White blood cell-based detection of asymptomatic scrapie infection by Ex Vivo assays

PLoS ONE

Volumn 9, Issue 8, 2014, Pages

  Halliez, Sophie ^a   Jaumain, Emilie ^a   Huor, Alvina ^b   Douet, Jean Yves ^b   Lugan, Séverine ^b   Cassard, Hervé ^b   Lacroux, Caroline ^b   Beŕingue, Vincent ^a   Andreóletti, Olivier ^b   Vilette, Didier ^b  

^a CEMAGREF   (France)

^b IHAP   (France)

Author keywords

[No Author keywords available]

Indexed keywords

PRION; PRION PROTEIN;

ANIMAL; ASYMPTOMATIC INFECTION; BIOASSAY; CEREBELLUM; CHEMISTRY; LEUKOCYTE; METABOLISM; MOUSE; PATHOGENICITY; PRION; PROCEDURES; SCRAPIE; SHEEP; TRANSGENIC MOUSE;

ANIMALS; ASYMPTOMATIC INFECTIONS; BIOLOGICAL ASSAY; CEREBELLUM; LEUKOCYTES; MICE; MICE, TRANSGENIC; PRIONS; PRPSC PROTEINS; SCRAPIE; SHEEP;

EID: 84905988625     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0104287     Document Type: Article

References (41)

1. Bruce ME, Will RG, Ironside JW, McConnell I, Drummond D, et al. (1997) Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent. Nature 389: 498-501. (Pubitemid 27435325)
2. Beringue V, Herzog L, Jaumain E, Reine F, Sibille P, et al. (2012) Facilitated cross-species transmission of prions in extraneural tissue. Science 335: 472-475.
3. Bishop MT, Diack AB, Ritchie DL, Ironside JW, Will RG, et al. (2013) Prion infectivity in the spleen of a PRNP heterozygous individual with subclinical variant Creutzfeldt-Jakob disease. Brain 136: 1139-1145.
4. Gill ON, Spencer Y, Richard-Loendt A, Kelly C, Dabaghian R, et al. (2013) Prevalent abnormal prion protein in human appendixes after bovine spongiform encephalopathy epizootic: large scale survey. BMJ 347: f5675.
5. Brown P, Cervenakova L, McShane LM, Barber P, Rubenstein R, et al. (1999) Further studies of blood infectivity in an experimental model of transmissible spongiform encephalopathy, with an explanation of why blood components do not transmit Creutzfeldt-Jakob disease in humans. Transfusion 39: 1169-1178.
6. Brown P, Rohwer RG, Dunstan BC, MacAuley C, Gajdusek DC, et al. (1998) The distribution of infectivity in blood components and plasma derivatives in experimental models of transmissible spongiform encephalopathy. Transfusion 38: 810-816. (Pubitemid 28421640)
7. Mathiason CK, Powers JG, Dahmes SJ, Osborn DA, Miller KV, et al. (2006) Infectious prions in the saliva and blood of deer with chronic wasting disease. Science 314: 133-136. (Pubitemid 44547758)
8. Houston F, Foster JD, Chong A, Hunter N, Bostock CJ (2000) Transmission of BSE by blood transfusion in sheep. Lancet 356: 999-1000.
9. Dassanayake RP, Schneider DA, Herrmann-Hoesing LM, Truscott TC, Davis WC, et al. (2012) Cell-surface expression of PrPC and the presence of scrapie prions in the blood of goats. J Gen Virol 93: 1127-1131.
10. Bons N, Lehmann S, Mestre-Frances N, Dormont D, Brown P (2002) Brain and buffy coat transmission of bovine spongiform encephalopathy to the primate Microcebus murinus. Transfusion 42: 513-516.
11. Llewelyn CA, Hewitt PE, Knight RS, Amar K, Cousens S, et al. (2004) Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusion. Lancet 363: 417-421. (Pubitemid 38210057)
12. Peden AH, Head MW, Ritchie DL, Bell JE, Ironside JW (2004) Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patient. Lancet 364: 527-529. (Pubitemid 39070413)
13. Wroe SJ, Pal S, Siddique D, Hyare H, Macfarlane R, et al. (2006) Clinical presentation and pre-mortem diagnosis of variant Creutzfeldt-Jakob disease associated with blood transfusion: a case report. Lancet 368: 2061-2067. (Pubitemid 44855106)
14. Douet JY, Zafar S, Perret-Liaudet A, Lacroux C, Lugan S, et al. (2014) Detection of infectivity in blood of persons with variant and sporadic Creutzfeldt-Jakob disease. Emerg Infect Dis 20: 114-117.
15. Andreoletti O, Litaise C, Simmons H, Corbiere F, Lugan S, et al. (2012) Highly efficient prion transmission by blood transfusion. PLoS Pathog 8: e1002782.
16. Mathiason CK, Hayes-Klug J, Hays SA, Powers J, Osborn DA, et al. (2010) B cells and platelets harbor prion infectivity in the blood of deer infected with chronic wasting disease. J Virol 84: 5097-5107.
17. Houston F, McCutcheon S, Goldmann W, Chong A, Foster J, et al. (2008) Prion diseases are efficiently transmitted by blood transfusion in sheep. Blood 112: 4739-4745.
18. Cervenakova L, Yakovleva O, McKenzie C, Kolchinsky S, McShane L, et al. (2003) Similar levels of infectivity in the blood of mice infected with human-derived vCJD and GSS strains of transmissible spongiform encephalopathy. Transfusion 43: 1687-1694. (Pubitemid 37518076)
19. Lacroux C, Vilette D, Fernandez-Borges N, Litaise C, Lugan S, et al. (2012) Prionemia and leukocyte-platelet-associated infectivity in sheep transmissible spongiform encephalopathy models. J Virol 86: 2056-2066.
20. McCutcheon S, Alejo Blanco AR, Houston EF, de Wolf C, Tan BC, et al. (2011) All clinically-relevant blood components transmit prion disease following a single blood transfusion: a sheep model of vCJD. PLoS One 6: e23169.
21. Holada K, Vostal JG, Theisen PW, MacAuley C, Gregori L, et al. (2002) Scrapie infectivity in hamster blood is not associated with platelets. J Virol 76: 4649-4650. (Pubitemid 34309601)
22. Castilla J, Saa P, Hetz C, Soto C (2005) In vitro generation of infectious scrapie prions. Cell 121: 195-206. (Pubitemid 40546388)
23. Atarashi R, Wilham JM, Christensen L, Hughson AG, Moore RA, et al. (2008) Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking. Nat Methods 5: 211-212. (Pubitemid 351325633)
24. Tattum MH, Jones S, Pal S, Collinge J, Jackson GS (2010) Discrimination between prion-infected and normal blood samples by protein misfolding cyclic amplification. Transfusion 50: 996-1002.
25. Rubenstein R, Chang B, Gray P, Piltch M, Bulgin MS, et al. (2010) A novel method for preclinical detection of PrPSc in blood. J Gen Virol 91: 1883-1892.
26. Orru CD, Wilham JM, Raymond LD, Kuhn F, Schroeder B, et al. (2011) Prion disease blood test using immunoprecipitation and improved quaking-induced conversion. MBio 2: e00078-00011.
27. Segarra C, Bougard D, Moudjou M, Laude H, Beringue V, et al. (2013) Plasminogen-based capture combined with amplification technology for the detection of PrP(TSE) in the pre-clinical phase of infection. PLoS One 8: e69632.
28. Edgeworth JA, Farmer M, Sicilia A, Tavares P, Beck J, et al. (2011) Detection of prion infection in variant Creutzfeldt-Jakob disease: a blood-based assay. Lancet 377: 487-493.
29. Hunter N, Foster J, Chong A, McCutcheon S, Parnham D, et al. (2002) Transmission of prion diseases by blood transfusion. J Gen Virol 83: 2897-2905. (Pubitemid 35276989)
30. Falsig J, Aguzzi A (2008) The prion organotypic slice culture assay-POSCA. Nat Protoc 3: 555-562. (Pubitemid 351516751)
31. Arellano-Anaya ZE, Savistchenko J, Mathey J, Huor A, Lacroux C, et al. (2011) A simple, versatile and sensitive cell-based assay for prions from various species. PLoS One 6: e20563.
32. Klohn PC, Stoltze L, Flechsig E, Enari M, Weissmann C (2003) A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions. Proc Natl Acad Sci U S A 100: 11666-11671. (Pubitemid 37205992)
33. Le Dur A, Beringue V, Andreoletti O, Reine F, Lai TL, et al. (2005) A newly identified type of scrapie agent can naturally infect sheep with resistant PrP genotypes. Proc Natl Acad Sci U S A 102: 16031-16036. (Pubitemid 41552862)
34. Feraudet C, Morel N, Simon S, Volland H, Frobert Y, et al. (2005) Screening of 145 anti-PrP monoclonal antibodies for their capacity to inhibit PrPSc replication in infected cells. J Biol Chem 280: 11247-11258. (Pubitemid 40418431)
35. Andreoletti O, Orge L, Benestad SL, Beringue V, Litaise C, et al. (2011) Atypical/Nor98 scrapie infectivity in sheep peripheral tissues. PLoS Pathog 7: e1001285.
36. Johnson CJ, Aiken JM, McKenzie D, Samuel MD, Pedersen JA (2012) Highly efficient amplification of chronic wasting disease agent by protein misfolding cyclic amplification with beads (PMCAb). PLoS One 7: e35383.
37. Makarava N, Savtchenko R, Alexeeva I, Rohwer RG, Baskakov IV (2012) Fast and ultrasensitive method for quantitating prion infectivity titre. Nat Commun 3: 741.
38. Wilham JM, Orru CD, Bessen RA, Atarashi R, Sano K, et al. (2010) Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays. PLoS Pathog 6: e1001217.
39. Moudjou M, Sibille P, Fichet G, Reine F, Chapuis J, et al. (2013) Highly infectious prions generated by a single round of microplate-based protein misfolding cyclic amplification. MBio 5: e00829-00813.
40. Kanu N, Imokawa Y, Drechsel DN, Williamson RA, Birkett CR, et al. (2002) Transfer of scrapie prion infectivity by cell contact in culture. Curr Biol 12: 523-530. (Pubitemid 34271365)
41. Paquet S, Langevin C, Chapuis J, Jackson GS, Laude H, et al. (2007) Efficient dissemination of prions through preferential transmission to nearby cells. J Gen Virol 88: 706-713. (Pubitemid 46210911)