Proton-coupled organic cation antiporter-mediated uptake of apomorphine enantiomers in human brain capillary endothelial cell line hCMEC/D3

Biological and Pharmaceutical Bulletin

Volumn 37, Issue 2, 2014, Pages 286-291

  Okura, Takashi ^a   Higuchi, Kei ^a   Kitamura, Atsushi ^a   Deguchi, Yoshiharu ^a  

^a TEIKYO UNIVERSITY   (Japan)

Author keywords

Apomorphine; Blood brain barrier; hCMEC D3 cell; Proton coupled organic cation antiporter

Indexed keywords

ANTIPORTERS; APOMORPHINE; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; CATIONS; CELL LINE; DOPAMINE AGONISTS; ENDOTHELIAL CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; MEMBRANE POTENTIALS; ORGANIC CATION TRANSPORT PROTEINS; PROTONS; SODIUM; STEREOISOMERISM;

EID: 84893260561     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b13-00773     Document Type: Article

References (17)

1. Sam E, Sarre S, Michotte Y, Verbeke N. Distribution of apomorphine enantiomers in plasma, brain tissue and striatal extracellular fluid. Eur. J. Pharmacol., 329, 9-15 (1997).
2. Weksler BB, Subileau EA, Perrière N, Charneau P, Holloway K, Leveque M, Tricoire-Leignel H, Nicotra A, Bourdoulous S, Turowski P, Male DK, Roux F, Greenwood J, Romero IA, Couraud PO. Blood-brain barrier-specific properties of a human adult brain endothelial cell line. FASEB J., 19, 1872-1874 (2005).
3. Weksler B, Romero IA, Couraud PO. The hCMEC/D3 cell line as a model of the human blood brain barrier. Fluids and Barriers of the CNS, 10, 16 (2013).
4. +/OC) antiporter in human brain capillary endothelial cell line hCMEC/D3, a human blood-brain barrier model. Fluids and Barriers of the CNS, 10, 8 (2013).
5. Boström E, Simonsson US, Hammarlund-Udenaes M. In vivo blood-brain barrier transport of oxycodone in the rat: indications for active influx and implications for pharmacokinetics/pharmacodynamics. Drug Metab. Dispos., 34, 1624-1631 (2006).
6. Okura T, Hattori A, Takano Y, Sato T, Hammarlund-Udenaes M, Terasaki T, Deguchi Y. Involvement of the pyrilamine transporter, a putative organic cation transporter, in blood-brain barrier transport of oxycodone. Drug Metab. Dispos., 36, 2005-2013 (2008).
7. Sadiq MW, Borgs A, Okura T, Shimomura K, Kato S, Deguchi Y, Jansson B, Björkman S, Terasaki T, Hammarlund-Udenaes M. Diphenhydramine active uptake at the blood-brain barrier and its interaction with oxycodone in vitro and in vivo. J. Pharm. Sci., 100, 3912-3923 (2011).
8. Okura T, Kato S, Deguchi Y. Functional expression of organic cation/carnitine transporter 2 (OCTN2/SLC22A5) in human brain capillary endothelial cell line hCMEC/D3, a human blood-brain barrier model. Drug Metab. Pharmacokinet., 2013, in press.
9. Kuwayama K, Inoue H, Kanamori T, Tsujikawa K, Miyaguchi H, Iwata Y, Miyauchi S, Kamo N, Kishi T. Uptake of 3,4-methylenedioxymethamphetamine and its related compounds by a protoncoupled transport system in Caco-2 cells. Biochim. Biophys. Acta, 1778, 42-50 (2008).
10. + antiporter that interacts with addictive drugs. J. Cereb. Blood Flow Metab., 29, 1293-1304 (2009).
11. Kubo Y, Shimizu Y, Kusagawa Y, Akanuma S, Hosoya K. Propranolol transport across the inner blood-retinal barrier: potential involvement of a novel organic cation transporter. J. Pharm. Sci., 102, 3332-3342 (2013).
12. Szabo Z, Ravert HT, Gözükara I, Geckle W, Seki C, Sostre S, Peller P, Monsein L, Natarajan TK, Links JM, Wong DF, Dannals RF, Wagner HN Jr. Noncompartmental and compartmental modeling of the kinetics of carbon-11 labeled pyrilamine in the human brain. Synapse, 15, 263-275 (1993).
13. Okura T, Ito R, Ishiguro N, Tamai I, Deguchi Y. Blood-brain barrier transport of pramipexole, a dopamine D2 agonist. Life Sci., 80, 1564-1571 (2007).
14. Mizuuchi H, Katsura T, Ashida K, Hashimoto Y, Inui KI. Diphenhydramine transport by pH-dependent tertiary amine transport system in Caco-2 cells. Am. J. Physiol. Gastrointest. Liver Physiol., 278, G563-G569 (2000).
15. Cisternino S, Chapy H, André P, Smirnova M, Debray M, Scherrmann JM. Coexistence of passive and proton antiporter-mediated processes in nicotine transport at the mouse blood-brain barrier. AAPS J., 15, 299-307 (2013).
16. Tega Y, Akanuma S, Kubo Y, Terasaki T, Hosoya K. Blood-to-brain influx transport of nicotine at the rat blood-brain barrier: involvement of a pyrilamine-sensitive organic cation transport process. Neurochem. Int., 62, 173-181 (2013).
17. Armstrong J, Barlow RB. The ionization of phenolic amines, including apomorphine, dopamine and catecholamines and an assessment of zwitterion constants. Br. J. Pharmacol., 57, 501-516 (1976).