Cyp2c44 epoxygenase is essential for preventing the renal sodium absorption during increasing dietary potassium intake

Hypertension

Volumn 59, Issue 2, 2012, Pages 339-347

  Sun, Peng ^a   Antoun, Joseph ^b   Lin, Dao Hong ^a   Yue, Peng ^a   Gotlinger, Katherine H ^a   Capdevila, Jorge ^b   Wang, Wen Hui ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

11,12 EET; Arachidonic acid; ENaC; Hypertension; Kidney

Indexed keywords

11,12 EPOXY 5,8,14 ICOSATRIENOIC ACID; AMILORIDE; ARACHIDONIC ACID; CYTOCHROME P450 2C44; EPITHELIAL SODIUM CHANNEL; FATTY ACID DERIVATIVE; MESSENGER RNA; OXYGENASE; SODIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; FATTY ACID METABOLISM; HIGH POTASSIUM INTAKE; HYPERTENSION; KIDNEY TUBULE ABSORPTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SODIUM BLOOD LEVEL; SODIUM CURRENT; SODIUM URINE LEVEL; URINARY EXCRETION; WHOLE CELL;

ABSORPTION; ANIMALS; ARACHIDONIC ACID; BLOOD PRESSURE; CYTOCHROME P-450 ENZYME SYSTEM; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL SODIUM CHANNEL; HYPERTENSION; KIDNEY; MICE; MICE, KNOCKOUT; PATCH-CLAMP TECHNIQUES; POTASSIUM; POTASSIUM, DIETARY; SODIUM;

EID: 84856251792     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.111.178475     Document Type: Article

References (38)

1. Lawton WJ, Fitz AE, Anderson EA, Sinkey CA, Coleman RA. Effect of dietary potassium on blood pressure, renal function, muscle sympathetic nerve activity, and forearm vascular resistance and flow in normotensive and borderline hypertensive humans. Circulation. 1990;81:173-184. (Pubitemid 20031781)
2. Mervaala EM, Himberg JJ, Laakso J, Tuomainen P, Karppanen H. Beneficial effects of a potassium-and magnesium-enriched salt alternative. Hypertension. 1992;19:535-540.
3. Morris RC Jr, Sebastian A, Forman A, Tanaka M, Schmidlin O. Normotensive salt sensitivity: effects of race and dietary potassium. Hypertension. 1999;33:18-23. (Pubitemid 29061836)
4. Jin L, Chao L, Chao J. Potassium supplement upregulates the expression of renal kallikrein and bradykinin B2 receptor in SHR. Am J Physiol Renal Physiol. 1999;276:F476-F484. (Pubitemid 29157541)
5. Nasjletti A, Erman A, Cagen LM, Brooks DP, Crofton JT, Share L, Baer PG. High potassium intake selectively increases urinary PGF2 αexcretion in the rat. Am J Physiol Renal Physiol. 1985;248:F382-F388. (Pubitemid 15142308)
6. Roman RJ. P450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol Rev. 2002;82:131-185. (Pubitemid 34654217)
7. Holla VR, Makita K, Zaphiropoulos PG, Capdevila JH. The kidney cytochrome P450 2C23 arachidonic acid epoxygenase is upregulated during dietary salt loading. J Clin Invest. 1999;104:751-760. (Pubitemid 29536360)
8. Makita K, Takahashi K, Kerara A, Jacobson HR, Falck JR, Capdevila JH. Experimental and/or genetically controlled alterations of the renal microsomal cytochrome P450 epoxygenase induce hypertension in rats fed a high salt diet. J Clin Invest. 1994;94:2414-2420. (Pubitemid 24379616)
9. Elmarakby AA, Quigley JE, Pollock DM, Imig JD. Tumor necrosis factor {alpha} blockade increases renal Cyp2c23 expression and slows the progression of renal damage in salt-sensitive hypertension. Hypertension. 2006;47:557-562. (Pubitemid 43843875)
10. Zhao X, Pollock DM, Inscho EW, Zeldin DC, Imig JD. Decreased renal cytochrome P450 2C enzymes and impaired vasodilation are associated with angiotensin salt-sensitive hypertension. Hypertension. 2003;41:709-714. (Pubitemid 36314579)
11. Ma YH, Schwartzman ML, Roman RJ. Altered renal P-450 metabolism of arachidonic acid in Dahl salt-sensitive rats. Am J Physiol. 1994;267(regulatory 36):R579-R589. (Pubitemid 24262037)
12. Nakagawa K, Holla VR, Wei Y, Wang WH, Gatica A, Wei S, Mei S, Miller CM, Cha DR, Price EJ, Zent R, Pozzi A, Breyer MD, Guan Y, Falck JR, Waterman MR, Capdevila JH. Salt sensitive hypertension is associated with a dysfunctional Cyp4a10 gene and kidney epithelial sodium channel. J Clin Invest. 2006;116:1696-1702.
13. Imaoka S, Wedlund PJ, Ogawa H, Kimura S, Gonzalez FJ, Kim HY. Identification of CYP2C23 expressed in rat kidney as an arachidonic acid epoxygenase. J Pharmacol Exp Ther. 1993;267:1012-1016.
14. *. Am J Hypertens. 2005;18:530-537.
15. Sun P, Lin DH, Yue P, Jiang H, Gotlinger KH, Schwartzman ML, Falck JR, Goli M, Wang WH. High potassium intake enhances the inhibitory effect of 11, 12-EET on ENaC. J Am Soc Nephrol. 2010;21:1667-1677.
16. Babilonia E, Lin D, Zhang Y, Wei Y, Yue P, Wang WH. Role of gp91phox-containing NADPH oxidase in mediating the effect of K restriction on ROMK channels and renal K excretion. J Am Soc Nephrol. 2007;18:2037-2045. (Pubitemid 47041069)
17. Frindt G, Ergonul Z, Palmer LG. Na channel expression and activity in the medullary collecting duct of rat kidney. Am J Physiol Renal Physiol. 2007;292:F1190-F1196. (Pubitemid 46572437)
18. Wei Y, Lin DH, Kemp R, Yaddanapudi GSS, Nasjletti A, Falck JR, Wang WH. Arachidonic acid inhibits epithelial Na channel via cytochrome P450 (CYP) epoxygenase-dependent metabolic pathways. J Gen Physiol. 2004;124:719-727. (Pubitemid 39628138)
19. 2+-dependent bid conductance K channel in the cortical collecting duct. J Am Soc Nephrol. 2009;20:513-523.
20. Ma J, Qu W, Scarborough PE, Tomer KB, Moomaw CR, Maronpot R, Davis LS, Breyer MD, Zeldin DC. Molecular cloning, enzymatic characterization, developmental expression, and cellular localization of a mouse cytochrome P450 highly expressed in kidney. J Biol Chem. 1999;274:17777-17788.
21. Wang MH, Brand-Schieber E, Zand BA, Nguyen X, Falck JR, Balu N, Schwartzman ML. Cytochrome P450-derived arachidonic acid metabolism in the rat kidney: characterization of selective inhibitors. J Pharmacol Exp Ther. 1998;284:966-973. (Pubitemid 28130824)
22. Imig JD, Navar LG, Roman RJ, Reddy KK, Falck JR. Actions of epoxygenase metabolites on the preglomerular vasculature. J Am Soc Nephrol. 1996;7:2364-2370. (Pubitemid 27465940)
23. Imig JD, Falck JR, Inscho EW. Contribution of cytochrome P450 epoxygenase and hydroxylase pathways to afferent arteriolar autoregulatory responsiveness. Br J Pharmacol. 1999;127:1399-1405. (Pubitemid 29358940)
24. Williams JM, Sharma M, Anjaiahh S, Falck JR, Roman RJ. Role of endogenous CYP450 metabolites of arachidonic acid in maintaining the glomerular protein permeability barrier. Am J Physiol Renal Physiol. 2007;293:F501-F505. (Pubitemid 47358120)
25. Sakairi Y, Jacobson JR, Noland TD, Capdevila JH, Falck JR, Breyer MD. 5, 6-EET inhibits ion transport in collecting duct by stimulating endogenous prostaglandin synthesis. Am J Physiol. 1995;268(renal 37):F931-F939.
26. Sun P, Lin DH, Wang T, Babilonia E, Wang ZJ, Jin Y, Kemp R, Nasjletti A, Wang WH. Low Na intake suppresses expression of CYP2C23 and arachidonic acid-induced inhibition of ENaC. Am J Physiol Renal Physiol. 2006;291:1192-1200.
27. Mujais SK, Chekal MA, Jones WJ, Hayslett JP, Katz AI. Modulation of renal sodium-potassium-adenosine triphosphatase by aldosterone. J Clin Invest. 1986;76:170-176.
28. Verrey F, Kraehenbuhl JP, Rossier BC. Aldosterone induces a rapid increase in the rate of Na, K-ATPase gene transcription in cultured kidney cells. Mol Endocrinol. 1989;3:1369-1376. (Pubitemid 19241030)
29. Palmer LG, Frindt G. Regulation of apical membrane Na and K channels in rat renal collecting tubules by aldosterone. Semin Nephrol. 1992;12:37-43.
30. Smith SR, Klotman PE, Svetkey LP. Potassium chloride lowers blood pressure and causes natriuresis in older patients with hypertension. J Am Soc Nephrol. 1992;2:1302-1309.
31. Bauer JH, Gauntner WC. Effect of potassium chloride on plasma renin activity and plasma aldosterone during sodium restriction in normal man. Kidney Int. 1979;15:286-293. (Pubitemid 9256604)
32. Frindt G, Palmer LG. Effects of dietary K on cell-surface expression of renal ion channels and transporters. Am J Physiol Renal Physiol. 2010;299:F890-F897.
33. Brooks DP, Crofton JT, Share L, Nasjletti A. High potassium intake increases the plasma concentration and urinary excretion of vasopressin in the rat. Experientia. 1986;42:1012-1014. (Pubitemid 16030670)
34. Wang W, Schwab A, Giebisch G. Regulation of small-conductance K channel in apical membrane of rat cortical collecting tubule. Am J Physiol. 1990;259:F494-F502. (Pubitemid 20310459)
35. Frindt G, Shah A, Edvinsson J, Palmer LG. Dietary K regulates ROMK channels in connecting tubule and cortical collecting duct of rat kidney. Am J Physiol Renal Physiol. 2009;296:F347-F354.
36. Fang L, Ganuti R, Kim BY, Wade JB, Welling PA. The ARH adaptor protein regulates endocytosis of the ROMK potassium secretory channel in mouse kidney. J Clin Invest. 2009;119:3278-3289.
37. Rieg T, Vallon V, Sausbier M, Sausbier U, Kaissling B, Ruth P, Osswald H. The role of the BK channel in potassium homeostasis and flow-induced renal potassium excretion. Kidney Int. 2007;72:566-573. (Pubitemid 47312793)
38. Zordoky BNM, El-Kadi AOS. Effect of cytochrome P450 polymorphism on arachidonic acid metabolism and their impact on cardiovascular diseases. Pharmacol Ther. 2010;125:446-463.