-
1
-
-
0036632368
-
The phosphatidylinositol 3-kinase AKT pathway in human cancer
-
Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Can 2002; 2: 489-501
-
(2002)
Nat Rev Can
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
2
-
-
33746257209
-
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
-
Engelman JA, Luo J, Cantley LC. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 2006; 7: 606-619
-
(2006)
Nat Rev Genet
, vol.7
, pp. 606-619
-
-
Engelman, J.A.1
Luo, J.2
Cantley, L.C.3
-
4
-
-
42449165060
-
Contributions of the raf/mek/erk pi3k/pten/akt/mtor and jak/stat pathways to leukemia
-
Steelman LS, Abrams SL, Whelan J, et al. Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia. Leukemia 2008; 22: 686-707
-
(2008)
Leukemia
, vol.22
, pp. 686-707
-
-
Steelman, L.S.1
Abrams, S.L.2
Whelan, J.3
-
5
-
-
42449146501
-
Targeting survival cascades induced by activation of ras/raf/mek/erk pi3k/pten/akt/mtor and jak/stat pathways for effective leukemia therapy
-
McCubrey JA, Steelman LS, Abrams SL, et al. Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy. Leukemia 2008; 22: 708-722
-
(2008)
Leukemia
, vol.22
, pp. 708-722
-
-
McCubrey, J.A.1
Steelman, L.S.2
Abrams, S.L.3
-
6
-
-
31944448780
-
Oncogenic transformation induced by the p110beta-gamma, and-delta isoforms of class i phosphoinositide 3-kinase
-
Kang S, Denley A, Vanhaesebroeck B, Vogt PK. Oncogenic transformation induced by the p110beta,-gamma, and-delta isoforms of class I phosphoinositide 3-kinase. Proc Natl Acad Sci U S A 2006; 103: 1289-1294
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 1289-1294
-
-
Kang, S.1
Denley, A.2
Vanhaesebroeck, B.3
Vogt, P.K.4
-
7
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
Samuels Y, Wang Z, Bardelli A, et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 2004; 304: 554
-
(2004)
Science
, vol.304
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
-
8
-
-
13944284494
-
Oncogenic mutations of PIK3CA in human cancers
-
Samuels Y, Velculescu VE. Oncogenic mutations of PIK3CA in human cancers. Cell Cycle 2004; 3: 1221-1224
-
(2004)
Cell Cycle
, vol.3
, pp. 1221-1224
-
-
Samuels, Y.1
Velculescu, V.E.2
-
9
-
-
84857844598
-
PI3Kd inhibitors in cancer: Rationale and serendipity merge in the clinic
-
Fruman DA, Rommel C. PI3Kd inhibitors in cancer: Rationale and serendipity merge in the clinic. Cancer Discov 2011; 1: 562-572
-
(2011)
Cancer Discov
, vol.1
, pp. 562-572
-
-
Fruman, D.A.1
Rommel, C.2
-
10
-
-
0030612144
-
P110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes
-
Chantry D, Vojtek A, Kashishian A, et al. p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. J Biol Chem 1997; 272: 19236-19241
-
(1997)
J Biol Chem
, vol.272
, pp. 19236-19241
-
-
Chantry, D.1
Vojtek, A.2
Kashishian, A.3
-
11
-
-
0030611198
-
P110delta, a novel phosphoinositide 3-kinase in leukocytes
-
Vanhaesebroeck B, Welham MJ, Kotani K, et al. P110delta, a novel phosphoinositide 3-kinase in leukocytes. Proc Natl Acad Sci U S A 1997; 94: 4330-4335
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 4330-4335
-
-
Vanhaesebroeck, B.1
Welham, M.J.2
Kotani, K.3
-
12
-
-
0035892106
-
Survival of leukemic B cells promoted by engagement of the antigen receptor
-
Bernal A, Pastore RD, Asgary Z, et al. Survival of leukemic B cells promoted by engagement of the antigen receptor. Blood 2001; 98: 3050-3057
-
(2001)
Blood
, vol.98
, pp. 3050-3057
-
-
Bernal, A.1
Pastore, R.D.2
Asgary, Z.3
-
13
-
-
73849145729
-
Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
-
Davis RE, Ngo VN, Lenz G, et al. Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. Nature 2010; 463: 88-92
-
(2010)
Nature
, vol.463
, pp. 88-92
-
-
Davis, R.E.1
Ngo, V.N.2
Lenz, G.3
-
14
-
-
11444259307
-
Microenvironmental interactions and survival of CLL B-cells
-
Munk Pedersen I, Reed J. Microenvironmental interactions and survival of CLL B-cells. Leuk Lymphoma 2004; 45: 2365-2372
-
(2004)
Leuk Lymphoma
, vol.45
, pp. 2365-2372
-
-
Munk Pedersen, I.1
Reed, J.2
-
15
-
-
84887002216
-
The phosphatidylinositol-3-kinase inhibitor NVP-BKM120 overcomes resistance signals derived from microenvironment by regulating the Akt/FoxO3a/Bim axis in chronic lymphocytic leukemia cells
-
Rosich L, Saborit-Villarroya I, Lopez-Guerra M, et al. The phosphatidylinositol-3-kinase inhibitor NVP-BKM120 overcomes resistance signals derived from microenvironment by regulating the Akt/FoxO3a/Bim axis in chronic lymphocytic leukemia cells. Haematologica 2013; 98: 1739-1747
-
(2013)
Haematologica
, vol.98
, pp. 1739-1747
-
-
Rosich, L.1
Saborit-Villarroya, I.2
Lopez-Guerra, M.3
-
16
-
-
84867051939
-
Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics
-
Schmitz R, Young RM, Ceribelli M, et al. Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics. Nature 2012; 490: 116-120
-
(2012)
Nature
, vol.490
, pp. 116-120
-
-
Schmitz, R.1
Young, R.M.2
Ceribelli, M.3
-
17
-
-
76349098519
-
Phosphoinositide 3-kinase p110 delta regulates natural antibody production, marginal zone and B-1 B cell function, and autoantibody responses
-
Durand CA, Hartvigsen K, Fogelstrand L, et al. Phosphoinositide 3-kinase p110 delta regulates natural antibody production, marginal zone and B-1 B cell function, and autoantibody responses. J Immunol 2009; 183: 5673-5684
-
(2009)
J Immunol
, vol.183
, pp. 5673-5684
-
-
Durand, C.A.1
Hartvigsen, K.2
Fogelstrand, L.3
-
18
-
-
0037695593
-
Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex
-
Jou ST, Carpino N, Takahashi Y, et al. Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex. Mol Cell Biol 2002; 22: 8580-8591
-
(2002)
Mol Cell Biol
, vol.22
, pp. 8580-8591
-
-
Jou, S.T.1
Carpino, N.2
Takahashi, Y.3
-
19
-
-
0037047590
-
Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice
-
Okkenhaug K, Bilancio A, Farjot G, et al. Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice. Science 2002; 297: 1031-1034
-
(2002)
Science
, vol.297
, pp. 1031-1034
-
-
Okkenhaug, K.1
Bilancio, A.2
Farjot, G.3
-
20
-
-
51849098272
-
Drug discovery approaches targeting the PI3K/Akt pathway in cancer
-
Garcia-Echeverria C, Sellers WR. Drug discovery approaches targeting the PI3K/Akt pathway in cancer. Oncogene 2008; 27: 5511-5526
-
(2008)
Oncogene
, vol.27
, pp. 5511-5526
-
-
Garcia-Echeverria, C.1
Sellers, W.R.2
-
21
-
-
78751553221
-
CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability
-
Lannutti BJ, Meadows SA, Herman SE, et al. CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability. Blood 2011; 117: 591-594
-
(2011)
Blood
, vol.117
, pp. 591-594
-
-
Lannutti, B.J.1
Meadows, S.A.2
Herman, S.E.3
-
22
-
-
77957201023
-
Phosphatidylinositol 3-kinase-delta inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals
-
Herman SE, Gordon AL, Wagner AJ, et al. Phosphatidylinositol 3-kinase-delta inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals. Blood 2010; 116: 2078-2088
-
(2010)
Blood
, vol.116
, pp. 2078-2088
-
-
Herman, S.E.1
Gordon, A.L.2
Wagner, A.J.3
-
23
-
-
80053345977
-
The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia
-
Hoellenriegel J, Meadows SA, Sivina M, et al. The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia. Blood 2011; 118: 3603-3612
-
(2011)
Blood
, vol.118
, pp. 3603-3612
-
-
Hoellenriegel, J.1
Meadows, S.A.2
Sivina, M.3
-
24
-
-
84901712964
-
Idelalisib, an inhibitor of phosphatidylinositol 3 kinase p110delta, for relapsed/refractory chronic lymphocytic leukemia
-
Brown JR, Byrd JC, Coutre SE, et al. Idelalisib, an inhibitor of phosphatidylinositol 3 kinase p110delta, for relapsed/refractory chronic lymphocytic leukemia. Blood 2014; 123: 3390-3397
-
(2014)
Blood
, vol.123
, pp. 3390-3397
-
-
Brown, J.R.1
Byrd, J.C.2
Coutre, S.E.3
-
25
-
-
84865971916
-
-
San Diego, California, USA: American Society of Hematology in press
-
Sharman J, de Vos S, Leonard J, et al. A phase 1 study of the selective phosphatidylinositol 3-kinase-delta inhibitor, CAL-101 (GS-1101), in combination with rituximab and/or bendamustine in patients with relapsed or refractory chronic lymphocytic leukemia (CLL). San Diego, California, USA: American Society of Hematology; 2011 (in press
-
(2011)
A Phase 1 Study of the Selective Phosphatidylinositol 3-kinase-delta Inhibitor CAL-101 (GS-1101), in Combination with Rituximab And/or Bendamustine in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL
-
-
Sharman, J.1
De Vos, S.2
Leonard, J.3
-
26
-
-
84880202063
-
-
Atlanta, Georgia, USA: American Society of Hematology
-
Coutre S, Leonard J, Furman R, et al. Combinations of the selective phosphatidylinositol 3-kinase-delta (PI3Kdelta) inhibitor GS-1101 (CAL-101) with rituximab and/or bendamustine are tolerable and highly active in patients with relapsed or refractory chronic lymphocytic leukemia (CLL): Results from a phase I study. Atlanta, Georgia, USA: American Society of Hematology; 2012
-
(2012)
Combinations of the Selective Phosphatidylinositol 3-kinase-delta (PI3Kdelta) Inhibitor GS-1101 (CAL-101) with Rituximab And/or Bendamustine Are Tolerable and Highly Active in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL): Results from A Phase i Study
-
-
Coutre, S.1
Leonard, J.2
Furman, R.3
-
28
-
-
84896692766
-
Idelalisib and rituximab in relapsed chronic lymphocytic leukemia
-
Furman RR, Sharman JP, Coutre SE, et al. Idelalisib and rituximab in relapsed chronic lymphocytic leukemia. N Engl J Med 2014; 370: 997-1007
-
(2014)
N Engl J Med
, vol.370
, pp. 997-1007
-
-
Furman, R.R.1
Sharman, J.P.2
Coutre, S.E.3
-
30
-
-
84906083642
-
-
Chicago, Illinois: American Society of Oncology Annual Meeting
-
Flinn I, Kimby E, Cotter FE, et al. A phase III, randomized, controlled study evaluating the efficacy and safety of idelalisib (GS-1101) in combination with ofatumumab for previously treated chronic lymphocytic leukemia (CLL). Chicago, Illinois: American Society of Oncology Annual Meeting; 2013
-
(2013)
A Phase III, Randomized, Controlled Study Evaluating the Efficacy and Safety of Idelalisib (GS-1101 in Combination with Ofatumumab for Previously Treated Chronic Lymphocytic Leukemia (CLL
-
-
Flinn, I.1
Kimby, E.2
Cotter, F.E.3
-
31
-
-
79955977369
-
The role of phosphatidylinositol 3-kinase-delta in the immunomodulatory effects of lenalidomide in chronic lymphocytic leukemia
-
Herman SE, Lapalombella R, Gordon AL, et al. The role of phosphatidylinositol 3-kinase-delta in the immunomodulatory effects of lenalidomide in chronic lymphocytic leukemia. Blood 2011; 117: 4323-4327
-
(2011)
Blood
, vol.117
, pp. 4323-4327
-
-
Herman, S.E.1
Lapalombella, R.2
Gordon, A.L.3
-
32
-
-
84906086804
-
-
Chicago Illinois USA: American Society of Clinical Oncology
-
Coutre S, Byrd J, Furman R, et al. Phase I study of CAL-101, an isoformselective inhibitor of phosphatidylinositol 3-kinase P110d, in patients with previously treated chronic lymphocytic leukemia. Chicago, Illinois, USA: American Society of Clinical Oncology; 2011
-
(2011)
Phase i Study of CAL-101 An Isoformselective Inhibitor of Phosphatidylinositol 3-kinase P110d in Patients with Previously Treated Chronic Lymphocytic Leukemia
-
-
Coutre, S.1
Byrd, J.2
Furman, R.3
-
34
-
-
84906085232
-
-
New Orleans Los Angeles USA: American Society of Hematology
-
Patel M, Kahl BS, Horwitz SM, et al. Preliminary safety and efficacy of IPI-145, a potent inhibitor of phosphoinositide-3-kinase-d, g, in patients with chronic lymphocytic leukemia. New Orleans, Los Angeles, USA: American Society of Hematology; 2013
-
(2013)
Preliminary Safety and Efficacy of IPI-145 A Potent Inhibitor of phosphoinositide-3-kinase-d G in Patients with Chronic Lymphocytic Leukemia
-
-
Patel, M.1
Kahl, B.S.2
Horwitz, S.M.3
-
35
-
-
84901703641
-
Idelalisib, a selective inhibitor of phosphatidylinositol 3-kinase-delta, as therapy for previously treated indolent non-Hodgkin lymphoma
-
Flinn IW, Kahl BS, Leonard JP, et al. Idelalisib, a selective inhibitor of phosphatidylinositol 3-kinase-delta, as therapy for previously treated indolent non-Hodgkin lymphoma. Blood 2014; 123: 3406-3413
-
(2014)
Blood
, vol.123
, pp. 3406-3413
-
-
Flinn, I.W.1
Kahl, B.S.2
Leonard, J.P.3
-
36
-
-
84896693794
-
PI3Kdelta inhibition by idelalisib in patients with relapsed indolent lymphoma
-
Gopal AK, Kahl BS, de Vos S, et al. PI3Kdelta inhibition by idelalisib in patients with relapsed indolent lymphoma. N Engl J Med 2014; 370: 1008-1018
-
(2014)
N Engl J Med
, vol.370
, pp. 1008-1018
-
-
Gopal, A.K.1
Kahl, B.S.2
De Vos, S.3
-
38
-
-
84906081753
-
-
Chicago Illinois USA: American Society of Clinical Oncology
-
Horwitz S, Flinn I, Patel M, et al. Preliminary safety and efficacy of IPI-145, a potent inhibitor of phosphoinositide-3-kinase-d, g, in patients with relapsed/ refractory lymphoma. Chicago, Illinois, USA: American Society of Clinical Oncology; 2013
-
(2013)
Preliminary Safety and Efficacy of IPI-145 A Potent Inhibitor of phosphoinositide-3-kinase-d G in Patients with Relapsed/ Refractory Lymphoma
-
-
Horwitz, S.1
Flinn, I.2
Patel, M.3
-
39
-
-
24944592507
-
Gene expression profiling of mantle cell lymphoma cells reveals aberrant expression of genes from the pi3k-Akt, wnt and tgfbeta signalling pathways
-
Rizzatti EG, Falcao RP, Panepucci RA, et al. Gene expression profiling of mantle cell lymphoma cells reveals aberrant expression of genes from the PI3K-AKT, WNT and TGFbeta signalling pathways. Br J Haematol 2005; 130: 516-526
-
(2005)
Br J Haematol
, vol.130
, pp. 516-526
-
-
Rizzatti, E.G.1
Falcao, R.P.2
Panepucci, R.A.3
-
40
-
-
46749155539
-
Distinct functional significance of Akt and mTORconstitutive activation inmantle cell lymphoma
-
Dal Col J, Zancai P, Terrin L, et al. Distinct functional significance of Akt and mTORconstitutive activation inmantle cell lymphoma. Blood2008;111: 5142-5151
-
(2008)
Blood
, vol.111
, pp. 5142-5151
-
-
Dal Col, J.1
Zancai, P.2
Terrin, L.3
-
41
-
-
84901724050
-
A phase 1 study of the pi3kd inhibitor idelalisib in patients with relapsed/refractory mantle cell lymphoma (mcl
-
Kahl BS, Spurgeon SE, Furman RR, et al. A phase 1 study of the PI3Kd inhibitor idelalisib in patients with relapsed/refractory mantle cell lymphoma (MCL). Blood 2014; 123: 3398-3405
-
(2014)
Blood
, vol.123
, pp. 3398-3405
-
-
Kahl, B.S.1
Spurgeon, S.E.2
Furman, R.R.3
-
42
-
-
84906099263
-
-
Chicago, Illinois, USA: American Society of Clinical Oncology
-
Wagner-Johnston N, De Vos S, Leonard J, et al. Preliminary results of PI3Kd inhibitor idelalisib (GS-1101) treatment in combination with everolimus, bortezomib, or bendamustine/rituximab in patients with previously treated mantle cell lymphoma (MCL). Chicago, Illinois, USA: American Society of Clinical Oncology; 2013
-
(2013)
Preliminary Results of PI3Kd Inhibitor Idelalisib (GS-1101) Treatment in Combination with Everolimus Bortezomib or Bendamustine/rituximab in Patients with Previously Treated Mantle Cell Lymphoma (MCL
-
-
Wagner-Johnston, N.1
De Vos, S.2
Leonard, J.3
-
43
-
-
84863116183
-
PI3Kdelta inhibitor, GS-1101 (CAL-101), attenuates pathway signaling, induces apoptosis, and overcomes signals from the microenvironment in cellular models of Hodgkin lymphoma
-
Meadows SA, Vega F, Kashishian A, et al. PI3Kdelta inhibitor, GS-1101 (CAL-101), attenuates pathway signaling, induces apoptosis, and overcomes signals from the microenvironment in cellular models of Hodgkin lymphoma. Blood 2012; 119: 1897-1900
-
(2012)
Blood
, vol.119
, pp. 1897-1900
-
-
Meadows, S.A.1
Vega, F.2
Kashishian, A.3
-
44
-
-
84906100558
-
-
Lugano, Switzerland
-
Horwitz S, Younes A, Flinn I, et al. Preliminary safety and efficacy of IPI-145, a potent inhibitor of phosphoinositide-3-kinase-delta, gamma, in patients with relapsed/refractory T-cell lymphoma International Conference on Malignant Lymphoma; 2013; Lugano, Switzerland
-
(2013)
Preliminary Safety and Efficacy of IPI-145, A Potent Inhibitor of phosphoinositide-3-kinase-delta, Gamma, in Patients with Relapsed/refractory T-cell Lymphoma International Conference on Malignant Lymphoma
-
-
Horwitz, S.1
Younes, A.2
Flinn, I.3
-
45
-
-
84906098252
-
-
Atlanta Georgia USA: American Society of Hematology
-
Herko A, Mavis M, Czuczman M, Hernandez F. AMG 319, a novel inhibitor of phosphoinositide-3 kinase delta (PI3Kd), demonstrates activity in lymphoma pre-clinical models. Atlanta, Georgia, USA: American Society of Hematology; 2012
-
(2012)
AMG 319 A Novel Inhibitor of phosphoinositide-3 Kinase Delta (PI3Kd) Demonstrates Activity in Lymphoma Pre-clinical Models
-
-
Herko, A.1
Mavis, M.2
Czuczman, M.3
Hernandez, F.4
-
46
-
-
84906094827
-
-
New Orleans Los Angeles USA: American Society of Hematology
-
Savona M, Gutierrez M, Lanasa M, et al. A phase I dose escalation study of TGR-1202, a novel PI3K-d inhibitor, for patients with relapsed or refractory hematologic malignancies. New Orleans, Los Angeles, USA: American Society of Hematology; 2013
-
(2013)
A Phase i Dose Escalation Study of TGR-1202 A Novel PI3K-d Inhibitor for Patients with Relapsed or Refractory Hematologic Malignancies
-
-
Savona, M.1
Gutierrez, M.2
Lanasa, M.3
-
47
-
-
84856826293
-
Identification and characterization of nvp-bkm120, an orally available pan-class i pi3-kinase inhibitor
-
Maira SM, Pecchi S, Huang A, et al. Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor. Mol Cancer Ther 2012; 11: 317-328
-
(2012)
Mol Cancer Ther
, vol.11
, pp. 317-328
-
-
Maira, S.M.1
Pecchi, S.2
Huang, A.3
|