Modulation of nucleocytoplasmic trafficking by retention in cytoplasm or nucleus

Journal of Cellular Biochemistry

Volumn 107, Issue 6, 2009, Pages 1160-1167

  Roth, Daniela M ^a,b   Harper, Ian ^a   Pouton, Colin W ^b   Jans, David A ^a  

^a MONASH UNIVERSITY   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

Frap; Nuclear export; Nuclear import; Retinoblastoma protein; SV40 large tumor antigen

Indexed keywords

EXPORTIN 1; GREEN FLUORESCENT PROTEIN; RETINOBLASTOMA PROTEIN; SV40 LARGE TUMOR ANTIGEN; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; HUMAN; HUMAN CELL; NUCLEAR LOCALIZATION SIGNAL; NUCLEOCYTOPLASMIC TRANSPORT; PRIORITY JOURNAL;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ANTIGENS, POLYOMAVIRUS TRANSFORMING; CELL NUCLEUS; CERCOPITHECUS AETHIOPS; COS CELLS; CYTOPLASM; KARYOPHERINS; KINETICS; NUCLEAR LOCALIZATION SIGNALS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RETINOBLASTOMA PROTEIN; TRANSFECTION;

EID: 68049110292     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22218     Document Type: Article

References (35)

1. Alvisi G, Jans DA, Guo J, Pinna LA, Ripalti A. 2005. A protein kinase CK2 site flanking the nuclear targeting signal enhances nuclear transport of human cytomegalovirus ppUL44. Traffic 6:1002-1013. (Pubitemid 41472459)
2. Carrero G, McDonald D, Crawford E, de Vries G, Hendzel MJ. 2003. Using FRAP and mathematical modeling to determine the in vivo kinetics of nuclear proteins. Methods 29:14-28. (Pubitemid 36259909)
3. Chan CK, Jans DA. 2002. Using nuclear targeting signals to enhance non-viral gene transfer. Immunol Cell Biol 80:119-130.
4. Daigle N, Beaudouin J, Hartnell L, Imreh G, Hallberg E, Lippincott-Schwartz J, Ellenberg J. 2001. Nuclear pore complexes form immobile networks and have a very low turnover in live mammalian cells. J Cell Biol 154:71-84. (Pubitemid 34289279)
5. Dohner K, Wolfstein A, Prank U, Echeverri C, Dujardin D, Vallee R, Sodeik B. 2002. Function of dynein and dynactin in herpes simplex virus capsid transport. Mol Biol Cell 13:2795-2809. (Pubitemid 34907104)
6. Efthymiadis A, Shao H, Hubner S, Jans DA. 1997. Kinetic characterization of the human retinoblastoma protein bipartite nuclear localization sequence (NLS) in vivo and in vitro. A comparison with the SV40 large T-antigen NLS. J Biol Chem 272:22134-22139. (Pubitemid 27382842)
7. Ellenberg J, Lippincott-Schwartz J. 1999. Dynamics and mobility of nuclear envelope proteins in interphase and mitotic cells revealed by green fluorescent protein chimeras. Methods 19:362-372. (Pubitemid 30028595)
8. Fornerod M, Ohno M, Yoshida M, Mattaj IW. 1997. CRM1 is an export receptor for leucine-rich nuclear export signals. Cell 90:1051-1060. (Pubitemid 27408519)
9. Forwood JK, Jans DA. 2002. Nuclear import pathway of the telomere elongation suppressor TR F1. inhibition by importin alpha. Biochemistry 41:9333-9340.
10. Ghildyal R, Ho A, Wagstaff KM, Dias MM, Barton CL, Jans P, Bardin P, Jans DA. 2005. Nuclear import of the respiratory syncytial virus matrix protein is mediated by importin beta1 independent of importin alpha. Biochemistry 44:12887-12895. (Pubitemid 41377328)
11. Giannakakou P, Sackett DL, Ward Y, Webster KR, Blagosklonny MV, Fojo T. 2000. p53 is associated with cellular microtubules and is transported to the nucleus by dynein. Nat Cell Biol 2:709-717. (Pubitemid 30768153)
12. Gorlich D, Kutay U. 1999. Transport between the cell nucleus and the cytoplasm. Annu Rev Cell Dev Biol 15:607-660.
13. Griffis ER, Altan N, Lippincott-Schwartz J, Powers MA. 2002. Nup98 is a mobile nucleoporin with transcription-dependent dynamics. Mol Biol Cell 13:1282-1297. (Pubitemid 34309623)
14. Harley VR, Layfield S, Mitchell CL, Forwood JK, John AP, Briggs LJ, McDowall SG, Jans DA. 2003. Defective importin beta recognition and nuclear import of the sex-determining factor SRY are associated with XY sex-reversing mutations. Proc Natl Acad Sci USA 100:7045-7050. (Pubitemid 36706390)
15. Henderson BR, Percipalle P. 1997. Interactions between HIV Rev and nuclear import and export factors: The Rev nuclear localisation signal mediates specific binding to human importin-beta. J Mol Biol 274:693-707. (Pubitemid 28021339)
16. Hu W, Kemp BE, Jans DA. 2005. Kinetic properties of nuclear transport conferred by the retinoblastoma (Rb) NLS. J Cell Biochem 95:782-793. (Pubitemid 41420165)
17. Hubner S, Xiao CY, Jans DA. 1997. The protein kinase CK2 site (Ser111/112) enhances recognition of the simian virus 40 large T-antigen nuclear localization sequence by importin. J Biol Chem 272:17191-17195. (Pubitemid 27289832)
18. Jans DA, Jans P. 1994. Negative charge at the casein kinase II site flanking the nuclear localization signal of the SV40 large T-antigen is mechanistically important for enhanced nuclear import. Oncogene 9:2961-2968. (Pubitemid 24296771)
19. Jans DA, Xiao CY, Lam MH. 2000. Nuclear targeting signal recognition: A key control point in nuclear transport? Bioessays 22:532-544.
20. Jiao W, Datta J, Lin HM, Dundr M, Rane SG. 2006. Nucleocytoplasmic shuttling of the retinoblastoma tumor suppressor protein via Cdk phosphorylation-dependent nuclear export. J Biol Chem 281:38098-38108. (Pubitemid 46042113)
21. Kimura H, Cook PR. 2001. Kinetics of core histones in living human cells: Little exchange of H3 and H4 and some rapid exchange of H2B. J Cell Biol 153:1341-1353. (Pubitemid 34286121)
22. Kruhlak MJ, Lever MA, Fischle W, Verdin E, Bazett-Jones DP, Hendzel MJ. 2000. Reduced mobility of the alternate splicing factor (ASF) through the nucleoplasm and steady state speckle compartments. J Cell Biol 150:41-51. (Pubitemid 30480225)
23. Lam MH, Briggs LJ, Hu W, Martin TJ, Gillespie MT, Jans DA. 1999. Importin beta recognizes parathyroid hormone-related protein with high affinity and mediates its nuclear import in the absence of importin alpha. J Biol Chem 274:7391-7398. (Pubitemid 129505032)
24. Lam MH, Henderson B, Gillespie MT, Jans DA. 2001. Dynamics of leptomycin B-sensitive nucleocytoplasmic flux of parathyroid hormone-related protein. Traffic 2:812-819. (Pubitemid 33040261)
25. Lam MH, Thomas RJ, Loveland KL, Schilders S, Gu M, Martin TJ, Gillespie MT, Jans DA. 2002. Nuclear transport of parathyroid hormone (PTH)-related protein is dependent on microtubules. Mol Endocrinol 16:390-401. (Pubitemid 34131233)
26. Launholt D, Merkle T, Houben A, Schulz A, Grasser KD. 2006. Arabidopsis chromatin-associated HMGA and HMGB use different nuclear targeting signals and display highly dynamic localization within the nucleus. Plant Cell 18:2904-2918. (Pubitemid 46013265)
27. Markiewicz E, Dechat T, Foisner R, Quinlan RA, Hutchison CJ. 2002. Lamin A/C binding protein LAP2alpha is required for nuclear anchorage of retinoblastoma protein. Mol Biol Cell 13:4401-4413. (Pubitemid 35471194)
28. Nicolas FJ, De Bosscher K, Schmierer B, Hill CS. 2004. Analysis of Smad nucleocytoplasmic shuttling in living cells. J Cell Sci 117:4113-4125. (Pubitemid 39328299)
29. Phair RD, Misteli T. 2000. High mobility of proteins in the mammalian cell nucleus. Nature 404:604-609. (Pubitemid 30205058)
30. Roth DM, Moseley GW, Glover D, Pouton CW, Jans DA. 2007. A microtubule-facilitated nuclear import pathway for cancer regulatory proteins. Traffic 8:673-686. (Pubitemid 46785150)
31. Schmierer B, Hill CS. 2005. Kinetic analysis of Smad nucleocytoplasmic shuttling reveals a mechanism for transforming growth factor beta-dependent nuclear accumulation of Smads. Mol Cell Biol 25:9845-9858. (Pubitemid 41572734)
32. Seydel U, Jans DA. 1996. Evidence for an inhibitory feedback loop regulating simian virus 40 large T-antigen fusion protein nuclear transport. Biochem J 315(Pt 1): 33-39. (Pubitemid 26113532)
33. Sunn KL, Eisman JA, Gardiner EM, Jans DA. 2005. FRAP analysis of nucleocytoplasmic dynamics of the vitamin D receptor splice variant VDR B1: Preferential targeting to nuclear speckles. Biochem J 388:509-514.
34. Templeton DJ. 1992. Nuclear binding of purified retinoblastoma gene product is determined by cell cycle-regulated phosphorylation. Mol Cell Biol 12:435-443.
35. VanLoock MS, Alexandrov A, Yu X, Cozzarelli NR, Egelman EH. 2002. SV40 large T antigen hexamer structure: Domain organization and DNA-induced conformational changes. Curr Biol 12:472-476. (Pubitemid 34248893)