Mechanistic studies of substrate-assisted inhibition of ubiquitin-activating enzyme by adenosine sulfamate analogues

Journal of Biological Chemistry

Volumn 286, Issue 47, 2011, Pages 40867-40877

  Chen, Jesse J ^a   Tsu, Christopher A ^a   Gavin, James M ^a   Milhollen, Michael A ^a   Bruzzese, Frank J ^a   Mallender, William D ^a   Sintchak, Michael D ^a   Bump, Nancy J ^a   Yang, Xiaofeng ^a   Ma, Jingya ^a   Loke, Huay Keng ^a   Xu, Qing ^a   Li, Ping ^a   Bence, Neil F ^a   Brownell, James E ^a   Dick, Lawrence R ^a  

^a MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION PROCESS; ACTIVE SITE; ADDUCT FORMATION; ADENYLATE; BIOLOGICAL PATHWAYS; COMPOUND I; DOSE-DEPENDENT MANNER; MECHANISTIC STUDIES; NUCLEOPHILIC ATTACK; SULFAMATES; THIOESTERS; UBIQUITIN; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITIN-LIKE PROTEINS;

CHEMICAL ACTIVATION; MECHANICS; PROTEINS; PURIFICATION; SUBSTRATES;

ENZYME INHIBITION;

5' O SULFAMOYL N6 [2,3 DIHYDRO 1H INDEN 1 YL]ADENOSINE; ADENOSINE TRIPHOSPHATE; MLN 4924; NUCLEOPHILE; PYROPHOSPHATE; THIOESTER; UBIQUITIN; UBIQUITIN CONJUGATING ENZYME E1; UBIQUITIN CONJUGATING ENZYME E2; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BIOTRANSFORMATION; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSOCIATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROLYSIS; PRIORITY JOURNAL; TRANSTHIOLATION; UBIQUITINATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CATTLE; DIPHOSPHATES; ENZYME INHIBITORS; HUMANS; HYDROLYSIS; KINETICS; SULFHYDRYL COMPOUNDS; SULFONIC ACIDS; UBIQUITIN-ACTIVATING ENZYMES;

EID: 81755189064     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.279984     Document Type: Article

References (32)

1. Balch, W. E., Morimoto, R. I., Dillin, A., and Kelly, J. W. (2008) Science 319, 916-919
2. Cohen, F. E., and Kelly, J. W. (2003) Nature 426, 905-909
3. Mu, T. W., Ong, D. S., Wang, Y. J., Balch, W. E., Yates, J. R., 3rd, Segatori, L., and Kelly, J. W. (2008) Cell 134, 769-781
4. Kane, R. C., Bross, P. F., Farrell, A. T., and Pazdur, R. (2003) Oncologist 8, 508-513
5. Kane, R. C., Dagher, R., Farrell, A., Ko, C. W., Sridhara, R., Justice, R., and Pazdur, R. (2007) Clin. Cancer Res. 13, 5291-5294
6. Nalepa, G., Rolfe, M., and Harper, J. W. (2006) Nat. Rev. Drug Discov. 5, 596-613
7. Hoeller, D., Hecker, C. M., and Dikic, I. (2006) Nat. Rev. Cancer 6, 776-788
8. Hoeller, D., and Dikic, I. (2009) Nature 458, 438-444
9. Bedford, L., Lowe, J., Dick, L. R., Mayer, R. J., and Brownell, J. E. (2011) Nat. Rev. Drug Discov. 10, 29-46
10. Schulman, B. A., and Harper, J. W. (2009) Nat. Rev. Mol. Cell Biol. 10, 319-331
11. Haas, A. L., and Rose, I. A. (1982) J. Biol. Chem. 257, 10329-10337
12. Haas, A. L., Warms, J. V., Hershko, A., and Rose, I. A. (1982) J. Biol. Chem. 257, 2543-2548
13. Pickart, C. M., Kasperek, E. M., Beal, R., and Kim, A. (1994) J. Biol. Chem. 269, 7115-7123
14. Streich, F. C., Jr., and Haas, A. L. (2010) Subcell. Biochem. 54, 1-16
15. Liakopoulos, D., Doenges, G., Matuschewski, K., and Jentsch, S. (1998) EMBO J. 17, 2208-2214
16. Osaka, F., Kawasaki, H., Aida, N., Saeki, M., Chiba, T., Kawashima, S., Tanaka, K., and Kato, S. (1998) Genes Dev. 12, 2263-2268
17. Bohnsack, R. N., and Haas, A. L. (2003) J. Biol. Chem. 278, 26823-26830
18. Soucy, T. A., Smith, P. G., Milhollen, M. A., Berger, A. J., Gavin, J. M., Adhikari, S., Brownell, J. E., Burke, K. E., Cardin, D. P., Critchley, S., Cullis, C. A., Doucette, A., Garnsey, J. J., Gaulin, J. L., Gershman, R. E., Lublinsky, A. R., McDonald, A., Mizutani, H., Narayanan, U., Olhava, E. J., Peluso, S., Rezaei, M., Sintchak, M. D., Talreja, T., Thomas, M. P., Traore, T., Vyskocil, S., Weatherhead, G. S., Yu, J., Zhang, J., Dick, L. R., Claiborne, C. F., Rolfe, M., Bolen, J. B., and Langston, S. P. (2009) Nature 458, 732-736
19. Soucy, T. A., Smith, P. G., and Rolfe, M. (2009) Clin. Cancer Res. 15, 3912-3916
20. Milhollen, M. A., Traore, T., Adams-Duffy, J., Thomas, M. P., Berger, A. J., Dang, L., Dick, L. R., Garnsey, J. J., Koenig, E., Langston, S. P., Manfredi, M., Narayanan, U., Rolfe, M., Staudt, L. M., Soucy, T. A., Yu, J., Zhang, J., Bolen, J. B., and Smith, P. G. (2010) Blood 116, 1515-1523
21. Brownell, J. E., Sintchak, M. D., Gavin, J. M., Liao, H., Bruzzese, F. J., Bump, N. J., Soucy, T. A., Milhollen, M. A., Yang, X., Burkhardt, A. L., Ma, J., Loke, H. K., Lingaraj, T., Wu, D., Hamman, K. B., Spelman, J. J., Cullis, C. A., Langston, S. P., Vyskocil, S., Sells, T. B., Mallender, W. D., Visiers, I., Li, P., Claiborne, C. F., Rolfe, M., Bolen, J. B., and Dick, L. R. (2010) Mol. Cell 37, 102-111
22. Bruzzese, F. J., Tsu, C. A., Ma, J., Loke, H. K., Wu, D., Li, Z., Tayber, O., and Dick, L. R. (2009) Anal. Biochem. 394, 24-29
23. Morrison, J. F., and Walsh, C. T. (1988) Adv. Enzymol. Relat. Areas Mol. Biol. 61, 201-301
24. Valero, E., Varón, R., and García-Carmona, F. (2000) Biochem. J. 350, 237-243
25. Burch, T. J., and Haas, A. L. (1994) Biochemistry 33, 7300-7308
26. Lee, I., and Schindelin, H. (2008) Cell 134, 268-278
27. Lois, L. M., and Lima, C. D. (2005) EMBO J. 24, 439-451
28. Walden, H., Podgorski, M. S., Huang, D. T., Miller, D. W., Howard, R. J., Minor, D. L., Jr., Holton, J. M., and Schulman, B. A. (2003) Mol. Cell 12, 1427-1437
29. Walden, H., Podgorski, M. S., and Schulman, B. A. (2003) Nature 422, 330-334
30. Olsen, S. K., Capili, A. D., Lu, X., Tan, D. S., and Lima, C. D. (2010) Nature 463, 906-912
31. Tokgöz, Z., Bohnsack, R. N., and Haas, A. L. (2006) J. Biol. Chem. 281, 14729-14737
32. Bacik, J. P., Walker, J. R., Ali, M., Schimmer, A. D., and Dhe-Paganon, S. (2010) J. Biol. Chem. 285, 20273-20280