-
1
-
-
33751523289
-
Fission yeast Tor2 promotes cell growth and represses cell differentiation
-
Alvarez B, Moreno S (2006) Fission yeast Tor2 promotes cell growth and represses cell differentiation. J Cell Sci 119: 4475-4485
-
(2006)
J Cell Sci
, vol.119
, pp. 4475-4485
-
-
Alvarez, B.1
Moreno, S.2
-
2
-
-
38649105202
-
Regulation of ceramide biosynthesis by TOR complex 2
-
Aronova S, Wedaman K, Aronov PA, Fontes K, Ramos K, Hammock BD, Powers T (2008) Regulation of ceramide biosynthesis by TOR complex 2. Cell Metab 7: 148-158
-
(2008)
Cell Metab
, vol.7
, pp. 148-158
-
-
Aronova, S.1
Wedaman, K.2
Aronov, P.A.3
Fontes, K.4
Ramos, K.5
Hammock, B.D.6
Powers, T.7
-
3
-
-
0030021524
-
TOR controls translation initiation and early G1 progression in yeast
-
Barbet NC, Schneider U, Helliwell SB, Stansfield I, Tuite MF, Hall MN (1996) TOR controls translation initiation and early G1 progression in yeast. Mol Biol Cell 7: 25-42
-
(1996)
Mol Biol Cell
, vol.7
, pp. 25-42
-
-
Barbet, N.C.1
Schneider, U.2
Helliwell, S.B.3
Stansfield, I.4
Tuite, M.F.5
Hall, M.N.6
-
4
-
-
84864968016
-
Brc1-dependent recovery from replication stress
-
Bass KL, Murray JM, O'Connell MJ (2012) Brc1-dependent recovery from replication stress. J Cell Sci 125: 2753-2764
-
(2012)
J Cell Sci
, vol.125
, pp. 2753-2764
-
-
Bass, K.L.1
Murray, J.M.2
O'Connell, M.J.3
-
5
-
-
84897524426
-
What we talk about when we talk about nuclear actin
-
Belin BJ, Mullins RD (2013) What we talk about when we talk about nuclear actin. Nucleus 4: 291-297
-
(2013)
Nucleus
, vol.4
, pp. 291-297
-
-
Belin, B.J.1
Mullins, R.D.2
-
6
-
-
84860501617
-
Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis
-
Berchtold D, Piccolis M, Chiaruttini N, Riezman I, Riezman H, Roux A, Walther TC, Loewith R (2012) Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis. Nat Cell Biol 14: 542-547
-
(2012)
Nat Cell Biol
, vol.14
, pp. 542-547
-
-
Berchtold, D.1
Piccolis, M.2
Chiaruttini, N.3
Riezman, I.4
Riezman, H.5
Roux, A.6
Walther, T.C.7
Loewith, R.8
-
7
-
-
20244365941
-
The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation
-
Beuvink I, Boulay A, Fumagalli S, Zilbermann F, Ruetz S, O'Reilly T, Natt F, Hall J, Lane HA, Thomas G (2005) The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation. Cell 120: 747-759
-
(2005)
Cell
, vol.120
, pp. 747-759
-
-
Beuvink, I.1
Boulay, A.2
Fumagalli, S.3
Zilbermann, F.4
Ruetz, S.5
O'Reilly, T.6
Natt, F.7
Hall, J.8
Lane, H.A.9
Thomas, G.10
-
8
-
-
42949165854
-
PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival
-
Bozulic L, Surucu B, Hynx D, Hemmings BA (2008) PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival. Mol Cell 30: 203-213
-
(2008)
Mol Cell
, vol.30
, pp. 203-213
-
-
Bozulic, L.1
Surucu, B.2
Hynx, D.3
Hemmings, B.A.4
-
9
-
-
0037027880
-
DNA structure dependent checkpoints as regulators of DNA repair
-
Carr AM (2002) DNA structure dependent checkpoints as regulators of DNA repair. DNA Repair (Amst) 1: 983-994
-
(2002)
DNA Repair (Amst)
, vol.1
, pp. 983-994
-
-
Carr, A.M.1
-
11
-
-
84899850988
-
Picking the point of inhibition: a comparative review of PI3K/AKT/mTOR pathway inhibitors
-
Dienstmann R, Rodon J, Serra V, Tabernero J (2014) Picking the point of inhibition: a comparative review of PI3K/AKT/mTOR pathway inhibitors. Mol Cancer Ther 18: 1021-1031
-
(2014)
Mol Cancer Ther
, vol.18
, pp. 1021-1031
-
-
Dienstmann, R.1
Rodon, J.2
Serra, V.3
Tabernero, J.4
-
12
-
-
47949125486
-
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
-
Facchinetti V, Ouyang W, Wei H, Soto N, Lazorchak A, Gould C, Lowry C, Newton AC, Mao Y, Miao RQ et al (2008) The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J 27: 1932-1943
-
(2008)
EMBO J
, vol.27
, pp. 1932-1943
-
-
Facchinetti, V.1
Ouyang, W.2
Wei, H.3
Soto, N.4
Lazorchak, A.5
Gould, C.6
Lowry, C.7
Newton, A.C.8
Mao, Y.9
Miao, R.Q.10
-
13
-
-
79952216582
-
Reduced VEGF production, angiogenesis, and vascular regrowth contribute to the antitumor properties of dual mTORC1/mTORC2 inhibitors
-
Falcon BL, Barr S, Gokhale PC, Chou J, Fogarty J, Depeille P, Miglarese M, Epstein DM, McDonald DM (2011) Reduced VEGF production, angiogenesis, and vascular regrowth contribute to the antitumor properties of dual mTORC1/mTORC2 inhibitors. Cancer Res 71: 1573-1583
-
(2011)
Cancer Res
, vol.71
, pp. 1573-1583
-
-
Falcon, B.L.1
Barr, S.2
Gokhale, P.C.3
Chou, J.4
Fogarty, J.5
Depeille, P.6
Miglarese, M.7
Epstein, D.M.8
McDonald, D.M.9
-
14
-
-
78651330430
-
COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
-
Forbes SA, Bindal N, Bamford S, Cole C, Kok CY, Beare D, Jia M, Shepherd R, Leung K, Menzies A et al (2011) COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer. Nucleic Acids Res 39: D945-D950
-
(2011)
Nucleic Acids Res
, vol.39
-
-
Forbes, S.A.1
Bindal, N.2
Bamford, S.3
Cole, C.4
Kok, C.Y.5
Beare, D.6
Jia, M.7
Shepherd, R.8
Leung, K.9
Menzies, A.10
-
16
-
-
58649092475
-
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
-
Garcia-Martinez JM, Alessi DR (2008) mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). Biochem J 416: 375-385
-
(2008)
Biochem J
, vol.416
, pp. 375-385
-
-
Garcia-Martinez, J.M.1
Alessi, D.R.2
-
17
-
-
84876848854
-
Novel approaches for molecular targeted therapy of breast cancer: interfering with PI3K/AKT/mTOR signaling
-
Grunt TW, Mariani GL (2013) Novel approaches for molecular targeted therapy of breast cancer: interfering with PI3K/AKT/mTOR signaling. Curr Cancer Drug Targets 13: 188-204
-
(2013)
Curr Cancer Drug Targets
, vol.13
, pp. 188-204
-
-
Grunt, T.W.1
Mariani, G.L.2
-
18
-
-
58649114084
-
mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice
-
Guertin DA, Stevens DM, Saitoh M, Kinkel S, Crosby K, Sheen JH, Mullholland DJ, Magnuson MA, Wu H, Sabatini DM (2009) mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Cancer Cell 15: 148-159
-
(2009)
Cancer Cell
, vol.15
, pp. 148-159
-
-
Guertin, D.A.1
Stevens, D.M.2
Saitoh, M.3
Kinkel, S.4
Crosby, K.5
Sheen, J.H.6
Mullholland, D.J.7
Magnuson, M.A.8
Wu, H.9
Sabatini, D.M.10
-
19
-
-
84891847714
-
mTOR kinase inhibitor sensitizes T-cell lymphoblastic leukemia for chemotherapy-induced DNA damage via suppressing FANCD2 expression
-
Guo F, Li J, Zhang S, Du W, Amarachintha S, Sipple J, Phelan J, Grimes HL, Zheng Y, Pang Q (2014) mTOR kinase inhibitor sensitizes T-cell lymphoblastic leukemia for chemotherapy-induced DNA damage via suppressing FANCD2 expression. Leukemia 28: 203-206
-
(2014)
Leukemia
, vol.28
, pp. 203-206
-
-
Guo, F.1
Li, J.2
Zhang, S.3
Du, W.4
Amarachintha, S.5
Sipple, J.6
Phelan, J.7
Grimes, H.L.8
Zheng, Y.9
Pang, Q.10
-
20
-
-
0037148529
-
The conserved Pkh-Ypk kinase cascade is required for endocytosis in yeast
-
deHart AK, Schnell JD, Allen DA, Hicke L (2002) The conserved Pkh-Ypk kinase cascade is required for endocytosis in yeast. J Cell Biol 156: 241-248
-
(2002)
J Cell Biol
, vol.156
, pp. 241-248
-
-
deHart, A.K.1
Schnell, J.D.2
Allen, D.A.3
Hicke, L.4
-
22
-
-
36749055217
-
Rapamycin sensitivity of the S. pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits
-
Hayashi T, Hatanaka M, Nagao K, Nakaseko Y, Kanoh J, Kokubu A, Ebe M, Yanagida M (2007) Rapamycin sensitivity of the S. pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits. Genes Cells 12: 1357-1370
-
(2007)
Genes Cells
, vol.12
, pp. 1357-1370
-
-
Hayashi, T.1
Hatanaka, M.2
Nagao, K.3
Nakaseko, Y.4
Kanoh, J.5
Kokubu, A.6
Ebe, M.7
Yanagida, M.8
-
23
-
-
0025776523
-
Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
-
Heitman J, Movva NR, Hall MN (1991) Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 253: 905-909
-
(1991)
Science
, vol.253
, pp. 905-909
-
-
Heitman, J.1
Movva, N.R.2
Hall, M.N.3
-
24
-
-
33947330747
-
Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth
-
Hietakangas V, Cohen SM (2007) Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth. Genes Dev 21: 632-637
-
(2007)
Genes Dev
, vol.21
, pp. 632-637
-
-
Hietakangas, V.1
Cohen, S.M.2
-
25
-
-
81055140318
-
The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe
-
Ikai N, Nakazawa N, Hayashi T, Yanagida M (2011) The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe. Open Biol 1: 110007
-
(2011)
Open Biol
, vol.1
, pp. 110007
-
-
Ikai, N.1
Nakazawa, N.2
Hayashi, T.3
Yanagida, M.4
-
26
-
-
40549111629
-
Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control
-
Ikeda K, Morigasaki S, Tatebe H, Tamanoi F, Shiozaki K (2008) Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control. Cell Cycle 7: 358-364
-
(2008)
Cell Cycle
, vol.7
, pp. 358-364
-
-
Ikeda, K.1
Morigasaki, S.2
Tatebe, H.3
Tamanoi, F.4
Shiozaki, K.5
-
27
-
-
47949104258
-
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
-
Ikenoue T, Inoki K, Yang Q, Zhou X, Guan KL (2008) Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J 27: 1919-1931
-
(2008)
EMBO J
, vol.27
, pp. 1919-1931
-
-
Ikenoue, T.1
Inoki, K.2
Yang, Q.3
Zhou, X.4
Guan, K.L.5
-
28
-
-
39749100492
-
TOR regulation of AGC kinases in yeast and mammals
-
Jacinto E, Lorberg A (2008) TOR regulation of AGC kinases in yeast and mammals. Biochem J 410: 19-37
-
(2008)
Biochem J
, vol.410
, pp. 19-37
-
-
Jacinto, E.1
Lorberg, A.2
-
29
-
-
23344448223
-
Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization
-
Kamada Y, Fujioka Y, Suzuki NN, Inagaki F, Wullschleger S, Loewith R, Hall MN, Ohsumi Y (2005) Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization. Mol Cell Biol 25: 7239-7248
-
(2005)
Mol Cell Biol
, vol.25
, pp. 7239-7248
-
-
Kamada, Y.1
Fujioka, Y.2
Suzuki, N.N.3
Inagaki, F.4
Wullschleger, S.5
Loewith, R.6
Hall, M.N.7
Ohsumi, Y.8
-
30
-
-
0035006616
-
Fission yeast tor1 functions in response to various stresses including nitrogen starvation, high osmolarity, and high temperature
-
Kawai M, Nakashima A, Ueno M, Ushimaru T, Aiba K, Doi H, Uritani M (2001) Fission yeast tor1 functions in response to various stresses including nitrogen starvation, high osmolarity, and high temperature. Curr Genet 39: 166-174
-
(2001)
Curr Genet
, vol.39
, pp. 166-174
-
-
Kawai, M.1
Nakashima, A.2
Ueno, M.3
Ushimaru, T.4
Aiba, K.5
Doi, H.6
Uritani, M.7
-
31
-
-
84859778293
-
mTOR signaling in growth control and disease
-
Laplante M, Sabatini DM (2012) mTOR signaling in growth control and disease. Cell 149: 274-293
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
32
-
-
84898614114
-
mTORC2 phosphorylates protein kinase Czeta to regulate its stability and activity
-
Li X, Gao T (2014) mTORC2 phosphorylates protein kinase Czeta to regulate its stability and activity. EMBO Rep 15: 191-198
-
(2014)
EMBO Rep
, vol.15
, pp. 191-198
-
-
Li, X.1
Gao, T.2
-
33
-
-
84880685419
-
Growth control: function follows form
-
Loewith R (2013) Growth control: function follows form. Curr Biol 23: R607-R609
-
(2013)
Curr Biol
, vol.23
-
-
Loewith, R.1
-
34
-
-
83455177213
-
Target of rapamycin (TOR) in nutrient signaling and growth control
-
Loewith R, Hall MN (2011) Target of rapamycin (TOR) in nutrient signaling and growth control. Genetics 189: 1177-1201
-
(2011)
Genetics
, vol.189
, pp. 1177-1201
-
-
Loewith, R.1
Hall, M.N.2
-
35
-
-
0036753494
-
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
-
Loewith R, Jacinto E, Wullschleger S, Lorberg A, Crespo JL, Bonenfant D, Oppliger W, Jenoe P, Hall MN (2002) Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 10: 457-468
-
(2002)
Mol Cell
, vol.10
, pp. 457-468
-
-
Loewith, R.1
Jacinto, E.2
Wullschleger, S.3
Lorberg, A.4
Crespo, J.L.5
Bonenfant, D.6
Oppliger, W.7
Jenoe, P.8
Hall, M.N.9
-
36
-
-
37549048521
-
mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor
-
Masri J, Bernath A, Martin J, Jo OD, Vartanian R, Funk A, Gera J (2007) mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor. Cancer Res 67: 11712-11720
-
(2007)
Cancer Res
, vol.67
, pp. 11712-11720
-
-
Masri, J.1
Bernath, A.2
Martin, J.3
Jo, O.D.4
Vartanian, R.5
Funk, A.6
Gera, J.7
-
37
-
-
0037600512
-
Schizosaccharomyces pombe AGC family kinase Gad8p forms a conserved signaling module with TOR and PDK1-like kinases
-
Matsuo T, Kubo Y, Watanabe Y, Yamamoto M (2003) Schizosaccharomyces pombe AGC family kinase Gad8p forms a conserved signaling module with TOR and PDK1-like kinases. EMBO J 22: 3073-3083
-
(2003)
EMBO J
, vol.22
, pp. 3073-3083
-
-
Matsuo, T.1
Kubo, Y.2
Watanabe, Y.3
Yamamoto, M.4
-
38
-
-
34147207884
-
Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast
-
Matsuo T, Otsubo Y, Urano J, Tamanoi F, Yamamoto M (2007) Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast. Mol Cell Biol 27: 3154-3164
-
(2007)
Mol Cell Biol
, vol.27
, pp. 3154-3164
-
-
Matsuo, T.1
Otsubo, Y.2
Urano, J.3
Tamanoi, F.4
Yamamoto, M.5
-
39
-
-
4344632329
-
Deletion of the intestinal peptide transporter affects insulin and TOR signaling in Caenorhabditis elegans
-
Meissner B, Boll M, Daniel H, Baumeister R (2004) Deletion of the intestinal peptide transporter affects insulin and TOR signaling in Caenorhabditis elegans. J Biol Chem 279: 36739-36745
-
(2004)
J Biol Chem
, vol.279
, pp. 36739-36745
-
-
Meissner, B.1
Boll, M.2
Daniel, H.3
Baumeister, R.4
-
40
-
-
0032512636
-
Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast
-
Noda T, Ohsumi Y (1998) Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J Biol Chem 273: 3963-3966
-
(1998)
J Biol Chem
, vol.273
, pp. 3963-3966
-
-
Noda, T.1
Ohsumi, Y.2
-
41
-
-
78649712949
-
mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide
-
Oh WJ, Wu CC, Kim SJ, Facchinetti V, Julien LA, Finlan M, Roux PP, Su B, Jacinto E (2010) mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. EMBO J 29: 3939-3951
-
(2010)
EMBO J
, vol.29
, pp. 3939-3951
-
-
Oh, W.J.1
Wu, C.C.2
Kim, S.J.3
Facchinetti, V.4
Julien, L.A.5
Finlan, M.6
Roux, P.P.7
Su, B.8
Jacinto, E.9
-
42
-
-
84901008792
-
Targeting PI3K/Akt/mTOR Signaling in Cancer
-
eCollection 2014
-
Porta C, Paglino C, Mosca A (2014) Targeting PI3K/Akt/mTOR Signaling in Cancer. Front Oncol 4: eCollection 2014
-
(2014)
Front Oncol
, vol.4
-
-
Porta, C.1
Paglino, C.2
Mosca, A.3
-
43
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (2005) Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307: 1098-1101
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
44
-
-
0030479340
-
TOR2 is required for organization of the actin cytoskeleton in yeast
-
Schmidt A, Kunz J, Hall MN (1996) TOR2 is required for organization of the actin cytoskeleton in yeast. Proc Natl Acad Sci U S A 93: 13780-13785
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 13780-13785
-
-
Schmidt, A.1
Kunz, J.2
Hall, M.N.3
-
45
-
-
84880078363
-
TORC2 is required to maintain genome stability during S phase in fission yeast
-
Schonbrun M, Kolesnikov M, Kupiec M, Weisman R (2013) TORC2 is required to maintain genome stability during S phase in fission yeast. J Biol Chem 288: 19649-19660
-
(2013)
J Biol Chem
, vol.288
, pp. 19649-19660
-
-
Schonbrun, M.1
Kolesnikov, M.2
Kupiec, M.3
Weisman, R.4
-
46
-
-
68949145880
-
TOR complex 2 controls gene silencing, telomere length maintenance, and survival under DNA-damaging conditions
-
Schonbrun M, Laor D, Lopez-Maury L, Bahler J, Kupiec M, Weisman R (2009) TOR complex 2 controls gene silencing, telomere length maintenance, and survival under DNA-damaging conditions. Mol Cell Biol 29: 4584-4594
-
(2009)
Mol Cell Biol
, vol.29
, pp. 4584-4594
-
-
Schonbrun, M.1
Laor, D.2
Lopez-Maury, L.3
Bahler, J.4
Kupiec, M.5
Weisman, R.6
-
47
-
-
84884592244
-
TORC2 signaling pathway guarantees genome stability in the face of DNA strand breaks
-
Shimada K, Filipuzzi I, Stahl M, Helliwell SB, Studer C, Hoepfner D, Seeber A, Loewith R, Movva NR, Gasser SM (2013) TORC2 signaling pathway guarantees genome stability in the face of DNA strand breaks. Mol Cell 51: 829-839
-
(2013)
Mol Cell
, vol.51
, pp. 829-839
-
-
Shimada, K.1
Filipuzzi, I.2
Stahl, M.3
Helliwell, S.B.4
Studer, C.5
Hoepfner, D.6
Seeber, A.7
Loewith, R.8
Movva, N.R.9
Gasser, S.M.10
-
48
-
-
74849131091
-
Targeting mTOR globally in cancer: thinking beyond rapamycin
-
Shor B, Gibbons JJ, Abraham RT, Yu K (2009) Targeting mTOR globally in cancer: thinking beyond rapamycin. Cell Cycle 8: 3831-3837
-
(2009)
Cell Cycle
, vol.8
, pp. 3831-3837
-
-
Shor, B.1
Gibbons, J.J.2
Abraham, R.T.3
Yu, K.4
-
49
-
-
77954235821
-
Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy
-
Sparks CA, Guertin DA (2010) Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy. Oncogene 29: 3733-3744
-
(2010)
Oncogene
, vol.29
, pp. 3733-3744
-
-
Sparks, C.A.1
Guertin, D.A.2
-
50
-
-
57649219414
-
In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis
-
Surucu B, Bozulic L, Hynx D, Parcellier A, Hemmings BA (2008) In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis. J Biol Chem 283: 30025-30033
-
(2008)
J Biol Chem
, vol.283
, pp. 30025-30033
-
-
Surucu, B.1
Bozulic, L.2
Hynx, D.3
Parcellier, A.4
Hemmings, B.A.5
-
51
-
-
84860816141
-
Oncogenic EGFR signaling activates an mTORC2-NF-kappaB pathway that promotes chemotherapy resistance
-
Tanaka K, Babic I, Nathanson D, Akhavan D, Guo D, Gini B, Dang J, Zhu S, Yang H, De Jesus J et al (2011) Oncogenic EGFR signaling activates an mTORC2-NF-kappaB pathway that promotes chemotherapy resistance. Cancer Discov 1: 524-538
-
(2011)
Cancer Discov
, vol.1
, pp. 524-538
-
-
Tanaka, K.1
Babic, I.2
Nathanson, D.3
Akhavan, D.4
Guo, D.5
Gini, B.6
Dang, J.7
Zhu, S.8
Yang, H.9
De Jesus, J.10
-
52
-
-
84889091074
-
Challenging resistance mechanisms to therapies for metastatic melanoma
-
Tentori L, Lacal PM, Graziani G (2013) Challenging resistance mechanisms to therapies for metastatic melanoma. Trends Pharmacol Sci 34: 656-666
-
(2013)
Trends Pharmacol Sci
, vol.34
, pp. 656-666
-
-
Tentori, L.1
Lacal, P.M.2
Graziani, G.3
-
53
-
-
44449142302
-
Nuclear actin dynamics-from form to function
-
Vartiainen MK (2008) Nuclear actin dynamics-from form to function. FEBS Lett 582: 2033-2040
-
(2008)
FEBS Lett
, vol.582
, pp. 2033-2040
-
-
Vartiainen, M.K.1
-
54
-
-
33947538050
-
Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism
-
Wan X, Harkavy B, Shen N, Grohar P, Helman LJ (2007) Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism. Oncogene 26: 1932-1940
-
(2007)
Oncogene
, vol.26
, pp. 1932-1940
-
-
Wan, X.1
Harkavy, B.2
Shen, N.3
Grohar, P.4
Helman, L.J.5
-
55
-
-
0037345059
-
Tor kinases are in distinct membrane-associated protein complexes in S. cerevisiae
-
Wedaman KP, Reinke A, Anderson S, Yates J 3rd, McCaffery JM, Powers T (2003) Tor kinases are in distinct membrane-associated protein complexes in S. cerevisiae. Mol Biol Cell 14: 1204-1220
-
(2003)
Mol Biol Cell
, vol.14
, pp. 1204-1220
-
-
Wedaman, K.P.1
Reinke, A.2
Anderson, S.3
Yates III, J.4
McCaffery, J.M.5
Powers, T.6
-
56
-
-
77954920645
-
Fission yeast TOR and rapamycin
-
Hall MN, Tamanoi F (eds), London: Elsevier
-
Weisman R (2010) Fission yeast TOR and rapamycin. In The Enzymes Structure, Function and Regulation of TOR Complexes from Yeast to Mammals Part A, Hall MN, Tamanoi F (eds), Vol. 27, pp 251-269. London: Elsevier
-
(2010)
The Enzymes Structure, Function and Regulation of TOR Complexes from Yeast to Mammals Part A
, vol.27
, pp. 251-269
-
-
Weisman, R.1
-
57
-
-
0035831446
-
+, is required for the response to starvation and other stresses via a conserved serine
-
+, is required for the response to starvation and other stresses via a conserved serine. J Biol Chem 276: 7027-7032
-
(2001)
J Biol Chem
, vol.276
, pp. 7027-7032
-
-
Weisman, R.1
Choder, M.2
-
58
-
-
34249054108
-
Opposite effects of tor1 and tor2 on nitrogen starvation responses in fission yeast
-
Weisman R, Roitburg I, Schonbrun M, Harari R, Kupiec M (2007) Opposite effects of tor1 and tor2 on nitrogen starvation responses in fission yeast. Genetics 175: 1153-1162
-
(2007)
Genetics
, vol.175
, pp. 1153-1162
-
-
Weisman, R.1
Roitburg, I.2
Schonbrun, M.3
Harari, R.4
Kupiec, M.5
-
59
-
-
84866525932
-
Charting the landscape of tandem BRCT domain-mediated protein interactions
-
Woods NT, Mesquita RD, Sweet M, Carvalho MA, Li X, Liu Y, Nguyen H, Thomas CE, Iversen ES Jr, Marsillac S et al (2012) Charting the landscape of tandem BRCT domain-mediated protein interactions. Sci Signal 5: rs6
-
(2012)
Sci Signal
, vol.5
-
-
Woods, N.T.1
Mesquita, R.D.2
Sweet, M.3
Carvalho, M.A.4
Li, X.5
Liu, Y.6
Nguyen, H.7
Thomas, C.E.8
Iversen Jr., E.S.9
Marsillac, S.10
-
60
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger S, Loewith R, Hall MN (2006) TOR signaling in growth and metabolism. Cell 124: 471-484
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
61
-
-
68049137608
-
Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin
-
Yu K, Toral-Barza L, Shi C, Zhang WG, Lucas J, Shor B, Kim J, Verheijen J, Curran K, Malwitz DJ et al (2009) Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Cancer Res 69: 6232-6240
-
(2009)
Cancer Res
, vol.69
, pp. 6232-6240
-
-
Yu, K.1
Toral-Barza, L.2
Shi, C.3
Zhang, W.G.4
Lucas, J.5
Shor, B.6
Kim, J.7
Verheijen, J.8
Curran, K.9
Malwitz, D.J.10
-
62
-
-
0034312315
-
Regulation of cellular growth by the Drosophila target of rapamycin dTOR
-
Zhang H, Stallock JP, Ng JC, Reinhard C, Neufeld TP (2000) Regulation of cellular growth by the Drosophila target of rapamycin dTOR. Genes Dev 14: 2712-2724
-
(2000)
Genes Dev
, vol.14
, pp. 2712-2724
-
-
Zhang, H.1
Stallock, J.P.2
Ng, J.C.3
Reinhard, C.4
Neufeld, T.P.5
-
63
-
-
79952293503
-
Activation of mTORC2 by association with the ribosome
-
Zinzalla V, Stracka D, Oppliger W, Hall MN (2011) Activation of mTORC2 by association with the ribosome. Cell 144: 757-768
-
(2011)
Cell
, vol.144
, pp. 757-768
-
-
Zinzalla, V.1
Stracka, D.2
Oppliger, W.3
Hall, M.N.4
-
64
-
-
78650510609
-
mTOR: from growth signal integration to cancer, diabetes and ageing
-
Zoncu R, Efeyan A, Sabatini DM (2011) mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 12: 21-35
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
, pp. 21-35
-
-
Zoncu, R.1
Efeyan, A.2
Sabatini, D.M.3
|