HSP70 colocalizes with PLK1 at the centrosome and disturbs spindle dynamics in cells arrested in mitosis by arsenic trioxide

Archives of Toxicology

Volumn 88, Issue 9, 2014, Pages 1711-1723

  Chen, Yu Ju ^a,b   Lai, Kuo Chu ^c   Kuo, Hsiao Hui ^d   Chow, Lu Ping ^b   Yih, Ling Huei ^d   Lee, Te Chang ^a  

^a INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c TZU CHI UNIVERSITY   (Taiwan)

^d INSTITUTE OF CELLULAR AND ORGANISMIC BIOLOGY   (Taiwan)

Author keywords

Arsenic trioxide; Centrosome; HSP70; Mitotic arrest; Mitotic spindle; PLK1

Indexed keywords

ARSENIC TRIOXIDE; HEAT SHOCK PROTEIN 70; NOCODAZOLE; POLO LIKE KINASE 1; SMALL INTERFERING RNA; AGENTS AFFECTING CELL DIVISION; CARCINOGEN; CELL CYCLE PROTEIN; MUTANT PROTEIN; ONCOPROTEIN; ORGANOARSENIC DERIVATIVE; OXIDE; POLO-LIKE KINASE 1; PROTEIN SERINE THREONINE KINASE; RECOMBINANT PROTEIN; TUBULIN MODULATOR;

ANTIGEN ANTIBODY COMPLEX; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL ELONGATION; CELL VIABILITY; CELLULAR DISTRIBUTION; CENTROSOME; CYTOPLASM; DEPOLYMERIZATION; EXPRESSION VECTOR; FLUORESCENCE MICROSCOPY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; MICROTUBULE; MITOSIS INHIBITION; MITOSIS SPINDLE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; WILD TYPE; AMINO ACID SUBSTITUTION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; GENE SILENCING; GENETICS; HEK293 CELL LINE; HELA CELL LINE; METABOLISM; MITOSIS; PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN TRANSPORT; SPINDLE APPARATUS;

AMINO ACID SUBSTITUTION; APOPTOSIS; ARSENICALS; CARCINOGENS, ENVIRONMENTAL; CELL CYCLE PROTEINS; CENTROSOME; GENE SILENCING; HEK293 CELLS; HELA CELLS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MITOSIS; MITOSIS MODULATORS; MUTANT PROTEINS; OXIDES; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; RECOMBINANT PROTEINS; SPINDLE APPARATUS; TUBULIN MODULATORS;

EID: 84906251132     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1222-x     Document Type: Article

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