Synthesis and in vitro properties of trimethylamine- and phosphonate-substituted carboranylporphyrins for application in BNCT

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 6, 2008, Pages 3191-3208

  Easson, Michael W ^a   Fronczek, Frank R ^a   Jensen, Timothy J ^a   Vicente, M Graça H ^a  

^a LOUISIANA STATE UNIVERSITY   (United States)

Author keywords

BNCT; Carborane; Cellular uptake; Cytotoxicity; Porphyrin

Indexed keywords

5,10 BIS(4 DIMETHYLAMINOPHENYL) 15,20 BIS[3,5 (2 METHYLCARBORAN 1 YL)METHYLPHENYL]PORPHYRIN; 5,15 BIS(4 PHOSPHONATE DIETHYLESTER) 10,20 BIS[3,5 (2 METHYLCARBORAN 1 YL)METHYLPHENYL]PORPHYRIN; PHOSPHONIC ACID DERIVATIVE; PORPHYRIN DERIVATIVE; TRIMETHYLAMINE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER RADIOTHERAPY; DRUG SYNTHESIS; GLIOBLASTOMA; HEP 2 CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; LYSOSOME; NEUTRON CAPTURE THERAPY; SUBSTITUTION REACTION; X RAY ANALYSIS;

BORON COMPOUNDS; BORON NEUTRON CAPTURE THERAPY; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; HUMANS; LYSOSOMES; METHYLAMINES; MOLECULAR STRUCTURE; PHOSPHONIC ACIDS; PORPHYRINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 40949160572     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.12.020     Document Type: Article

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