Aldosterone acting through the central nervous system sensitizes angiotensin II-induced hypertension

Hypertension

Volumn 60, Issue 4, 2012, Pages 1023-1030

  Xue, Baojian ^a   Zhang, Zhongming ^a   Roncari, Camila F ^a   Guo, Fang ^a   Johnson, Alan Kim ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

aldosterone; angiotensin II; blood pressure; brain renin angiotensin aldosterone system expression; sensitization

Indexed keywords

ALDOSTERONE; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN II; ANGIOTENSINOGEN; CALCIUM; DIPEPTIDYL CARBOXYPEPTIDASE; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; BRAIN REGION; BRAIN TISSUE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; FOREBRAIN; GENE EXPRESSION; HEART RATE; HYPERTENSION; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; IMMUNOREACTIVITY; MALE; MEAN ARTERIAL PRESSURE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SENSITIZATION; SUBFORNICAL ORGAN;

ALDOSTERONE; ANGIOTENSIN II; ANIMALS; BLOOD PRESSURE; CELLS, CULTURED; HYPERTENSION; HYPOTHALAMUS; MALE; NEURONS; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RATS; RATS, SPRAGUE-DAWLEY; RENIN-ANGIOTENSIN SYSTEM; TELEMETRY;

EID: 84866556068     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.112.196576     Document Type: Article

References (35)

1. Huang BS, Leenen FH. Mineralocorticoid actions in the brain and hypertension. Curr Hypertens Rep. 2011;13:214-220.
2. Min LJ, Mogi M, Iwai M, Horiuchi M. Signaling mechanisms of angioten-sin II in regulating vascular senescence. Ageing Res Rev. 2009;8:113-121.
3. Xue B, Beltz TG, Yu Y, Guo F, Gomez-Sanchez CE, Hay M, Johnson AK. Central interactions of aldosterone and angiotensin II in aldosterone-and angiotensin II-induced hypertension. Am J Physiol Heart Circ Physiol. 2011;300:H555-H564.
4. Huang BS, Ahmadi S, Ahmad M, White RA, Leenen FH. Central neuronal activation and pressor responses induced by circulating ANG II: role of the brain aldosterone-"ouabain" pathway. Am J Physiol Heart Circ Physiol. 2010;299:H422-H430.
5. Zhang ZH, Yu Y, Kang YM, Wei SG, Felder RB. Aldosterone acts centrally to increase brain renin-angiotensin system activity and oxidative stress in normal rats. Am J Physiol Heart Circ Physiol. 2008;294:H1067-H1074.
6. Huang BS, White RA, Jeng AY, Leenen FH. Role of central nervous system aldosterone synthase and mineralocorticoid receptors in salt-induced hypertension in Dahl salt-sensitive rats. Am J Physiol Regul Integr Comp Physiol. 2009;296:R994-R1000.
7. Yu Y, Wei SG, Zhang ZH, Gomez-Sanchez E, Weiss RM, Felder RB. Does aldosterone upregulate the brain renin-angiotensin system in rats with heart failure? Hypertension. 2008;51:727-733.
8. Sakai RR, Fine WB, Epstein AN, Frankmann SP. Salt appetite is enhanced by one prior episode of sodium depletion in the rat. Behav Neurosci. 1987;101:724-731.
9. Moellenhoff E, Blume A, Culman J, Chatterjee B, Herdegen T, Lebrun CJ, Unger T. Effect of repetitive icv injections of ANG II on c-Fos and AT(1)-receptor expression in the rat brain. Am J Physiol Regul Integr Comp Physiol. 2001;280:R1095-R1104.
10. Zhang DM, Stellar E, Epstein AN. Together intracranial angiotensin and systemic mineralocorticoid produce avidity for salt in the rat. Physiol Behav. 1984;32:677-681.
11. Thornton SN, Nicolaïdis S. Long-term mineralocorticoid-induced changes in rat neuron properties plus interaction of aldosterone and ANG II. Am J Physiol. 1994;266(2 pt 2):R564-R571.
12. Xue B, Zhang Z, Johnson RF, Johnson AK. Sensitization of slow pressor angiotensin II (Ang II)-initiated hypertension: induction of sensitization by prior Ang II treatment. Hypertension. 2012;59:459-466.
13. Johnson AK, Gross PM. Sensory circumventricular organs and brain homeostatic pathways. FASEB J. 1993;7:678-686.
14. Gomez-Sanchez EP, Gomez-Sanchez CE. Central regulation of blood pressure by the mineralocorticoid receptor. Mol Cell Endocrinol. 2012;350:289-298.
15. Lenkei Z, Palkovits M, Corvol P, Llorens-Cortes C. Distribution of angio-tensin type-1 receptor messenger RNA expression in the adult rat brain. Neuroscience. 1998;82:827-841.
16. Wehling M, Neylon CB, Fullerton M, Bobik A, Funder JW. Nongenomic effects of aldosterone on intracellular Ca2+ in vascular smooth muscle cells. Circ Res. 1995;76:973-979.
17. Gomez-Sanchez EP, Ahmad N, Romero DG, Gomez-Sanchez CE. Is aldo-sterone synthesized within the rat brain? Am J Physiol Endocrinol Metab. 2005;288:E342-E346.
18. Lavoie JL, Sigmund CD. Minireview: overview of the renin-angio-tensin system-an endocrine and paracrine system. Endocrinology. 2003;144:2179-2183.
19. Bohlender J, Ménard J, Ganten D, Luft FC. Angiotensinogen concentrations and renin clearance: implications for blood pressure regulation. Hypertension. 2000;35:780-786.
20. Sakai K, Agassandian K, Morimoto S, Sinnayah P, Cassell MD, Davisson RL, Sigmund CD. Local production of angiotensin II in the subfornical organ causes elevated drinking. J Clin Invest. 2007;117:1088-1095.
21. Michel F, Ambroisine ML, Duriez M, Delcayre C, Levy BI, Silvestre JS. Aldosterone enhances ischemia-induced neovascularization through angiotensin II-dependent pathway. Circulation. 2004;109:1933-1937.
22. Lea WB, Kwak ES, Luther JM, Fowler SM, Wang Z, Ma J, Fogo AB, Brown NJ. Aldosterone antagonism or synthase inhibition reduces endorgan damage induced by treatment with angiotensin and high salt. Kidney Int. 2009;75:936-944.
23. Ye P, Kenyon CJ, Mackenzie SM, Nichol K, Seckl JR, Fraser R, Connell JM, Davies E. Effects of ACTH, dexamethasone, and adrenalectomy on 11beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) gene expression in the rat central nervous system. J Endocrinol. 2008;196:305-311.
24. Xu P, Sriramula S, Lazartigues E. ACE2/ANG-(1-7)/Mas pathway in the brain: the axis of good. Am J Physiol Regul Integr Comp Physiol. 2011;300:R804-R817.
25. Xia H, Feng Y, Obr TD, Hickman PJ, Lazartigues E. Angiotensin II type 1 receptor-mediated reduction of angiotensin-converting enzyme 2 activity in the brain impairs barorefex function in hypertensive mice. Hypertension. 2009;53:210-216.
26. Yamamuro M, Yoshimura M, Nakayama M, Abe K, Sumida H, Sugiyama S, Saito Y, Nakao K, Yasue H, Ogawa H. Aldosterone, but not angiotensin II, reduces angiotensin converting enzyme 2 gene expression levels in cultured neonatal rat cardiomyocytes. Circ J. 2008;72:1346-1350.
27. Fukuda S, Horimai C, Harada K, Wakamatsu T, Fukasawa H, Muto S, Itai A, Hayashi M. Aldosterone-induced kidney injury is mediated by NF?B activation. Clin Exp Nephrol. 2011;15:41-49.
28. Keidar S, Gamliel-Lazarovich A, Kaplan M, Pavlotzky E, Hamoud S, Hayek T, Karry R, Abassi Z. Mineralocorticoid receptor blocker increases angiotensin-converting enzyme 2 activity in congestive heart failure patients. Circ Res. 2005;97:946-953.
29. Gomes da Silva AQ, Sousa dos Santos RA, PelikyFontes MA. Blockade of endogenous angiotensin-(1-7) in the hypothalamic paraventricular nucleus reduces renal sympathetic tone. Hypertension. 2005;46:341-348.
30. Feng Y, Xia H, Cai Y, Halabi CM, Becker LK, Santos RA, Speth RC, Sigmund CD, Lazartigues E. Brain-selective overexpression of human Angiotensin- converting enzyme type 2 attenuates neurogenic hypertension. Circ Res. 2010;106:373-382.
31. Masaki H, Kurihara T, Yamaki A, Inomata N, Nozawa Y, Mori Y, Murasawa S, Kizima K, Maruyama K, Horiuchi M, Dzau VJ, Takahashi H, Iwasaka T, Inada M, Matsubara H. Cardiac-specifc overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pres-sor and chronotropic effects. J Clin Invest. 1998;101:527-535.
32. Gao J, Zhang H, Le KD, Chao J, Gao L. Activation of central angiotensin type 2 receptors suppresses norepinephrine excretion and blood pressure in conscious rats. Am J Hypertens. 2011;24:724-730.
33. Gao L, Wang W, Wang W, Li H, Sumners C, Zucker IH. Effects of angio-tensin type 2 receptor overexpression in the rostral ventrolateral medulla on blood pressure and urine excretion in normal rats. Hypertension. 2008;51:521-527.
34. Yatabe J, Yoneda M, Yatabe MS, Watanabe T, Felder RA, Jose PA, Sanada H. Angiotensin III stimulates aldosterone secretion from adrenal gland partially via angiotensin II type 2 receptor but not angiotensin II type 1 receptor. Endocrinology. 2011;152:1582-1588.
35. Tanabe A, Naruse M, Naruse K, Yoshimoto T, Tanaka M, Mishina N, Imaki T, Sugaya K, Miyazaki H, Demura H. Angiotensin II receptor subtype in human adrenal glands [in Japanese]. Nippon Rinsho. 1999;57:1042-1048.