Boron neutron capture therapy in the treatment of locally recurred head-and-neck cancer: Final analysis of a phase I/II trial

International Journal of Radiation Oncology Biology Physics

Volumn 82, Issue 1, 2012, Pages

  Kankaanranta, Leena ^a   Seppälä, Tiina ^b,c   Koivunoro, Hanna ^b,c   Saarilahti, Kauko ^a   Atula, Timo ^a   Collan, Juhani ^a   Salli, Eero ^a   Kortesniemi, Mika ^a   Uusi Simola, Jouni ^a,b   Välimäki, Petteri ^b,c   Mäkitie, Antti ^a   Seppänen, Marko ^d   Minn, Heikki ^d   Revitzer, Hannu ^e   Kouri, Mauri ^a   Kotiluoto, Petri ^f   Seren, Tom ^f   Auterinen, Iiro ^f   Savolainen, Sauli ^a,b   Joensuu, Heikki ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c Boneca Corporation   (Finland)

^d TURKU UNIVERSITY HOSPITAL   (Finland)

^e AALTO UNIVERSITY   (Finland)

^f VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

Author keywords

Boron neutron capture therapy; Boronophenylalanine; Head and neck cancer; Radiotherapy

Indexed keywords

ADVERSE EFFECT; BORON NEUTRON CAPTURE THERAPY; BORONOPHENYLALANINE; CANCER RECURRENCE; COMMON TERMINOLOGY CRITERIA; CONFIDENCE INTERVAL; EVALUATION CRITERIA; HEAD-AND-NECK CANCER; LOCOREGIONAL RECURRENCE; MUCOSITIS; NATIONAL CANCER INSTITUTE; OSTEORADIONECROSIS; OVERALL SURVIVAL; PHASE I; PHOTON IRRADIATION; PHOTON RADIATION; PROGRESSION FREE SURVIVAL; SOFT TISSUE; SOLID TUMORS; TUMOR GROWTH; TUMOR RESPONSE; XEROSTOMIA;

BORON; BORON COMPOUNDS; CHEMOTHERAPY; DISEASES; NEUTRON IRRADIATION; NEUTRONS; PHOTONS; TUMORS;

RADIOTHERAPY;

ANTINEOPLASTIC AGENT; BORON DERIVATIVE; BORONPHENYLALANINE; FLUOROBORONPHENYLALANINE F 18; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ADULT; AGED; ALOPECIA; ARTICLE; BONE NECROSIS; BRUNEI DARUSSALAM; BURN; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER PAIN; CANCER RADIOTHERAPY; CANCER SURGERY; CANCER SURVIVAL; CATARACT; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; DERMATITIS; DIPLOPIA; DRY EYE; DYSGEUSIA; DYSPHAGIA; EYE DISEASE; FATIGUE; FEMALE; FIBROSIS; FOLLOW UP; HEAD AND NECK CARCINOMA; HEAD AND NECK SARCOMA; HEARING IMPAIRMENT; HUMAN; KERATITIS; MALE; MOUTH PAIN; MUCOSA INFLAMMATION; MULTIPLE CYCLE TREATMENT; MYOSITIS; NAUSEA; NEUTRON CAPTURE THERAPY; OCULAR SURFACE DISEASE; OLIGURIA; OPEN STUDY; OTITIS; OVERALL SURVIVAL; PAHRYNGEAL MUCOSITIS; PERIODONTAL DISEASE; PHARYNGITIS; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PHOTON THERAPY; PNEUMONIA; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; PROSPECTIVE STUDY; RADIATION DERMATITIS; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RADIATION PNEUMONIA; RADIATION SAFETY; RECURRENT CANCER; SARCOMA; SEPTICEMIA; SKIN INDURATION; TISSUE NECROSIS; TREATMENT RESPONSE; TRISMUS; TUMOR PAIN; ULCER; VOMITING; XEROSTOMIA;

ADULT; AGED; BORON COMPOUNDS; BORON NEUTRON CAPTURE THERAPY; CARCINOMA, ADENOID CYSTIC; CARCINOMA, SQUAMOUS CELL; CONFIDENCE INTERVALS; DISEASE-FREE SURVIVAL; FATIGUE; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; MALE; MIDDLE AGED; MOUTH DISEASES; MUCOSITIS; NEOPLASM RECURRENCE, LOCAL; OSTEORADIONECROSIS; PAIN; PHENYLALANINE; PROSPECTIVE STUDIES; RADIOTHERAPY DOSAGE; SARCOMA; XEROSTOMIA;

EID: 81155162233     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2010.09.057     Document Type: Article

References (32)

1. L.Y. Wong, W.I. Wei, and L.K. Lam Salvage of recurrent head and neck squamous cell carcinoma after primary curative surgery Head Neck 25 2003 953 959
2. H. Gilbert, and A.R. Kagan Recurrence patterns in squamous cell carcinoma of the oral cavity, pharynx, and larynx J Surg Oncol 6 1974 357 380
3. H.K. Tan, R. Giger, and A. Auperin Salvage surgery after concomitant chemoradiation in head and neck squamous cell carcinomas - Stratification for postsalvage survival Head Neck 32 2010 139 147
4. T. Tanvetyanon, T. Padhya, and J. McCaffrey Prognostic factors for survival after salvage reirradiation of head and neck cancer J Clin Oncol 27 2009 1983 1991
5. S.A. Spencer, J. Harris, and R.H. Wheeler RTOG 96-10: Reirradiation with concurrent hydroxyurea and 5-fluorouracil in patients with squamous cell cancer of the head and neck Int J Radiat Oncol Biol Phys 51 2001 1299 1304
6. F. Janot, D. de Raucourt, and E. Benhamou Randomized trial of postoperative reirradiation combined with chemotherapy after salvage surgery compared with salvage surgery alone in head and neck carcinoma J Clin Oncol 26 2008 5518 5523
7. J.K. Salama, E.E. Vokes, and S.J. Chmura Long-term outcome of concurrent chemotherapy and reirradiation for recurrent and second primary head-and-neck squamous cell carcinoma Int J Radiat Oncol Biol Phys 64 2006 382 391
8. R. De Crevoisier, J. Bourhis, and C. Domenge Full-dose reirradiation for unresectable head and neck carcinoma: Experience at the Gustave-Roussy Institute in a series of 169 patients J Clin Oncol 16 1998 3556 3562
9. R.F. Barth, J.A. Coderre, and G.H. Vicente Boron neutron capture therapy of cancer: Current status and future prospects Clin Cancer Res 11 2005 3987 4002
10. A. Wittig, L. Collette, and K. Appelman EORTC trial 11001: Distribution of two 10B-compounds in patients with squamous cell carcinoma of head and neck, a translational research/phase 1 trial J Cell Mol Med 13 2009 1653 1665
11. I. Kato, Y. Fujita, and A. Maruhashi Effectiveness of boron neutron capture therapy for recurrent head and neck malignancies Appl Radiat Isot 67 Suppl. 2009 S37 S42
12. Y. Kimura, Y. Ariyoshi, and M. Shimahara Boron neutron capture therapy for recurrent oral cancer and metastasis of cervical lymph node Appl Radiat Isot 67 Suppl. 2009 S47 S49
13. N. Fuwa, M. Suzuki, and Y. Sakurai Treatment results of boron neutron capture therapy using intra-arterial administration of boron compounds for recurrent head and neck cancer Br J Radiol 81 2008 749 752
14. M. Kouri, L. Kankaanranta, and T. Seppälä Undifferentiated sinonasal carcinoma may respond to single-fraction boron neutron capture therapy Radiother Oncol 72 2004 83 85
15. T. Aihara, J. Hiratsuka, and N. Morita First clinical case of boron neutron capture therapy for head and neck malignant Head and Neck 28 2006 850 855
16. L. Kankaanranta, T. Seppälä, and H. Koivunoro Boron neutron capture therapy in the treatment of locally recurred head and neck cancer Int J Radiat Oncol Biol Phys 69 2007 475 482
17. K. Havu-Auren, J. Kiiski, and K. Lehtiö Uptake of 4-borono-2-[(18)F]fluoro-L-phenylalanine in sporadic and neurofibromatosis 2-related schwannoma and meningioma studied with PET Eur J Nucl Med Mol Imaging 34 2007 87 92
18. D.W. Nigg Computational dosimetry and treatment planning considerations for neutron capture therapy J Neurooncol 62 2003 75 86
19. International Commission on Radiation Units & Measurements ICRU report 46: Photon, electron, proton, and neutron interaction data for body tissues 1992 International Commission on Radiation Units & Measurements Bethesda, MD
20. H. Joensuu, L. Kankaanranta, and T. Seppälä Boron neutron capture therapy of brain tumors: Clinical trials at the Finnish facility using boronophenylalanine J Neurooncol 62 2003 123 134
21. J.A. Coderre, and G.M. Morris Review: The radiation biology of boron neutron capture therapy Rad Res 151 1999 1 18
22. F.J. Wheeler, D.W. Nigg, and J. Capala Boron neutron capture therapy (BNCT): Implications of neutron beam and boron compound characteristics Med Phys 26 1999 1237 1244
23. P.M. Ryynänen, M. Kortesniemi, and J.A. Coderre Models for estimation of the (10)B concentration after BPA-fructose complex infusion in patients during epithermal neutron irradiation in BNCT Int J Radiat Oncol Biol Phys 48 2000 1145 1154
24. P. Therasse, S.G. Arbuck, and E.A. Eisenhauer New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada J Natl Cancer Inst 92 2000 205 216
25. J.P. Pignon, A. le Maître, and E. Maillard Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 93 randomised trials and 17,346 patients Radiother Oncol 92 2009 4 14
26. J.B. Vermorken, R. Mesia, and F. Rivera Platinum-based chemotherapy plus cetuximab in head and neck cancer N Engl J Med 359 2008 1116 1127
27. M. Suzuki, Y. Sakurai, and K. Nagata Impact of intra-arterial administration of boron compounds on dose-volume histograms in boron neutron capture therapy for recurrent head-and-neck tumors Int J Radiat Oncol Biol Phys 66 2006 1523 1527
28. Y. Nakagawa, K. Pooh, and T. Kobayashi Clinical review of the Japanese experience with boron neutron capture therapy and a proposed strategy using epithermal neutron beams J Neurooncol 62 2003 87 99
29. A.Z. Diaz Assessment of the results from the phase I/II boron neutron capture therapy trials at the Brookhaven National Laboratory from a clinician's point of view J Neurooncol 62 2003 101 109
30. P.M. Busse, O.K. Harling, and M.R. Palmer A critical examination of the results from the Harvard-MIT NCT program phase I clinical trial of neutron capture therapy for intracranial disease J Neurooncol 62 2003 111 121
31. R. Henriksson, J. Capala, and A. Michanek Boron neutron capture therapy (BNCT) for glioblastoma multiforme: A phase II study evaluating a prolonged high-dose of boronophenylalanine (BPA) Radiother Oncol 88 2008 183 191
32. S. Miyatake, S. Kawabata, and K. Yokoyama Survival benefit of boron neutron capture therapy for recurrent malignant gliomas J Neurooncol 91 2009 199 206