Infectious prions in the saliva and blood of deer with chronic wasting disease

Science

Volumn 314, Issue 5796, 2006, Pages 133-136

  Mathiason, Candace K ^a   Powers, Jenny G ^b   Dahmes, Sallie J ^c   Osborn, David A ^d   Miller, Karl V ^d   Warren, Robert J ^d   Mason, Gary L ^a   Hays, Sheila A ^a   Hayes Klug, Jeanette ^a   Seelig, Davis M ^a   Wild, Margaret A ^b   Wolfe, Lisa L ^e   Spraker, Terry R ^a   Miller, Michael W ^e   Sigurdson, Christina J ^a   Telling, Glenn C ^f   Hoover, Edward A ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b NATIONAL PARK SERVICE   (United States)

^c Wildlife Artist Supply Company (WASCO) Inc   (United States)

^d UNIVERSITY OF GEORGIA   (United States)

^e NATIONAL WILDLIFE RESEARCH CENTER   (United States)

^f UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHRONIC WASTING DISEASE (CWD); FACILE TRANSMISSION; INFECTIONS; PRIONS;

BIODIVERSITY; BLOOD; DISEASES; GENETIC ENGINEERING;

PROTEINS;

PRION PROTEIN;

BLOOD; DEER; DISEASE TRANSMISSION; FECES; INFECTIOUS DISEASE; PRION DISEASE; SALIVA; URINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOASSAY; BLOOD TRANSFUSION; BODY FLUID; BRAIN; CHRONIC WASTING DISEASE; CONTROLLED STUDY; DEER; DISEASE TRANSMISSION; FECES LEVEL; NONHUMAN; PALATINE TONSIL; PHARYNX; PRION DISEASE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN URINE LEVEL; SALIVA LEVEL;

ANIMALS; BRAIN CHEMISTRY; COHORT STUDIES; DEER; FECES; LYMPHOID TISSUE; PRIONS; SALIVA; WASTING DISEASE, CHRONIC;

CERVIDAE;

EID: 33749618609     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1132661     Document Type: Article

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27. We thank J. Grassi for his gift of PrP monoclonal antibody; M. Perrott for his technical expertise with the NaPTA methodology; K. O'Rourke and L. Hamburg for performing the PRNP genotype analysis; and C. Tedford for his expertise in deer behavior, facility design, and transport. We thank the office of the CSU Vice President for Research (A. Frank and K. Delehoy) for their support in establishing the CWD deer isolation facility. Animals were housed and cared for in accordance to CSU Animal Care and Use Committee regulations. This work was supported by the NIH, National Institute of Allergy and Infectious Diseases, contract N01-AI-25491.