Vaccinia-based influenza vaccine overcomes previously induced immunodominance hierarchy for heterosubtypic protection

European Journal of Immunology

Volumn 44, Issue 8, 2014, Pages 2360-2369

  Kwon, Ji Sun ^a   Yoon, Jungsoon ^a   Kim, Yeon Jung ^a   Kang, Kyuho ^a,f   Woo, Sunje ^b   Jung, Dea Im ^b   Song, Man Ki ^b   Kim, Eun Ha ^c   Kwon, Hyeok il ^c   Choi, Young Ki ^c   Kim, Jihye ^d   Lee, Jeewon ^d   Yoon, Yeup ^a,g   Shin, Eui Cheol ^d   Youn, Jin Won ^a,e  

^a Mogam Biotechnology Research Institute   (South Korea)

^b International Vaccine Institute   (South Korea)

^c Chungbuk National University College of Medicine   (South Korea)

^d Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^e CJ HealthCare   (South Korea)

^f WEILL CORNELL MEDICAL COLLEGE   (United States)

^g Sungkyunkwan University   (South Korea)

Author keywords

Consensus sequence; Heterosubtypic protection; Immunodominance hierarchy; T cell immunity; Universal influenza vaccine

Indexed keywords

EPITOPE; GAMMA INTERFERON; INFLUENZA VACCINE; UNCLASSIFIED DRUG; VACCINIA VECTOR; VIRUS VECTOR;

2009 H1N1 INFLUENZA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AVIAN INFLUENZA VIRUS; CELLULAR IMMUNITY; CONSENSUS SEQUENCE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOKINE RESPONSE; ENZYME LINKED IMMUNOSPOT ASSAY; FEASIBILITY STUDY; FEMALE; GENE EXPRESSION; HETEROSUBTYPIC PROTECTION; HUMAN; HUMAN CELL; IMMUNOGENICITY; IMMUNOPROPHYLAXIS; INFLUENZA; INFLUENZA A (H1N1); INFLUENZA A (H3N2); INFLUENZA A (H5N1); INFLUENZA VACCINATION; LD 50; LOW DRUG DOSE; LYMPHOCYTE FUNCTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SWINE INFLUENZA VIRUS; T LYMPHOCYTE; VIRAL GENE DELIVERY SYSTEM; VIRUS MUTATION;

CONSENSUS SEQUENCE; HETEROSUBTYPIC PROTECTION; IMMUNODOMINANCE HIERARCHY; T-CELL IMMUNITY; UNIVERSAL INFLUENZA VACCINE;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA VACCINES; INFLUENZA, HUMAN; MICE; MICE, INBRED C57BL; ORTHOMYXOVIRIDAE INFECTIONS; SWINE; T-LYMPHOCYTES; VACCINIA; VACCINIA VIRUS;

EID: 84906082332     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201344005     Document Type: Article

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