Mechanistic study of Uba5 enzyme and the Ufm1 conjugation pathway

Journal of Biological Chemistry

Volumn 289, Issue 33, 2014, Pages 22648-22658

  Gavin, James M ^a   Hoar, Kara ^a,b   Xu, Qing ^a   Ma, Jingya ^a   Lin, Yafang ^a   Chen, Jiejin ^a   Chen, Wei ^a   Bruzzese, Frank J ^a   Harrison, Sean ^a   Mallender, William D ^a   Bump, Nancy J ^a   Sintchak, Michael D ^a   Bence, Neil F ^a   Li, Ping ^a   Dick, Lawrence R ^a   Gould, Alexandra E ^a   Chen, Jesse J ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b MODERNA THERAPEUTICS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; CHEMICAL ACTIVATION; DECELERATION; ENZYMES;

ACTIVATION MECHANISMS; ENDOPLASMIC RETICULUM STRESS RESPONSE; FEATURE CONTRASTS; MECHANISTIC STUDIES; SUBSTRATE BINDING; THREE-STEP MECHANISM; TWO-STEP MECHANISMS; UBIQUITIN-LIKE PROTEINS;

PROTEINS;

ADENOSINE PHOSPHATE; ADENYLATE CYCLASE; SUMO 2 PROTEIN; UBA5 PROTEIN; UBIQUITIN; UBIQUITIN CONJUGATING ENZYME; UBIQUITIN FOLD MODIFIER 1; UBIQUITIN LIKE PROTEIN; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE; MULTIPROTEIN COMPLEX; PROTEIN; PROTEIN BINDING; UBA5 PROTEIN, HUMAN; UBIQUITIN PROTEIN LIGASE; UFC1 PROTEIN, HUMAN; UFM1 PROTEIN, HUMAN;

ADENYLATION; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME METABOLISM; ENZYME RELEASE; ENZYME SUBSTRATE COMPLEX; HUMAN; IMMUNOPRECIPITATION; KINETICS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN STABILITY; THIN LAYER CHROMATOGRAPHY; WESTERN BLOTTING; CELL LINE; CHEMICAL MODEL; CHEMISTRY; GENETICS; METABOLISM; PROTEIN QUATERNARY STRUCTURE;

ADENOSINE TRIPHOSPHATE; CATALYTIC DOMAIN; CELL LINE; ENZYME ACTIVATION; HUMANS; MODELS, CHEMICAL; MULTIPROTEIN COMPLEXES; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEINS; UBIQUITIN-ACTIVATING ENZYMES; UBIQUITIN-CONJUGATING ENZYMES;

EID: 84905985826     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.573972     Document Type: Article

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