Toxicity of Copper on Isolated Liver Mitochondria: Impairment at Complexes I, II, and IV Leads to Increased ROS Production

Cell Biochemistry and Biophysics

Volumn 70, Issue 1, 2014, Pages 367-381

  Hosseini, Mir Jamal ^a,b   Shaki, Fatemeh ^a,c   Ghazi Khansari, Mahmoud ^d   Pourahmad, Jalal ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ZANJAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Isolated mitochondria; Respiratory complexes; Toxicity

Indexed keywords

RATTUS;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; BIOLOGICAL MARKER; COPPER; CYTOCHROME; CYTOCHROME C OXIDASE; GLUTATHIONE; MULTIENZYME COMPLEX; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE);

ANIMAL; BLOOD; CYTOLOGY; DRUG EFFECTS; ENZYMOLOGY; LIPID PEROXIDATION; LIVER; LIVER MITOCHONDRION; MALE; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION SWELLING; PHYSIOLOGY; RAT; SECRETION (PROCESS); WISTAR RAT;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANIMALS; BIOLOGICAL MARKERS; COPPER; CYTOCHROMES; ELECTRON TRANSPORT CHAIN COMPLEX PROTEINS; ELECTRON TRANSPORT COMPLEX I; ELECTRON TRANSPORT COMPLEX II; ELECTRON TRANSPORT COMPLEX IV; GLUTATHIONE; LIPID PEROXIDATION; LIVER; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA, LIVER; MITOCHONDRIAL SWELLING; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES;

EID: 84906216387     PISSN: 10859195     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12013-014-9922-7     Document Type: Article

References (42)

1. Gaetke, L. M., & Chow, C. K. (2003). Copper toxicity, oxidative stress, and antioxidant nutrients. Toxicology, 189, 147-163.
2. Pourahmad, J., & O'Brien, P. J. (2000). Contrasting role of Na + ions in modulating Cu2 + or Cd2 + induced hepatocyte toxicity. Chemico-Biological Interactions, 126, 159-169.
3. Schilsky, M. L. (1996). Wilson's disease: genetic basis of copper toxicity and natural history. Seminars in Liver Disease, 16(l), 83-95.
4. Britton, R. S. (1996). Metal-induced hepatotoxicity. Seminars in Liver Disease, 16, 3-12.
5. Pourahmad, J., & O'Brien, P. J. (2000). A comparison of hepatocyte cytotoxic mechanisms for Cu2+ and Cd2+. Toxicology, 143, 263-273.
6. Pourahmad, J., Mihajlovic, A., & O'Brien, P. J. (2001). Hepatocyte lysis induced by environmental metal toxins may involve apoptotic death signals initiated by mitochondrial injury. Advances in Experimental Medicine and Biology, 5002, 49-52.
7. Pourahmad, J., Ross, S., & O'Brien, P. J. (2001). Lysosomal involvement in hepatocyte cytotoxicity induced by Cu2+ but not Cd2+. Free Radical Biology and Medicine, 30, 89-97.
8. Winge, D. R., & Mehra, R. K. (1990). Host defenses against copper toxicity. International Review of Experimental Pathology, 31, 47-83.
9. Zhang, S. S. Z., Noordin, M. M., Rahman, S. O. A., & Haron, J. (2000). Effects of copper overload on hepatic lipid peroxidation and antioxidant defense in rats. Veterinary and Human Toxicology, 42, 261-264.
10. Mehta, R., Templeton, D. M., & O'Brien, P. J. (2006). Mitochondrial involvement in genetically determined transition metal toxicity II. Copper toxicity. Chemico-Biological Interactions, 163, 77-85.
11. Brewer, G. J. (2005). Anti-copper therapy against cancer and diseases of inflammation and fibrosis. Drug Discovery Today, 10, 1103-1109.
12. Arciello, M., Rotilio, G., & Rossi, L. (2005). Copper-dependent toxicity in SH-SY5Y neuroblastoma cells involves mitochondrial damage. Biochem and Biophysical Research Communications, 327, 454-459.
13. Kawakama, M., Inagawa, R., Hosokawa, T., Satio, T., & Kurasaki, M. (2008). Mechanism of apoptosis induced by copper in PC12 cells. Food and Chemical Toxicology, 46, 2157-2164.
14. Valko, M., Morris, H., & Cronin, M. T. (2005). Metals, toxicity and oxidative stress. Current Medicinal Chemistry, 12, 1161-1208.
15. Boveris, A., Musacco-Sebio, R., Ferrarotti, N., Saporito-Magriñá, C., Torti, H., Massot, F., et al. (2012). The acute toxicity of iron and copper: biomolecule oxidation and oxidative damage in rat liver. Journal of Inorganic Biochemistry, 116, 63-69.
16. Ghazi-khansari, M., Mohammadi-Bardbori, A., & Hosseini, M.-J. (2006). Using Janus Green B to study paraquat toxicity in rat liver mitochondria role of ACE inhibitors (Thiol and Nonthiol ACEi). Annals of the New York Academy of Sciences, 1090, 98-107.
17. Bradford, M. M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry, 72, 248-254.
18. Gao, X., Zheng, C. Y., Yang, L., Tang, X. C., & Zhang, H. Y. (2009). Huperzine A protects isolated rat brain mitochondria against β-amyloid peptide. Free Radical Biology and Medicine, 46, 1454-1462.
19. Barja, G. (2002). The Quantitative Measurement of H2O2 Generation in Isolated Mitochondria. Journal of Bioenergetics and Biomembranes, 34, 227-233.
20. Zhao, Y., Ye, L., Liu, H., Xia, Q., Zhang, Y., Yang, X., et al. (2010). Vanadium compounds induced mitochondria permeability transition pore (MPT) opening related to oxidative stress. Journal of Inorganic Biochemistry, 104, 371-378.
21. Zhang, F., Xu, Z., Gao, J., Xu, B., & Deng, Y. (2008). In vitro effect of manganese chloride exposure on energy metabolism and oxidative damage of mitochondria isolated from rat brain. Environmental Toxicology and Pharmacology, 26, 232-236.
22. Sadegh, C., & Schreck, R. P. (2003). The spectroscopic determination of aqueous sulfite using Ellman's reagent. MIT Undergraduate Research Journal, 8, 39-43.
23. Baracca, A., Sgarbi, G., Solaini, G., & Lenaz, G. (2003). Rhodamine 123 as a probe of mitochondrial membrane potential: evaluation of proton flux through F(0) during ATP synthesis. Biochimica et Biophysica Acta, 1606, 137-146.
24. Tafreshi, N. K., Hosseinkhani, S., Sadeghizadeh, M., Sadeghi, M., Ranjbar, B., & Naderi-Manesh, H. (2007). The influence of insertion of a critical residue (Arg356) in structure and bioluminescence spectra of firefly luciferase. Journal of Biological Chemistry, 282, 8641-8647.
25. Drew, B., & Leeuwenburgh, C. (2003). Method for measuring ATP production in isolated mitochondria: ATP production in brain and liver mitochondria of Fischer-344 rats with age and caloric restriction. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 28, 1259-1268.
26. Belyaeva, E. A., Korotkov, S. M., & Saris, N. E. (2011). In vitro modulation of heavy metal-induced rat liver mitochondria dysfunction: a comparison of copper and mercury with cadmium. Journal of Trace Elements in Medicine and Biology, 25, 63-73.
27. White, A. R., Huang, X., Jobling, M. F., Barrow, C. J., Beyreuther, K., Masters, C. L., et al. (2001). Homocysteine potentiates copper- and amyloid beta peptide peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways. Journal of Neurochemistry, 76, 1509-1520.
28. Goldfrank, L. R., Flomenbaum, F. E., & Lewin, N. A. (1998). Goldfrank's toxicologic emergencies, 6 (th ed., pp. 1339-1340). Stamford: Appleton and Lange.
29. Pourahmad, J., Stohs, S. J., & Bagchi, D. (1995). Oxidative mechanisms in the toxicity of metal ions. Free Radical Biology and Medicine, 18, 321-3685.
30. Pourahmad, J., Hosseini, M.-J., Bakan, S., & Ghazi-Khansari, M. (2011). Hepatoprotective activity of angiotensin-converting enzyme (ACE) inhibitors, captopril and enalapril, against paraquat toxicity. Pesticide Biochemistry and Physiology, 99, 105-110.
31. Belyaeva, E. A., Dymkowska, D., Wieckowski, M. R., & Wojtczak, L. (2008). Mitochondria as an important target in heavy metal toxicity in rat hepatoma AS30D cells. Toxicology and Applied Pharmacology, 231, 34-42.
32. Fattoretti, P., Vecchiet, J., Felzani, G., Gracciotti, N., Solazzi, M., Caselli, U., et al. (2001). Succinic dehydrogenase activity in human muscle mitochondria during aging: a quantitative cytochemical investigation. Mechanisms of Ageing and Development, 122, 1841-1848.
33. Nadanaciva, S., Bernal, A., Aggeler, R., Capaldi, R., & Will, Y. (2007). Target identification of drug induced mitochondrial toxicity using immunocapture based OXPHOS activity assays. Toxicology in Vitro, 21, 902-911.
34. Jones, T. T., & Brewer, G. J. (2010). Age-related deficiencies in complex I endogenous substrate availability and reserve capacity of complex IV in cortical neuron electron transport. Biochimica et Biophysica Acta, 1797, 167-176.
35. Seth, R., Yang, S., Choi, S., Sabean, M., & Roberts, E. A. (2004). In vitro assessment of copper-induced toxicity in the human hepatoma line, Hep G2. Toxicology in Vitro, 18, 501-509.
36. Zoratti, M., & Szabo, I. (1995). The mitochondrial permeability transition. Biochimica et Biophysica Acta, 1241, 139-176.
37. Krumschnabel, G., Manzl, C., Berger, C., & Hofer, B. (2005). Oxidative stress, mitochondrial permeability transition, and cell death in Cu-exposed trout hepatocytes. Toxicology and Applied Pharmacology, 209, 62-73.
38. Eguchi, Y., Shimizu, S., & Tsujimoto, Y. (1997). Intracellular ATP levels determine cell death fate by apoptosis or necrosis. Cancer Research, 57, 1835-1840.
39. Simmons, T. D., Slater, K. J., & Crouch, S. P. M. (2001). Changes in intracellular ADP: ATP ratio as a marker of apoptosis. Miami Nature Biotechnology-Winter Symposium, 1, 58.
40. Suzuki, S., Higuchi, M., Proske, R. J., Oridate, N., Hong, W. K., & Lotan, R. (1999). Implication of mitochondria-derived reactive oxygen species, cytochrome C and caspase-3 in N-(4-hydroxyphenyl) retinamide-induced apoptosis in cervical carcinoma cells. Oncogene, 18, 6380-6387.
41. Fortunato, F., Deng, X., Gates, L. K., McClain, C. J., Bimmler, D., Graf, R., et al. (2006). Pancreatic response to endotoxin after chronic alcohol exposure: switch from apoptosis to necrosis? American Journal of Physiology. Gastrointestinal and Liver Physiology, 290, 232-241.
42. Orrenius, S., Gogvadze, V., & Zhivotovsky, B. (2007). Mitochondrial oxidative stress: implications for cell death. Annual Review of Pharmacology and Toxicology, 47, 143-183.