All clinically-relevant blood components transmit prion disease following a single blood transfusion: A sheep model of vCJD

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  McCutcheon, Sandra ^a   Blanco, Anthony Richard Alejo ^a   Houston, E Fiona ^b   de Wolf, Christopher ^a   Tan, Boon Chin ^a   Smith, Antony ^c   Groschup, Martin H ^d   Hunter, Nora ^a   Hornsey, Valerie S ^e   MacGregor, Ian R ^e   Prowse, Christopher V ^e   Turner, Marc ^f   Manson, Jean C ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

^d FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

^e SCOTTISH NATIONAL BLOOD TRANSFUSION SERVICE   (United Kingdom)

^f UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BUFFY COAT; BLOOD COMPONENT; BLOOD DONOR; BLOOD SAMPLING; BLOOD TRANSFUSION; CONTROLLED STUDY; CREUTZFELDT JAKOB DISEASE; DISEASE TRANSMISSION; ERYTHROCYTE CONCENTRATE; INCUBATION TIME; LEUKOCYTE COUNT; NONHUMAN; PLASMA; PRION DISEASE; RISK FACTOR; SHEEP; THROMBOCYTE COUNT; ANIMAL; ANIMAL DISEASE; BLOOD; BLOOD COMPONENT THERAPY; BOVINE SPONGIFORM ENCEPHALOPATHY; BRAIN; CATTLE; DISEASE MODEL; ERYTHROCYTE TRANSFUSION; HUMAN; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LEUKAPHERESIS; METABOLISM; PATHOLOGY; THROMBOCYTE TRANSFUSION;

ANIMALIA; OVIS ARIES;

PRION PROTEIN;

ANIMALS; BLOOD COMPONENT TRANSFUSION; BLOOD DONORS; BRAIN; CATTLE; CREUTZFELDT-JAKOB SYNDROME; DISEASE MODELS, ANIMAL; ENCEPHALOPATHY, BOVINE SPONGIFORM; ERYTHROCYTE TRANSFUSION; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LEUKOCYTE REDUCTION PROCEDURES; PLATELET TRANSFUSION; PRION DISEASES; PRPSC PROTEINS; SHEEP;

EID: 80051712984     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0023169     Document Type: Article

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