Knock-in model of Dravet syndrome reveals a constitutive and conditional reduction in sodium current

Journal of Neurophysiology

Volumn 112, Issue 4, 2014, Pages 903-912

  Schutte, Ryan J ^a,b   Schutte, Soleil S ^a,b   Algara, Jacqueline ^a   Barragan, Eden V ^a   Gilligan, Jeff ^c   Staber, Cynthia ^c   Savva, Yiannis A ^c   Smith, Martin A ^b   Reenan, Robert ^c   O'Dowd, Diane K ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c BROWN UNIVERSITY   (United States)

Author keywords

Dravet syndrome; Drosophila; SCN1A epilepsy; Sodium channel

Indexed keywords

5 HYDROXYTRYPTOPHAN; SODIUM CHANNEL NAV1.1; 4 AMINOBUTYRIC ACID RECEPTOR; SEROTONIN; SODIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DROSOPHILA; EPILEPSY; EPILEPTIC DISCHARGE; FEBRILE CONVULSION; HIGH TEMPERATURE; HOMOLOGOUS RECOMBINATION; LOSS OF FUNCTION MUTATION; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; ROOM TEMPERATURE; SEIZURE; SEVERE MYOCLONIC EPILEPSY IN INFANCY; SODIUM CURRENT; TEMPERATURE; WHOLE CELL PATCH CLAMP; X CHROMOSOME; ACTION POTENTIAL; ANIMAL; BRAIN; CYTOLOGY; GENETICS; INTERNEURON; METABOLISM; MISSENSE MUTATION; MYOCLONUS EPILEPSY; PATHOPHYSIOLOGY; PHENOTYPE; PHYSIOLOGY;

5-HYDROXYTRYPTOPHAN; ACTION POTENTIALS; ANIMALS; BRAIN; DROSOPHILA; EPILEPSIES, MYOCLONIC; GABAERGIC NEURONS; INTERNEURONS; MUTATION, MISSENSE; NAV1.1 VOLTAGE-GATED SODIUM CHANNEL; PHENOTYPE; SEROTONIN; SODIUM;

EID: 84906074544     PISSN: 00223077     EISSN: 15221598     Source Type: Journal    
DOI: 10.1152/jn.00135.2014     Document Type: Article

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