Structure-based design of NS2 mutants for attenuated influenza A virus vaccines

Virus Research

Volumn 155, Issue 1, 2011, Pages 240-248

  Akarsu, Hatice ^a,b,f   Iwatsuki Horimoto, Kiyoko ^b   Noda, Takeshi ^b   Kawakami, Eiryo ^b   Katsura, Hiroaki ^b   Baudin, Florence ^a,c   Horimoto, Taisuke ^b,g   Kawaoka, Yoshihiro ^b,d,e  

^a UMI 3265 UJF EMBL CNRS   (France)

^b THE UNIVERSITY OF TOKYO   (Japan)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^e UNIVERSITY OF WISCONSIN MADISON   (United States)

^f UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^g UNIVERSITY OF TOKYO   (Japan)

Author keywords

Influenza A virus; NS2 NEP; Polymerase activity; Reverse genetics; Virulence

Indexed keywords

AMINO ACID; GLUTAMIC ACID; INFLUENZA VACCINE; NONSTRUCTURAL PROTEIN 1; NONSTRUCTURAL PROTEIN 2; VIRUS PROTEIN;

ADDITION REACTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG INHIBITION; DRUG STRUCTURE; EMBRYO; FEMALE; GENE MUTATION; GENETICS; HUMAN; HUMAN CELL; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; SUBSTITUTION REACTION; VIROGENESIS; VIRUS ATTENUATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; DISEASE MODELS, ANIMAL; DOGS; FEMALE; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA VACCINES; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; ORTHOMYXOVIRIDAE INFECTIONS; SURVIVAL ANALYSIS; VACCINES, ATTENUATED; VIRAL NONSTRUCTURAL PROTEINS;

ANIMALIA; INFLUENZA A VIRUS; MUS;

EID: 78650544136     PISSN: 01681702     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.virusres.2010.10.014     Document Type: Article

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