
    • Seemann M., Tse Sum Bui B., Wolff M., Miginiac-Maslow M., Rohmer M. (2006) Isoprenoid biosynthesis in plant chloroplasts via the MEP pathway: direct thylakoid/ferredoxin-dependent photoreduction of GcpE/IspG. FEBS Letters, 580, 1547 1552.
    • (2006) FEBS Letters , vol.580 , pp. 1547-1552
    • Seemann, M.1    Tse Sum Bui, B.2    Wolff, M.3    Miginiac-Maslow, M.4    Rohmer, M.5
  • 40
    • 17444400413 scopus 로고    scopus 로고
    • Overexpression of squalene synthase in Eleutherococcus senticosus increases phytosterol and triterpene accumulation
    • Seo J.W., Jeong J.H., Shin C.G., Lo S.C., Han S.S., Yu K.W., Harada E., Han J.Y., Choi Y.E. (2005) Overexpression of squalene synthase in Eleutherococcus senticosus increases phytosterol and triterpene accumulation. Phytochemistry, 66, 869 877.
    • (2005) Phytochemistry , vol.66 , pp. 869-877
    • Seo, J.W.1    Jeong, J.H.2    Shin, C.G.3    Lo, S.C.4    Han, S.S.5    Yu, K.W.6    Harada, E.7    Han, J.Y.8    Choi, Y.E.9
  • 42
    • 0034075605 scopus 로고    scopus 로고
    • The cancer-preventive potential of Panax ginseng: A review of human and experimental evidence
    • Shin H.R., Kim J.Y., Yun T.K., Morgan G., Vainio H. (2000) The cancer-preventive potential of Panax ginseng: a review of human and experimental evidence. Cancer Causes and Control, 11, 565 576.
    • (2000) Cancer Causes and Control , vol.11 , pp. 565-576
    • Shin, H.R.1    Kim, J.Y.2    Yun, T.K.3    Morgan, G.4    Vainio, H.5
  • 44
    • 33748809553 scopus 로고    scopus 로고
    • Dammarenediol-II synthase, the first dedicated enzyme for ginsenoside biosynthesis, in Panax ginseng
    • Tansakul P., Shibuya M., Kushiro T., Ebizuka Y. (2006) Dammarenediol-II synthase, the first dedicated enzyme for ginsenoside biosynthesis, in Panax ginseng. FEBS Letters, 580, 5143 5149.
    • (2006) FEBS Letters , vol.580 , pp. 5143-5149
    • Tansakul, P.1    Shibuya, M.2    Kushiro, T.3    Ebizuka, Y.4
  • 45
    • 17844403288 scopus 로고    scopus 로고
    • Methyl jasmonate elicitation enhanced synthesis of ginsenoside by cell suspension cultures of Panax ginseng in 5-l balloon type bubble bioreactors
    • Thanh N.T., Murthy H.N., Yu K.W., Hahn E.J., Paek K.Y. (2005) Methyl jasmonate elicitation enhanced synthesis of ginsenoside by cell suspension cultures of Panax ginseng in 5-l balloon type bubble bioreactors. Applied Microbiology and Biotechnology, 67, 197 201.
    • (2005) Applied Microbiology and Biotechnology , vol.67 , pp. 197-201
    • Thanh, N.T.1    Murthy, H.N.2    Yu, K.W.3    Hahn, E.J.4    Paek, K.Y.5
  • 46
    • 33751176445 scopus 로고    scopus 로고
    • Effect of oxygen supply on cell growth and saponin production in bioreactor cultures of Panax ginseng
    • Thanh N.T., Murthy H.N., Yu K.W., Seung Jeong C., Hahn E.J., Paek K.Y. (2006) Effect of oxygen supply on cell growth and saponin production in bioreactor cultures of Panax ginseng. Journal of Plant Physiology, 163, 1337 1341.
    • (2006) Journal of Plant Physiology , vol.163 , pp. 1337-1341
    • Thanh, N.T.1    Murthy, H.N.2    Yu, K.W.3    Seung Jeong, C.4    Hahn, E.J.5    Paek, K.Y.6
  • 48
    • 10444248004 scopus 로고    scopus 로고
    • Isoginsenoside-Rh3, a new triterpenoid saponin from the fruits of Panax ginseng C. A. Mey
    • Wang J.Y., Li X.G., Zheng Y.N., Yang X.W. (2004) Isoginsenoside-Rh3, a new triterpenoid saponin from the fruits of Panax ginseng C. A. Mey. Journal of Asian Natural Products Research, 6, 289 293.
    • (2004) Journal of Asian Natural Products Research , vol.6 , pp. 289-293
    • Wang, J.Y.1    Li, X.G.2    Zheng, Y.N.3    Yang, X.W.4
  • 49
    • 33644768323 scopus 로고    scopus 로고
    • Efficient induction of ginsenoside biosynthesis and alteration of ginsenoside heterogeneity in cell cultures of Panax notoginseng by using chemically synthesized 2-hydroxyethyl jasmonate
    • Wang W., Zhao Z.J., Xu Y., Qian X., Zhong J.J. (2006) Efficient induction of ginsenoside biosynthesis and alteration of ginsenoside heterogeneity in cell cultures of Panax notoginseng by using chemically synthesized 2-hydroxyethyl jasmonate. Applied Microbiology and Biotechnology, 70, 298 307.
    • (2006) Applied Microbiology and Biotechnology , vol.70 , pp. 298-307
    • Wang, W.1    Zhao, Z.J.2    Xu, Y.3    Qian, X.4    Zhong, J.J.5
  • 50
    • 4944264514 scopus 로고    scopus 로고
    • Selection of high ginsenoside producing ginseng hairy root lines using targeted metabolic analysis
    • Woo S.S., Song J.S., Lee J.Y., In D.S., Chung H.J., Liu J.R., Choi D.W. (2004) Selection of high ginsenoside producing ginseng hairy root lines using targeted metabolic analysis. Phytochemistry, 65, 2751 2761.
    • (2004) Phytochemistry , vol.65 , pp. 2751-2761
    • Woo, S.S.1    Song, J.S.2    Lee, J.Y.3    In, D.S.4    Chung, H.J.5    Liu, J.R.6    Choi, D.W.7
  • 51
    • 34147163865 scopus 로고    scopus 로고
    • Medicinal flowers. XI. Structures of new dammarane-type triterpene diglycosides with hydroperoxide group from flower buds of Panax ginseng
    • Yoshikawa M., Sugimoto S., Nakamura S., Matsuda H. (2007) Medicinal flowers. XI. Structures of new dammarane-type triterpene diglycosides with hydroperoxide group from flower buds of Panax ginseng. Chemical & Pharmaceutical Bulletin, 55, 571 576.
    • (2007) Chemical & Pharmaceutical Bulletin , vol.55 , pp. 571-576
    • Yoshikawa, M.1    Sugimoto, S.2    Nakamura, S.3    Matsuda, H.4
  • 52
    • 0034942164 scopus 로고    scopus 로고
    • Biosynthesis of 2-methyl-3-buten-2-ol emitted from needles of Pinus ponderosa via the non-mevalonate DOXP/MEP pathway of isoprenoid formation
    • Zeidler J., Lichtenthaler H.K. (2001) Biosynthesis of 2-methyl-3-buten-2-ol emitted from needles of Pinus ponderosa via the non-mevalonate DOXP/MEP pathway of isoprenoid formation. Planta, 213, 323 326.
    • (2001) Planta , vol.213 , pp. 323-326
    • Zeidler, J.1    Lichtenthaler, H.K.2


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