Cyp2c44 epoxygenase in the collecting duct is essential for the high K+ intake-induced antihypertensive effect

American Journal of Physiology - Renal Physiology

Volumn 307, Issue 4, 2014, Pages

  Wang, Wen Hui ^a   Zhang, Chengbiao ^a   Lin, Dao Hong ^a   Wang, Lijun ^a   Graves, Joan P ^b   Zeldin, Darryl C ^b   Capdevila, Jorge H ^c  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Cytochrome P 450; Epoxyeicosatrienoic acid; Family 2; Hypertension; Polypeptide 44; Renal sodium excretion; Subfamily c

Indexed keywords

AMILORIDE; CYP2C44 EPOXYGENASE; EPITHELIAL SODIUM CHANNEL; POTASSIUM ION; PROTEIN; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; HIGH POTASSIUM INTAKE; KIDNEY COLLECTING TUBULE; KIDNEY PROXIMAL TUBULE; MOUSE; NONHUMAN; PATCH CLAMP TECHNIQUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SALT INTAKE; SODIUM ABSORPTION; SODIUM EXCRETION; SODIUM RESTRICTION; WILD TYPE;

CYTOCHROME P-450, FAMILY 2, SUBFAMILY C, POLYPEPTIDE 44; EPITHELIAL NA+ CHANNEL; EPOXYEICOSATRIENOIC ACID; HYPERTENSION; RENAL SODIUM EXCRETION;

8,11,14-EICOSATRIENOIC ACID; AMILORIDE; ANIMALS; ARACHIDONIC ACID; BLOOD PRESSURE; CYTOCHROME P-450 ENZYME SYSTEM; EPITHELIAL SODIUM CHANNELS; KIDNEY TUBULES, COLLECTING; KIDNEY TUBULES, DISTAL; MICE; MICE, KNOCKOUT; PATCH-CLAMP TECHNIQUES; POTASSIUM; SODIUM; SODIUM CHLORIDE, DIETARY;

EID: 84906054803     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00123.2014     Document Type: Article

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