Neuron-specific (Pro)renin receptor knockout prevents the development of salt-sensitive hypertension

Hypertension

Volumn 63, Issue 2, 2014, Pages 316-323

  Li, Wencheng ^a   Peng, Hua ^b   Mehaffey, Eamonn P ^a   Kimball, Christie D ^b   Grobe, Justin L ^a   Van Gool, Jeanette M G ^c,d   Sullivan, Michelle N ^b   Earley, Scott ^a   Jan Danser, A H ^d   Ichihara, Atsuhiro ^e   Feng, Yumei ^a,b  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF IOWA   (United States)

^d ERASMUS MEDICAL CENTER   (Netherlands)

^e TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

(pro)renin receptor; angiotensin II; central nervous system; hypertension

Indexed keywords

ANGIOTENSIN II; LOSARTAN; PRORENIN; PRORENIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DEOXYCORTICOSTERONE-SALT INDUCED HYPERTENSION; FEMALE; GENE INACTIVATION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PLASMA RENIN ACTIVITY; PRESSOR RESPONSE; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYMPATHETIC TONE; TELEMETRY; VASOMOTOR REFLEX; WILD TYPE;

EID: 84892940481     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.113.02041     Document Type: Article

References (37)

1. Ma R, Schultz HD, Wang W. Chronic central infusion of ANG II potentiates cardiac sympathetic afferent reflex in dogs. Am J Physiol. 1999;277(1 Pt 2):H15-H22.
2. Davisson RL, Yang G, Beltz TG, Cassell MD, Johnson AK, Sigmund CD. The brain renin-angiotensin system contributes to the hypertension in mice containing both the human renin and human angiotensinogen transgenes. Circ Res. 1998;83:1047-1058.
3. Schelling P, Hutchinson JS, Ganten U, Sponer G, Ganten D. Impermeability of the blood-cerebrospinal fluid barrier for angiotensin II in rats. Clin Sci Mol Med Suppl. 1976;3:399s-402s.
4. Volicer L, Loew CG. Penetration of angiotensin II into the brain. Neuropharmacology. 1971;10:631-636.
5. Trolliet MR, Phillips MI. The effect of chronic bilateral nephrectomy on plasma and brain angiotensin. J Hypertens. 1992;10:29-36.
6. Bader M, Ganten D. It's renin in the brain: transgenic animals elucidate the brain renin angiotensin system. Circ Res. 2002;90:8-10.
7. Lavoie JL, Cassell MD, Gross KW, Sigmund CD. Localization of renin expressing cells in the brain, by use of a REN-eGFP transgenic model. Physiol Genomics. 2004;16:240-246.
8. Hirose S, Naruse M, Ohtsuki K, Inagami T. Totally inactive renin zymogen and different forms of active renin in hog brain tissues. J Biol Chem. 1981;256:5572-5576.
9. Contrepas A, Walker J, Koulakoff A, Franek KJ, Qadri F, Giaume C, Corvol P, Schwartz CE, Nguyen G. A role of the (pro)renin receptor in neuronal cell differentiation. Am J Physiol Regul Integr Comp Physiol. 2009;297:R250-R257.
10. Shan Z, Cuadra AE, Sumners C, Raizada MK. Characterization of a functional (pro)renin receptor in rat brain neurons. Exp Physiol. 2008;93:701-708.
11. Nguyen G, Delarue F, Burcklé C, Bouzhir L, Giller T, Sraer JD. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest. 2002;109:1417-1427.
12. Laragh JH. Biochemical profiling and the natural history of hypertensive diseases: low-renin essential hypertension, a benign condition. Circulation. 1971;44:971-974.
13. Makrides SC, Mulinari R, Zannis VI, Gavras H. Regulation of renin gene expression in hypertensive rats. Hypertension. 1988;12:405-410.
14. Michel B, Grima M, Stephan D, Coquard C, Welsch C, Barthelmebs M, Imbs JL. Plasma renin activity and changes in tissue angiotensin converting enzyme. J Hypertens. 1994;12:577-584.
15. Itaya Y, Suzuki H, Matsukawa S, Kondo K, Saruta T. Central renin-angiotensin system and the pathogenesis of DOCA-salt hypertension in rats. Am J Physiol. 1986;251(2 Pt 2):H261-H268.
16. Kubo T, Yamaguchi H, Tsujimura M, Hagiwara Y, Fukumori R. Blockade of angiotensin receptors in the anterior hypothalamic preoptic area lowers blood pressure in DOCA-salt hypertensive rats. Hypertens Res. 2000;23:109-118.
17. Li W, Peng H, Cao T, Sato R, McDaniels SJ, Kobori H, Navar LG, Feng Y. Brain-targeted (pro)renin receptor knockdown attenuates angiotensin II-dependent hypertension. Hypertension. 2012;59:1188-1194.
18. Shan Z, Shi P, Cuadra AE, Dong Y, Lamont GJ, Li Q, Seth DM, Navar LG, Katovich MJ, Sumners C, Raizada MK. Involvement of the brain (pro)renin receptor in cardiovascular homeostasis. Circ Res. 2010;107:934-938.
19. Kinouchi K, Ichihara A, Sano M, Sun-Wada GH, Wada Y, Kurauchi-Mito A, Bokuda K, Narita T, Oshima Y, Sakoda M, Tamai Y, Sato H, Fukuda K, Itoh H. The (pro)renin receptor/ATP6AP2 is essential for vacuolar H+-ATPase assembly in murine cardiomyocytes. Circ Res. 2010;107:30-34.
20. Hirasawa M, Cho A, Sreenath T, Sauer B, Julien JP, Kulkarni AB. Neuronspecific expression of Cre recombinase during the late phase of brain development. Neurosci Res. 2001;40:125-132.
21. Shiotani M, Hano T, Baba A, Ueda E, Nishio I, Masuyama Y. Altered renin release from isolated superfused rat glomeruli in DOCA-salt hypertensive rats. Clin Exp Hypertens A. 1991;13:1223-1232.
22. Lind RW, Swanson LW, Ganten D. Angiotensin II immunoreactivity in the neural afferents and efferents of the subfornical organ of the rat. Brain Res. 1984;321:209-215.
23. Lind RW, Swanson LW, Ganten D. Organization of angiotensin II immunoreactive cells and fibers in the rat central nervous system. An immunohistochemical study. Neuroendocrinology. 1985;40:2-24.
24. Oshima Y, Kinouchi K, Ichihara A, Sakoda M, Kurauchi-Mito A, Bokuda K, Narita T, Kurosawa H, Sun-Wada GH, Wada Y, Yamada T, Takemoto M, Saleem MA, Quaggin SE, Itoh H. Prorenin receptor is essential for normal podocyte structure and function. J Am Soc Nephrol. 2011;22:2203-2212.
25. Song R, Preston G, Ichihara A, Yosypiv IV. Deletion of the prorenin receptor from the ureteric bud causes renal hypodysplasia. PLoS One. 2013;8:e63835.
26. Finlay BL, Darlington RB. Linked regularities in the development and evolution of mammalian brains. Science. 1995;268:1578-1584.
27. Li W, Peng H, Seth DM, Feng Y. The prorenin and (pro)renin receptor: new players in the brain renin-angiotensin system? Int J Hypertens. 2012;2012:290635.
28. Methot D, Silversides DW, Reudelhuber TL. In vivo enzymatic assay reveals catalytic activity of the human renin precursor in tissues. Circ Res. 1999;84:1067-1072.
29. Castrop H, Höcherl K, Kurtz A, Schweda F, Todorov V, Wagner C. Physiology of kidney renin. Physiol Rev. 2010;90:607-673.
30. Batenburg WW, Krop M, Garrelds IM, de Vries R, de Bruin RJA, Burckle CA, Muller DN, Bader M, Nguyen G, Danser AHJ. Prorenin is the endogenous agonist of the (pro)renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor. J Hypertens. 2007;25:2441-2453.
31. Ichihara A, Kaneshiro Y, Takemitsu T, Sakoda M, Suzuki F, Nakagawa T, Nishiyama A, Inagami T, Hayashi M. Nonproteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension. Hypertension. 2006;47:894-900.
32. Huang C, Yoshimoto M, Miki K, Johns EJ. The contribution of brain angiotensin II to the baroreflex regulation of renal sympathetic nerve activity in conscious normotensive and hypertensive rats. J Physiol. 2006;574(Pt 2):597-604.
33. Crofton JT, Rockhold RW, Share L, Wang BC, Horovitz ZP, Manning M, Sawyer WH. Effect of intracerebroventricular captopril on vasopressin and blood pressure in spontaneously hypertensive rats. Hypertension. 1981;3(6 Pt 2):II-71.
34. Biswas KB, Nabi AN, Arai Y, Nakagawa T, Ebihara A, Ichihara A, Inagami T, Suzuki F. Qualitative and quantitative analyses of (pro)renin receptor in the medium of cultured human umbilical vein endothelial cells. Hypertens Res. 2011;34:735-739.
35. Greco CM, Camera M, Facchinetti L, Brambilla M, Pellegrino S, Gelmi ML, Tremoli E, Corsini A, Ferri N. Chemotactic effect of prorenin on human aortic smooth muscle cells: a novel function of the (pro)renin receptor. Cardiovasc Res. 2012;95:366-374.
36. Gavras H, Brunner HR, Laragh JH, Vaughan ED Jr, Koss M, Cote LJ, Gavras I. Malignant hypertension resulting from deoxycorticosterone acetate and salt excess: role of renin and sodium in vascular changes. Circ Res. 1975;36:300-309.
37. Siragy HM, Huang J. Renal (pro)renin receptor upregulation in diabetic rats through enhanced angiotensin AT1 receptor and NADPH oxidase activity. Exp Physiol. 2008;93:709-714.