PVN adenovirus-siRNA injections silencing either NOX2 or NOX4 attenuate aldosterone/NaCl-induced hypertension in mice

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 302, Issue 3, 2012, Pages

  Xue, Baojian ^a,b   Beltz, Terry G ^a   Johnson, Ralph F ^a   Guo, Fang ^a   Hay, Meredith ^c   Johnson, Alan Kim ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Blood pressure; Paraventricular nucleus; Reactive oxygen species; Small interfering ribonucleic acid

Indexed keywords

ADENOVIRUS VECTOR; ALDOSTERONE; ENHANCED GREEN FLUORESCENT PROTEIN; HEXAMETHONIUM; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SMALL INTERFERING RNA; SODIUM CHLORIDE; SUPEROXIDE; WATER;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; GANGLION BLOCK; GENE EXPRESSION REGULATION; GENE SILENCING; HYPERTENSION; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; MALE; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; OSMOTIC PUMP; PRIORITY JOURNAL; SALT INTAKE; SYMPATHETIC TONE; VIRAL GENE DELIVERY SYSTEM; WESTERN BLOTTING;

ADENOVIRIDAE; ALDOSTERONE; ANIMALS; AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE; FEMALE; GENE THERAPY; HYPERTENSION; INFUSION PUMPS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NADPH OXIDASE; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SODIUM CHLORIDE;

EID: 84863049043     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00873.2011     Document Type: Article

References (35)

1. Bai Y, Jabbari B, Ye S, Campese VM, Vaziri ND. Regional expression of NAD(P)H oxidase and superoxide dismutase in the brain of rats with neurogenic hypertension. Am J Nephrol 29: 483-492, 2009.
2. Bayorh MA, Rollins-Hairston A, Adiyiah J, Lyn D, Eatman D. Epler-enone suppresses aldosterone/salt-induced expression of NOX-4. J Renin Angiotensin Aldosterone Syst 12: 195-201, 2011.
3. Brandes RP, Kreuzer J. Vascular NADPH oxidases: molecular mechanisms of activation. Cardiovasc Res 65: 16-27, 2005.
4. Dampney RA. Functional organization of central pathways regulating the cardiovascular system. Physiol Rev 74: 323-364, 1994.
5. Dworakowski R, Anilkumar N, Zhang M, Shah AM. Redox signalling involving NADPH oxidase-derived reactive oxygen species. Biochem Soc Trans 34: 960-964, 2006.
6. Ellmark SH, Dusting GJ, Fui MN, Guzzo-Pernell N, Drummond GR. The contribution of Nox4 to NADPH oxidase activity in mouse vascular smooth muscle. Cardiovasc Res 65: 495-504, 2005.
7. Fluharty SJ, Epstein AN. Sodium appetite elicited by intracerebroven-tricular infusion of angiotensin II in the rat: II. Synergistic interaction with systemic mineralocorticoids. Behav Neurosci 97: 746-758, 1983.
8. Funder JW, Mihailidou AS. Aldosterone and mineralocorticoid receptors: clinical studies and basic biology. Mol Cell Endocrinol 301: 2-6, 2009.
9. Funder JW. Aldosterone, mineralocorticoid receptors and vascular inflammation. Mol Cell Endocrinol 217: 263-269, 2004.
10. Geerling JC, Loewy AD. Aldosterone in the brain. Am J Physiol Renal Physiol 297: F559-F576, 2009.
11. Gilbert KC, Brown NJ. Aldosterone and inflammation. Curr Opin Endocrinol Diabetes Obes 17: 199-204, 2010.
12. Griendling KK. Novel NAD(P)H oxidases in the cardiovascular system. Heart 90: 491-493, 2004.
13. Haque MZ, Majid DS. High salt intake delayed angiotensin II-induced hypertension in mice with a genetic variant of NADPH oxidase. Am J Hypertens 24: 114-118, 2011.
14. Heumuller S, Wind S, Barbosa-Sicard E, Schmidt HH, Busse R, Schroder K, Brandes RP. Apocynin is not an inhibitor of vascular reduced NADPH oxidases but an antioxidant. Hypertension 51: 211-217, 2008.
15. Infanger DW, Sharma RV, Davisson RL. NADPH oxidase of the brain: distribution, regulation, and function. Antioxid Redox Signal 8: 1583- 1596, 2006.
16. Iwashima F, Yoshimoto T, Minami I, Sakurada M, Hirono Y, Hirata Y. Aldosterone induces superoxide generation via Rac1 activation in endothelial cells. Endocrinology 149: 1009-1014, 2008.
17. Johar S, Cave AC, Narayanapanicker A, Grieve DJ, Shah AM. Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase. FASEB J 20: 1546-1548, 2006.
18. Koga Y, Hirooka Y, Araki S, Nozoe M, Kishi T, Sunagawa K. High salt intake enhances blood pressure increase during development of hypertension via oxidative stress in rostral ventrolateral medulla of spontaneously hypertensive rats. Hypertens Res 31: 2075-2083, 2008.
19. Kopkan L, Hess A, Husková Z, Cervenka L, Navar LG, Majid DS. High-salt intake enhances superoxide activity in eNOS knockout mice leading to the development of salt sensitivity. Am J Physiol Renal Physiol 299: F656-F6563, 2010.
20. Lambeth JD. NOX enzymes and the biology of reactive oxygen. Nat Rev Immunol 4: 181-189, 2004.
21. Nagae A, Fujita M, Kawarazaki H, Matsui H, Ando K, Fujita T. Sympathoexcitation by oxidative stress in the brain mediates arterial pressure elevation in obesity-induced hypertension. Circulation 119: 978- 986, 2009.
22. Nishiyama A, Yao L, Nagai Y, Miyata K, Yoshizumi M, Kagami S, Kondo S, Kiyomoto H, Shokoji T, Kimura S, Kohno M, Abe Y. Possible contributions of reactive oxygen species and mitogen-activated protein kinase to renal injury in aldosterone/salt-induced hypertensive rats. Hypertension 43: 841-848, 2004.
23. Oliveira-Sales EB, Nishi EE, Carillo BA, Boim MA, Dolnikoff MS, Bergamaschi CT, Campos RR. Oxidative stress in the sympathetic premotor neurons contributes to sympathetic activation in renovascular hypertension. Am J Hypertens 22: 484-492, 2009.
24. Peterson JR, Burmeister MA, Tian X, Zhou Y, Guruju MR, Stupinski JA, Sharma RV, Davisson RL. Genetic silencing of Nox2 and Nox4 reveals differential roles of these NADPH oxidase homologues in the vasopressor and dipsogenic effects of brain angiotensin II. Hypertension 54: 1106-1114, 2009.
25. Peterson JR, Sharma RV, Davisson RL. Reactive oxygen species in the neuropathogenesis of hypertension. Curr Hypertens Rep 8: 232-241, 2006.
26. Pitt B, Zannad F, Remme WJ, Cody R, Castaigne A, Perez A, Palensky J, Wittes J. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 341: 709-717, 1999.
27. Queisser N, Fazeli G, Schupp N. Superoxide anion and hydrogen peroxide-induced signaling and damage in angiotensin II and aldosterone action. Biol Chem 391: 1265-1279, 2010.
28. Somers MJ, Mavromatis K, Galis ZS, Harrison DG. Vascular superoxide production and vasomotor function in hypertension induced by deoxycorticosterone acetate-salt. Circulation 101: 1722-1728, 2000.
29. Stier CT Jr, Rocha R, Chander PN. Effect of aldosterone and MR blockade on the brain and the kidney. Heart Fail Rev 10: 53-62, 2005.
30. Ueyama T, Geiszt M, Leto TL. Involvement of Rac1 in activation of multi-component Nox1 and Nox3-based NADPH oxidases. Mol Cell Biol 26: 2160-2174, 2006.
31. Xue B, Beltz TG, Yu Y, Guo F, Gomez-Sanchez CE, Hay M, Johnson AK. Central interactions of aldosterone and angiotensin II in aldosterone-and angiotensin II-induced hypertension. Am J Physiol Heart Circ Physiol 300: H555-H564, 2011.
32. Ye S, Zhong H, Yanamadala S, Campese VM. Oxidative stress mediates the stimulation of sympathetic nerve activity in the phenol renal injury model of hypertension. Hypertension 48: 309-315, 2006.
33. Yu Y, Wei SG, Zhang ZH, Gomez-Sanchez E, Weiss RM, Felder RB. Does aldosterone upregulate the brain renin-angiotensin system in rats with heart failure? Hypertension 51: 727-733. 2008.
34. Zhang ZH, Kang YM, Yu Y, Wei SG, Schmidt TJ, Johnson AK, Felder RB. 11fj-hydroxysteroid dehydrogenase type 2 activity in hypothalamic paraventricular nucleus modulates sympathetic excitation. Hypertension 48: 127-133, 2006.
35. Zhang ZH, Yu Y, Kang YM, Wei SG, Felder RB. Aldosterone acts centrally to increase brain renin-angiotensin system activity and oxidative stress in normal rats. Am J Physiol Heart Circ Physiol 294: H1067-H1074, 2008.