The magnitude and specificity of influenza A virus-specific cytotoxic T-lymphocyte responses in humans is related to HLA-A and -B phenotype

Journal of Virology

Volumn 76, Issue 2, 2002, Pages 582-590

  Boon, A C M ^a   De Mutsert, G ^a   Graus, Y M F ^a   Fouchier, R A M ^a   Sintnicolaas, K ^a   Rimmelzwaan, A D M E ^a   Osterhaus, G F ^a  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; HLA A ANTIGEN; HLA A1 ANTIGEN; HLA A2 ANTIGEN; HLA B ANTIGEN; HLA B27 ANTIGEN; HLA B35 ANTIGEN; HLA B8 ANTIGEN;

ALLELISM; ANTIGEN EXPRESSION; ANTIGEN RECOGNITION; ARTICLE; CELL STIMULATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HLA SYSTEM; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFLUENZA VIRUS A; MONONUCLEAR CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

ADULT; ALLELES; ANTIGEN-PRESENTING CELLS; ANTIGENS, VIRAL; CYTOTOXICITY, IMMUNOLOGIC; EPITOPES, T-LYMPHOCYTE; GENOTYPE; HLA-A ANTIGENS; HLA-A2 ANTIGEN; HLA-B ANTIGENS; HUMANS; INFLUENZA A VIRUS; LYMPHOCYTE COUNT; MIDDLE AGED; PHENOTYPE; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0036138764     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.2.582-590.2002     Document Type: Article

References (52)

1. Regulation of antigen-specific CD8(+) T cell homeostasis by perforin and interferongamma
2. The minimum peptide epitope from the influenza virus matrix protein. Extra and intracellular loading of HLA-A2
3. Characteristics of virus-specific CD8(+) T cells in the liver during the control and resolution phases of influenza pneumonia
4. Contemporary analysis of MHC-related immunodominance hierarchies in the CD8+ T cell response to influenza A viruses
5. A previously unrecognized H-2D(b)-restricted peptide prominent in the primary influenza A virus-specific CD8(+) T-cell response is much less apparent following secondary challenge
6. Diversity of epitope and cytokine profiles for primary and secondary influenza A virus-specific CD8+ T cell responses
7. Murine cytotoxic T lymphocyte recognition of individual influenza virus proteins. High frequency of nonresponder MHC class I alleles
8. Immunodominance in T lymphocyte recognition
9. Putative immunodominant human immunodeficiency virus-specific CD8(+) T-cell responses cannot be predicted by major histocompatibility complex class I haplotype
10. Evolution of the T cell repertoire during primary, memory, and recall responses to viral infection
11. Facing two T cell epitopes: A degree of randomness in the primary response is lost upon secondary immunization
12. Determinant selection of major histocompatibility complex class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by nondominant anchor residues
13. Immunoproteasomes shape immunodominance hierarchies of antiviral CD8(+) T cells at the levels of T cell repertoire and presentation of viral antigens
14. Modification of cysteine residues in vitro and in vivo affects the immunogenicity and antigenicity of major histocompatibility complex class I-restricted viral determinants
15. Immunodominance among EBV-derived epitopes restricted by HLA-B27 does not correlate with epitope abundance in EBV-transformed B-lymphoblastoid cell lines
16. Immunodominance of major histocompatibility complex class I-restricted influenza virus epitopes can be influenced by the T-cell receptor repertoire
17. HLA-A1 and HLA-A3 T cell epitopes derived from influenza virus proteins predicted from peptide binding motifs
18. Cytotoxic T-cell responses in mice infected with influenza and vaccinia viruses vary in magnitude with H-2 genotype
19. An HLA-B35-restricted epitope modified at an anchor residue results in an antagonist peptide
20. Control of HIV-1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosity
21. Protective immunity does not correlate with the hierarchy of virus-specific cytotoxic T cell responses to naturally processed peptides
22. A protective cytotoxic T cell response to a subdominant epitope is influenced by the stability of the MHC class I/peptide complex and the overall spectrum of viral peptides generated within infected cells
23. Multiple HLA A11-restricted cytotoxic T-lymphocyte epitopes of different immunogenicities in the Epstein-Barr virus-encoded nuclear antigen 4
24. Human memory CTL response specific for influenza A virus is broad and multispecific
25. Identification of viral molecules recognized by influenza-specific human cytotoxic T lymphocytes
26. Molecular analysis of the association of HLA-B53 and resistance to severe malaria
27. Structural homologies between two HLA B27-restricted peptides suggest residues important for interaction with HLA B27
28. Human cytotoxic T-lymphocyte repertoire to influenza A viruses
29. Human CD8+ and CD4+ T lymphocyte memory to influenza A viruses of swine and avian species
30. The influence of HLA class I alleles and heterozygosity on the outcome of human T cell lymphotropic virus type I infection
31. Rapid effector function in CD8+ memory T cells
32. In vivo effector function of influenza virus-specific cytotoxic T lymphocyte clones is highly specific
33. Definition of a human T cell epitope from influenza A non-structural protein 1 using HLA-A2.1 transgenic mice
34. Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells
35. In vitro human cytotoxic T cell responses against influenza A virus can he induced and selected by synthetic peptides
36. Antibody response to immunization with influenza A/USSR/77 (H1N1) virus in young individuals primed or unprimed for A/New Jersey/76 (H1N1) virus
37. Cytotoxic T-cell immunity to influenza
38. Sequences that flank subdominant and cryptic epitopes influence the proteolytic generation of MHC class I-presented peptides
39. Identification of the nonamer peptide from influenza A matrix protein and the role of pockets of HLA-A2 in its recognition by cytotoxic T lymphocytes
40. High peptide affinity for MHC class I does not correlate with immunodominance
41. Comparison of RNA hybridization, hemagglutination assay, titration of infectious virus and immunofluorescence as methods for monitoring influenza virus replication in vitro
42. A randomized, double blind study in young healthy adults comparing cell mediated and humoral immune responses induced by influenza ISCOM vaccines and conventional vaccines
43. A broad cytotoxic T lymphocyte response to influenza type B virus presented by multiple HLA molecules
44. Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi
45. Development of Epstein-Barr virus-specific memory T cell receptor clonotypes in acute infectious mononucleosis
46. A sequence pattern for peptides presented to cytotoxic T lymphocytes by HLA B8 revealed by analysis of epitopes and eluted peptides
47. Different MHC class I alleles compete for presentation of overlapping viral epitopes
48. Heterologous protection against influenza by injection of DNA encoding a viral protein
49. Analysis of cytotoxic T cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection
50. Antigenic drift in the influenza A virus (H3N2) nucleoprotein and escape from recognition by cytotoxic T lymphocytes
51. Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responses