Specificity of procaine and ester hydrolysis by human, minipig, and rat skin and liver

Drug Metabolism and Disposition

Volumn 35, Issue 11, 2007, Pages 2015-2022

  Jewell, Christopher ^a   Ackermann, Chrisita ^b   Payne, N Ann ^b   Fate, Gwendolyn ^b   Voorman, Richard ^b   Williams, Faith M ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLSULFONYL FLUORIDE; BIS NITROPHENYL PHOSPHATE; CARBOXYLESTERASE; ESTER; LOPERAMIDE; MERCURIC CHLORIDE; PARAOXON; PROCAINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME ASSAY; HUMAN; HYDROLYSIS; MALE; MINIPIG; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN ABSORPTION;

ANIMALS; ENZYME INHIBITORS; ESTERASES; ESTERS; FEMALE; HUMANS; HYDROLYSIS; LIVER; LOPERAMIDE; MALE; MICROSOMES, LIVER; MOLECULAR STRUCTURE; NITROPHENOLS; PARAOXON; PENTANOIC ACIDS; PHENYLACETATES; PHENYLMETHYLSULFONYL FLUORIDE; PROCAINE; RATS; RATS, WISTAR; SKIN; SWINE; SWINE, MINIATURE; UMBELLIFERONES;

ANIMALIA; RATTUS;

EID: 34547671307     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.107.015727     Document Type: Article

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