The kidney cytochrome P-450 2C23 arachidonic acid epoxygenase is upregulated during dietary salt loading

Journal of Clinical Investigation

Volumn 104, Issue 6, 1999, Pages 751-760

  Holla, Vijaykumar R ^a   Makita, Keiko ^a   Zaphiropoulos, Peter G ^b   Capdevila, Jorge H ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; COMPLEMENTARY DNA; CYTOCHROME P450; ICOSATETRAENOIC ACID; MESSENGER RNA; MICROSOME ENZYME; OXYGENASE; POLYADENYLATED RNA; POLYCLONAL ANTIBODY; RECOMBINANT ENZYME; SODIUM ION;

ANIMAL TISSUE; ARACHIDONIC ACID METABOLISM; ARTICLE; CATALYSIS; DIETARY INTAKE; ENZYME ACTIVITY; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPERTENSION; KIDNEY MICROSOME; MALE; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; SALT INTAKE;

EID: 0032725975     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI7013     Document Type: Article

References (45)

1. Capdevila, J.H., et al. 1992. Cytochrome P-450 arachidonic acid epoxygenase: regulatory control of the renal epoxygenase by dietary salt loading. J. Biol. Chem. 267:21720-21726.
2. Karara, A., et al. 1993. Molecular cloning, expression, and enzymatic characterization of the rat kidney cytochrome P-450 arachidonic acid epoxygenase. J. Biol. Chem. 268:13565-13570.
3. Imaoka, S., et al. 1993. Identification of CYP2C23 expressed in rat kidney as an arachidonic acid epoxygenase. J. Pharmacol. Exp. Ther. 267:1012-1016
4. Capdevila, J.H., et al. 1989. Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase. J. Biol. Cbem. 265:10865-10971.
5. Oliw, E.H. 1994. Oxygenation of polyunsaturated fatty acids by cytochrome P450 monooxygenases. Prog. Lipid Res. 33:329-354.
6. McGiff, J.C. 1991. Cytochrome P-450 metabolism of arachidonic acid. Annu. Rev. Pharmacol. Toxicol. 31:339-369.
7. Harder, D.R., Campbell, W.B., and Roman, R.J. 1995. Role of cytochrome P-450 enzymes and metabolites of arachidonic acid in the control of vascular tone. J. Vasc. Res. 32:79-92.
8. Capdevila, J.H., Zeldin, D., Makita, K., Karara, A., and Falck, J.R. 1995. Cytochrome P450 and the metabolism of arachidonic acid and oxygenated eicosanoids. In Cytochrome P450: structure, mechanism, and biochemistry. 2nd edition. P. Ortiz de Montellano, editor. Plenum Press. New York, NY. 443-471.
9. Makita, K., Falck, J.R., and Capdevila, J.H. 1996. Cytochrome P450, the arachidonic acid cascade, and hypertension: new vistas for an old enzyme system. FASEB J. 10:1456-1463.
10. McGiff, J.C., Steinberg, M., and Quilley, J. 1996. Missing links: cytochrome P450 arachidonate products, a new class of lipid mediators. Trends Cardiovasc. Med. 6:4-10.
11. Rahman, M., Wright, J.T., and Douglas, J.G. 1997. The role of the cytochrome P450-dependent metabolites of arachidonic acid in blood pressure regulation and renal function: a review. Am. J. Hypertens. 10:356-365.
12. Catella, F., Lawson, J.A., Fitzgerald, D.J., and Fitzgerald, G.A. 1990. Endogenous biosynthesis of arachidonic acid epoxides in humans: increased formation in pregnancy-induced hypertension. Proc. Natl. Acad. Sci. USA. 87:5893-5897.
13. Makita, K., et al. 1994. Experimental and/or genetically controlled alterations of the renal microsomal cytochrome P450 epoxygenase induce hypertension in rats fed a high salt diet. J. Clin. Invest. 94:2414-2420.
14. Capdevila, J.H., Falck, J.R., Dishman, E., and Karara, A. 1989. Cytochrome P-450 arachidonate oxygenase. Methods Enzymol. 187:385-394.
15. Capdevila, J.H., Dishman, E., Karara, A., and Falck, J.R. 1991. Cytochrome P450 arachidonic acid epoxygenase: stereochemical characterization of epoxyeicosatrienoic acids. Methods Enzymol. 206:441-453.
16. Sambrook, J., Fritsch, E.F., and Maniatis, T. 1989. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press. Plainview, NY. 7.3-7.52.
17. Yoshioka, H., et al. 1987. Structural analysis and specific expression of microsomal cytochrome P-450(M-1) mRNA in male rat livers. J. Biol. Chem. 262:1706-1711.
18. Omura, T., and Sato, R. 1964. The carbon monoxide binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J. Biol. Chem. 239:2370-2378.
19. Zeldin, D.C., DuBois, R.N., Falck, J.R., and Capdevila, J.H. 1995. Molecular cloning, expression, and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform. Arch. Biochem. Biophys. 322:76-86.
20. Yasokochi, Y., and Masters, B.S.S. 1976. Some properties of a detergent-solubilized NADPH-cytochrome c (cytochrome P-450) reductase purified by biospecific affinity chromatography. J. Biol. Chem. 251:5337-5344.
21. Matsudaira, P. 1987. Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. J. Biol. Chem. 262:10035-10038.
22. Gonzalez, F.J. 1988. The molecular biology of cytochrome P450s. Pharmacol. Rev. 40:243-288.
23. Nelson, D.R., et al. 1996. P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics. 6:1-42.
24. Hsu, M.H., Griffin, K.J., Wang, Y., Kemper, B., and Johnson, E.F. 1993. A single amino acid substitution confers progesterone 6 beta-hydroxylase activity to rabbit cytochrome P450 2C3. J. Biol. Chem. 268:6939-6944.
25. Negishi, M., Uno, T., Darden, T.A., Sueyoshi, T., and Pedersen, L.G. 1996. Structural flexibility and functional versatility of mammalian P450 enzymes. FASEB J. 10:683-689.
26. Emi, Y., Chijiwa, C., and Omura, T. 1990. A different cytochrome P450 form is induced in primary cultures of rat hepatocytes. Proc. Natl. Acad. Sci. USA. 87:9746-9750.
27. Waxman, D.J., 1991. Rat hepatic P450IIA and P450IIC subfamily 7 expression using catalytic, immunochemical, and molecular probes. Methods Enzymol. 206:249-267.
28. Legraverend, C., Mode, A., Welss, T., Robinson, I., and Gustafsson, J.A. 1992. Hepatic steroid hydroxylating enzymes are controlled by the sexually dimorphic pattern of growth hormone secretion in normal and dwarf rats. FASEB J. 6:711-718.
29. Song, B.J., Veech, R.L., Park, S.S., Gelboin, H.V., and Gonzalez, F.J. 1989. Induction of rat hepatic N-nitrosodimethylamine demethylase by acetone is due to protein stabilization. J. Biol. Chem. 264:3568-3572.
30. Zaphiropoulos, P.G. 1991. cDNA cloning and regulation of a novel rat cytochrome P450 of the 2C gene subfamily (P450IIC24). Biochem. Biophys. Res. Commun. 180:645-651.
31. Zaphiropoulos, P.G. 1996. Circular RNAs from transcripts of the rat cytochrome P450 2C24 gene: correlation with exon skipping. Proc. Natl. Acad. Sci. USA. 93:6536-6541.
32. Gonzalez, F.J., Kimura, S., Tamura, S., and Gelboin, H.V. 1991. Expression of mammalian cytochrome P450 using baculovirus. Methods Enzymol. 206:93-99.
33. Cook, E.A., et al. 1990. cDNA and deduced amino acid sequence of a novel cytochrome P-450 from female rat liver mRNA with high homology to P-450 IIC family. Nucleic Acids Res. 18:7156-7160.
34. Sandrine, M., Roussel, F., and Cresteil, T. 1993. Age-and tissue-dependent expression of CYP2C23 in the rat. Biochim. Biophys. Acta. 1172:124-130.
35. Laethem, R.M., Balazy, M., Falck, J.R., Laethem, C.L., and Koop, D.R. 1993. Formation of 19(S)-, 19(R)-, and 18(R)-hydroxyeicosatetraenoic acids by alcohol-inducible cytochrome P450 2E1. J. Biol. Chem. 268:12912-12918.
36. Capdevila, J.H., et al. 1996. The highly stereoselective oxidation of polyunsaturated fatty acids by cytochrome P450BM-3. J. Biol. Chem. 271:22663-22671.
37. Laethem, R.M., Halpert, J.R., and Koop, D.R. 1994. Epoxidation of AA as an active site probe of cytochrome P450 2B isoforms. Biochim. Biophys. Acta. 1206:42-48.
38. Rosolowsky, M., and Campbell, W.B. 1996. Synthesis of hydroxyeicosatetraenoic (HETEs) and epoxyeicosatrienoic acids (EETs) by cultured bovine coronary artery endothelial cells. Biochim. Biophys. Acta. 1299:267-277.
39. Hecker, M., Bara, A.T., Bauersachs, J., and Busse, R. 1994. Characrerization of endothelium-derived hyperpolarizing factor as a cytochrome P450-derived arachidonic acid metabolite in mammals. J. Physiol. 481:407-414.
40. Campbell, W.B., Gebremedhin, D., Pratt, P., and Harder, D.R. 1996. Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circ. Res. 78:415-423.
41. + channels in coronary smooth muscle through a guanine nucleotide binding protein. Circ. Res. 80:877-884.
42. Vanhoutte, P.M., and Mombouli, J.V. 1996. Vascular endothelium: vasoactive mediators. Prog. Cardiovasc. Dis. 39:229-238.
43. Karara, A., Dishman, E., Falck, J.R., and Capdevila, J.H. 1991. Endogenous epoxyeicosatrienoyl-phospholipids. A novel class of cellular glycerolipids containing epoxidized arachidonate moieties. J. Biol. Chem. 266:7561-7569.
44. Stec, D.E., Deng, A.Y., Rapp, J.P., and Roman, R.J. 1996. Cytochrome P4504A genotype cosegregates with hypertension in Dahl SS/Jr rats. Hypertension. 27:564-568.
45. Gu, L., et al. 1966. Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1. J. Clin. Invest. 97:777-788.